Outcome analysis of patients with early infiltrating breast carcinoma treated by surgery with intraoperative evaluation of surgical margins.

AIM: The purpose of this study was to determine the effect of intraoperative evaluation of surgical margins (IESM) on the local recurrence rate, the occurrence of distant metastases and survival in invasive breast carcinoma (T1-2). METHODS: Two groups of patients were compared: a control group of 149 patients treated by classical quadrantectomy without IESM, and an IESM study group of 102 patients submitted to surgical treatment guided by this procedure. In the IESM group 64 quandrantectomies, 33 enlarged quadrantectomies and five mastectomies were performed. RESULTS: In the control group 17 local recurrences (11.4%), 49 distant metastases (39.2%) and 43 deaths (31.5%) occurred; in the IESM group there were no local recurrences, nine distant metastases occurred (8.8%) and three patients died (2%). Adjuvant treatment was the same in both groups. The survival curves were estimated by the Kaplan-Meier method and compared with the log-rank test. The curves were censored at 99 months of follow-up for adequate comparison because the follow-up period was different in the two groups. Significant differences in local recurrence-free survival and distant metastasis-free survival curves (P = 0.001) in favor of the study group were observed. The overall survival curve of the IESM group was also superior, but statistical analysis revealed only a strong tendency without significance (P = 0.06). CONCLUSION: Treatment of early infiltrating breast carcinoma guided by IESM results in a better prognosis.

Tratamento endócrino adjuvante do câncer de mama / Adjuvant endocrine treatment in breast cancer

Os autores apresentam revisão da literatura acerca dos procedimentos utilizados na terapêutica endócrina adjuvante do câncer de mama, com o propósito de obter melhores taxas de intervalo livre da doença e da sobrevida global. Inicialmente, analisam estudos epidemiológicos, que evidenciam o papel dos estrógenos endógenos na patogenia e na proliferação da neoplasia,assim como a importância da presença de receptores de estrógenos...

Reconstrucao mamaria pos-mastectomia com tecido autogeno: avaliacao comparativa de resultados e complicacoes / Breast reconstruction with autologous tissue results and complications

A reconstrucao mamaria por mastectomia com tecido autogeno e advogada por uma serie de autores oferecendo melhores resultados a longo prazo quando comparados aos materiais aloplasticos. Entre as opcoes, o retalho transverso do musculo reto abdominal (TRAM pediculado e microcirurgico) apresenta...

Mastopatia fibrocistica / Fibrocistica breast disease

A mastopatia fibrocistica se caracteriza por mamaria associada a graus variados de espessamento do parenquima. E o diagnostico mais comum em ambulatorios da especialidade. Gera ansiedade nas pacientes pela sua eventual evolucao para o cancer. A terapeutica e baseada principalmente na orientacao verbal e psicotarapia de apoio. Em casos selecionados pode-se indicar terapia medicamentosa com uso de progesterona, diuretico, tamoxifen, bromoergocriptina e danazol. A cirurgia e praticada em casos excepcionais.