[Analysis of a series pheochromocytoma cases over 15 years]. / Serie de feocromocitomas durante 15 años en Navarra.

BACKGROUND: The pheochromocytoma is a catecholamine secreting tumour derived from chromaffin cells of the sympathetic nervous system. Eighty to eighty-five percent of these tumours are localized in the adrenal medulla. When pheocromocytomas are found outside the adrenal gland they are referred to as extra-adrenal pheochromocytomas or paragangliomas. The diagnosis is confirmed by elevation of catecholamines and the metanephrines in blood plasma and urine. Localization of the tumour should be done following biochemical diagnosis by means of CT scan and/or MRI. The treatment of choice is tumour resection by laparoscopic surgery. MATERIAL AND METHODS: A review was made of all patient medical histories diagnosed with pheochromocytoma confirmed by the pathology reports of Pathological anatomy of the Navarre hospital Complex (Anatomía patológica del Complejo hospitalario de Navarra A y B) between 1996 to 2010. Descriptive analysis was made using the IBM SPSS statistics program. RESULTS: Our series consists of 43 patients diagnosed with pheochromocytoma over a span of 15 years. The average age on presentation was 47 years. Among the younger patients specific genetic syndromes were found. Computerized tomography was the most widely used method of localization. Contradictory results were found regarding perioperative medical management protocols. All pheocromocytoma tumours in this series were benign. CONCLUSIONS: It is advisable to carry out a genetic study on patients under twenty. The biochemical indicators with the greatest diagnostic sensitivity were the levels of normetanephrine and metanephrine in urine. Surgery was the only treatment option.

Serie de feocromocitomas durante 15 años en Navarra / Analysis of a series pheochromocytoma cases over 15 years

Fundamento. El feocromocitoma es un tumor productor de catecolaminas que procede de las células cromafines del sistema nervioso simpático. El 80-85% se localiza en la médula adrenal. El diagnóstico se confirma con la determinación de catecolaminas y metanefrinas en plasma y orina. El diagnóstico de localización debe realizarse una vez confirmado el diagnóstico bioquímico, preferentemente mediante tomografía computarizada y/o resonancia magnética. El tratamiento de elección es la cirugía vía laparoscópica. Material y métodos. Revisión de las historias clínicas de los pacientes con diagnóstico anatomo-patológico de feocromocitoma en los servicios de Anatomía Patológica del Complejo Hospitalario de Navarra entre los años 1996 y 2010. Se realiza el análisis descriptivo de los resultados mediante el programa estadístico SPSS. Resultados. Esta serie está formada por 43 pacientes con diagnóstico anatomo-patológico de feocromocitoma durante los últimos 15 años. La edad media de presentación es de 47 años. Entre los más jóvenes hay condensación de pacientes con determinados síndromes genéticos. El método de imagen más empleado ha sido la tomografía computarizada. Encontramos resultados contradictorios en cuanto al empleo de medicación preoperatoria. El comportamiento en todos los casos ha sido benigno. Conclusiones. Creemos conveniente realizar estudio genético en pacientes menores de 20 años de edad. Los parámetros con mayor sensibilidad para el diagnóstico han sido normetanefrina y metanefrina en orina. El único tratamiento curativo es la cirugía, que debería realizarse preferentemente vía laparoscópica(AU)

Background. The pheochromocytoma is a catecholamine secreting tumour derived from chromaffin cells of the sympathetic nervous system. Eighty to eighty-five percent of these tumours are localized in the adrenal medulla. When pheocromocytomas are found outside the adrenal gland they are referred to as extra-adrenal pheochromocytomas or paragangliomas. The diagnosis is confirmed by elevation of catecholamines and the metanephrinesin blood plasma and urine. Localization of the tumour should be done following biochemical diagnosis by means of CT scan and/or MRI. The treatment of choice is tumour resection by laparoscopic surgery. Material and methods. A review was made of all patient medical histories diagnosed with pheochromocytoma confirmed by the pathology reports of Pathologicalanatomy of the Navarre hospital Complex (Anatomía patológica del Complejo hospitalario de Navarra A y B)between 1996 to 2010. Descriptive analysis was made using the IBM SPSS statistics program. Results. Our series consists of 43 patients diagnosed with pheochromocytoma over a span of 15 years. The average age on presentation was 47 years. Among the younger patients specific genetic syndromes were found. Computerized tomography was the most widely used method of localization. Contradictory results were found regarding perioperative medical management protocols. All pheocromocytoma tumours in this series were benign. Conclusions. It is advisable to carry out a genetic study on patients under twenty. The biochemical indicators with the greatest diagnostic sensitivity were the levels of normetanephrine and metanephrine in urine. Surgery was the only treatment option(AU)

¿Está indicado el examen sistemático de la función tiroidea durante el embarazo? / Is thyroid function screening warranted during pregnancy?

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