Percepção dos acadêmicos de odontologia quanto à conduta clínica frente às recessões gengivais / Perception of academics of dentistry front to clinical conduct resections gingival

Objetivo: avaliar o conhecimento e a conduta clínica dos discentes de Odontologia frente ao tratamento das recessões gengivais. Metodologia: estudo qualitativo observacional, cujos dados foram coletados através da aplicação de um questionário entre os acadêmicos de Odontologia do último período de uma instituição de ensino. Resultados: 46,5% dos pesquisados conhecem a classificação de Miller, mas apenas 11,6% conheciam o seu pior prognóstico; a maioria dos entrevistados considera como principal indicação para o recobrimento radicular a estética associada à sensibilidade; e apenas 7% recomendariam o recobrimento radicular a partir de retalhos reposicionados. Conclusão: o conhecimento e a conduta clínica adotada pelos entrevistados mostraram-se prudentes, pois os acadêmicos adotariam medidas terapêuticas conservadoras, que acarretariam poucos prejuízos estéticos e teciduais aos pacientes.

The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal Plant Plumeria rubra: Involvement of the Latex Proteins in the NO/cGMP/K ATP Signaling Pathway.

Plumeria rubra (Apocynaceae) is frequently used in folk medicine for the treatment of gastrointestinal disorders, hepatitis, and tracheitis, among other infirmities. The aim of this study was to investigate the gastroprotective potential of a protein fraction isolated from the latex of Plumeria rubra (PrLP) against ethanol-induced gastric lesions and describe the underlying mechanisms. In a dose-dependent manner, the pretreatment with PrLP prevented ethanol-induced gastric lesions in mice after single intravenous administration. The gastroprotective mechanism of PrLP was associated with the involvement of prostaglandins and balance of oxidant/antioxidant factors. Secondarily, the NO/cGMP/KATP pathway and activation of capsaicin-sensitive primary afferents were also demonstrated as part of the mechanism. This study shows that proteins extracted from the latex of P. rubra prevent gastric lesions induced in experimental animals. Also, the results support the use of the plant in folk medicine.

Inflammation induced by phytomodulatory proteins from the latex of Calotropis procera (Asclepiadaceae) protects against Salmonella infection in a murine model of typhoid fever.

OBJECTIVE AND DESIGN: Laticifer proteins (LP) of Calotropis procera were fractionated by ion-exchange chromatography, and the influence of a sub-fraction (LP(PI)) on the inflammatory response of Swiss mice challenged by Salmonella enterica Ser. Typhimurium was investigated. METHODS: Mice (n = 10) received LP(PI) (30 or 60 mg/kg) in a single inoculum by the intraperitoneal route 24 h before infection. To investigate the relevance of the proteolytic activity, three additional groups were included: the first one received heat-treated LP (30 mg/kg-30 min at 100 °C), the second received LP (30 mg/kg) inactivated by iodoacetamide, and a control group received only phosphate-buffered saline (PBS). RESULTS: The survival rate reached 100 % in mice treated with LP(PI) and was also observed with the other treatment, whereas the PBS group died 1-3 days after infection. The neutrophil infiltration into the peritoneal cavity of pretreated mice was enhanced and accompanied by high bacterial clearance from the bloodstream. Tumor necrosis factor-alpha mRNA transcripts, but not interferon-gamma, were detected early in spleen cells of pretreated mice after infection; however, the nitric oxide contents in the bloodstream were decreased in comparison to the PBS group. CONCLUSIONS: The inflammatory stimulus of C. procera proteins increased phagocytosis and balanced the nitric oxide release in the bloodstream, preventing septic shock induced by Salmonella infection.

EU fiz com que o povo que a tomara por sonho tornasse a acreditar nela: as propostas da Seçao Geológica da Comissao Científica de Exploraçao (1856) / No disponible

En 1856, en Brasil, existió la iniciativa pionera de formar una comisión científica, compuesta sólo por científicos nacionales, con el objetivo de explorar las provincias del norte y del nordeste del país y formar un acervo de objetos naturales y artificiales brasileros. Este trabajo presenta un breve análisis de las Instrucciones de Viaje de la Sección Mineralógica de la Comisión

In 1856, at Brazil, were create the first scientific commition with brazilian naturalist only, to do a scientific exploration in the north of the country and collect objects to the Museu Nacional, in Rio de Janeiro. In these paper I mada the analysis of the Traveling Instruction of the Geological and Mineralogical Section, written by Guilherme Schüch de Capanema