Niveles de exposición a arsénico en agua de bebida y riesgo relativo de cáncer de piel, en Máximo Paz, Santa Fe, Argentina. Período 2001-2005

El Arsénico en el agua de bebida es un importante problema ambiental en amplias zonas de Argentina. El cáncer, especialmente de piel, es uno de los riesgos asociados con el consume crónico de agua con elevados tenores de arsénico. Los valores máximos recomendados por la Organización Mundial de la Salud son de 0.010mg/l. La Ley Provincial Nº 11.220 de 1995 obliga a todos los servicios de agua potable a suministrar agua de bebida con concentraciones de arsénico de 0.050 mg/l (Límite Recomendado) o menores, aunque las normas en vigencia admiten plazos para alcanzar condiciones normales de operación y el límite recomendado, período durante el cual debe el prestador cumplir con el "límite obligatorio" de 0.100 mg/l. Estos valores pueden significar riesgos para la salud de las poblaciones expuestas. Se evalúa el riego relativo para desarrollar cáncer de piel en la población rural de Máximo Paz

Niveles de exposición a arsénico en agua de bebida y riesgo relativo de cáncer de piel, en Máximo Paz, Santa Fe, Argentina. Período 2001-2005

El Arsénico en el agua de bebida es un importante problema ambiental en amplias zonas de Argentina. El cáncer, especialmente de piel, es uno de los riesgos asociados con el consume crónico de agua con elevados tenores de arsénico. Los valores máximos recomendados por la Organización Mundial de la Salud son de 0.010mg/l. La Ley Provincial Nº 11.220 de 1995 obliga a todos los servicios de agua potable a suministrar agua de bebida con concentraciones de arsénico de 0.050 mg/l (Límite Recomendado) o menores, aunque las normas en vigencia admiten plazos para alcanzar condiciones normales de operación y el límite recomendado, período durante el cual debe el prestador cumplir con el "límite obligatorio" de 0.100 mg/l. Estos valores pueden significar riesgos para la salud de las poblaciones expuestas. Se evalúa el riego relativo para desarrollar cáncer de piel en la población rural de Máximo Paz

[Esophagitis associated with use of alendronate in 5 postmenopausic patients]. / Esofagitis asociada con el uso de alendronato en 5 pacientes posmenopáusicas.

The bisphosphonate, alendronate sodium (e.g. Fosamax) is a bone resorption inhibitor used to treat postmenopausal osteoporotic women and osseous Paget's disease. Esophagitis is one of the adverse effects (AE) associated to its use. Five (5) patients with alendronate-associated esophagitis assisted in the Gastroenterologic Center, Rosario, Argentina, between October 1996 and December 1999 are described. The aim is to correlate the clinical, endoscopic and histopathological findings in 5 women (ages 57-71) complaining for upper digestive symptoms (dysphagia, epigastralgia, retrosternal pain.). All had osteoporosis treated with alendronate 10 mg/day and received detailed instructions about how to take the medication. The time from the beginning of alendronate intake and the appearance of the symptoms was elapsed 30, 35, 67, 85 and 90 days. The esophagitis was graded according to the Savary-Miller Classification. The videoscopy disclosed esophagitis of III and IV grades. Three patients had also antral and antroduodenal lesions, one of them associated to Helicobacter Pylori. Anatomopathologic findings confirm esophagitis and esophagic ulceration. Some authors claim that bisphosphonates as a new class of gastrotoxic drugs with AE similar to aspirin. Even when it is administrated according to the instructions of the manufacturers it should be used with caution. Our contribution emphasize the importance of this AE and suggest measures to diminish or suppress them, and take into consideration those patients who are taking aspirin. With alendronate, as well as with other potentially corrosive agents, is very important to take in mind the measures to prevent AE.

Esofagitis asociada con el uso de alendronato en 5 pacientes posmenopáusicas / Esophagitis associated with use of alendronate in 5 postmenopausic patients

The biphosphonate, alendronate sodium (e.g. Fosamax) is a bone resorption inhibitor used to treat posmenopausal osteoporotic women and osseous Pagets disease. Esophaghitis is one of the adverse effects (AE) associated to its use. Five (5) patients with alendronate-associated esophagitis assisted in the Gastroenterologic Center, Rosario, Argentina, between October 1996 and December 1999 are described. The aim is to correlate the clinical, endoscopic and histopathological findings in 5 women (ages 57-71) complained for upper digestive symptoms (disphagia, epigastrialgia, retroesternal pain). All had osteoporosis treated with alendronate 10 mg/day and received detailed instructions about how to take the medication. The time from the beginning of alendronate intake and the appearence of the symptoms was elapsed 30, 35, 67, 85 and 90 days. The esophagitis was graded according to the Savary-Miller Classification. The videoscopy disclosed esophagitis of III and IV grades. Three patients has also antral and antroduodenal lesions, one of them associated to Helicobacter pylori. Anatomopathological findings confirm esophagitis and esophagic ulceration. Some authors claim that disphosphonates as a new class of gastrotoxic drugs with AE similar to aspirin. Even when it is administrated according to the instructions of the manufactures it should be used with caution. Our contribution emphazise the importance of this AE and suggest measures to diminish or suppres them, and take into consideration those patients who are taking aspirin. With alendronate, as well as with other potentially corrosive agents, is very important to take in mind the measures to prevent AE. (Au)

Esofagitis asociada con el uso de alendronato en 5 pacientes posmenopáusicas. / [Esophagitis associated with use of alendronate in 5 postmenopausic patients]

The bisphosphonate, alendronate sodium (e.g. Fosamax) is a bone resorption inhibitor used to treat postmenopausal osteoporotic women and osseous Pagets disease. Esophagitis is one of the adverse effects (AE) associated to its use. Five (5) patients with alendronate-associated esophagitis assisted in the Gastroenterologic Center, Rosario, Argentina, between October 1996 and December 1999 are described. The aim is to correlate the clinical, endoscopic and histopathological findings in 5 women (ages 57-71) complaining for upper digestive symptoms (dysphagia, epigastralgia, retrosternal pain.). All had osteoporosis treated with alendronate 10 mg/day and received detailed instructions about how to take the medication. The time from the beginning of alendronate intake and the appearance of the symptoms was elapsed 30, 35, 67, 85 and 90 days. The esophagitis was graded according to the Savary-Miller Classification. The videoscopy disclosed esophagitis of III and IV grades. Three patients had also antral and antroduodenal lesions, one of them associated to Helicobacter Pylori. Anatomopathologic findings confirm esophagitis and esophagic ulceration. Some authors claim that bisphosphonates as a new class of gastrotoxic drugs with AE similar to aspirin. Even when it is administrated according to the instructions of the manufacturers it should be used with caution. Our contribution emphasize the importance of this AE and suggest measures to diminish or suppress them, and take into consideration those patients who are taking aspirin. With alendronate, as well as with other potentially corrosive agents, is very important to take in mind the measures to prevent AE.

Esofagitis asociada con el uso de alendronato en 5 pacientes posmenopáusicas / Esophagitis associated with use of alendronate in 5 postmenopausic patients

The biphosphonate, alendronate sodium (e.g. Fosamax) is a bone resorption inhibitor used to treat posmenopausal osteoporotic women and osseous Paget's disease. Esophaghitis is one of the adverse effects (AE) associated to its use. Five (5) patients with alendronate-associated esophagitis assisted in the Gastroenterologic Center, Rosario, Argentina, between October 1996 and December 1999 are described. The aim is to correlate the clinical, endoscopic and histopathological findings in 5 women (ages 57-71) complained for upper digestive symptoms (disphagia, epigastrialgia, retroesternal pain). All had osteoporosis treated with alendronate 10 mg/day and received detailed instructions about how to take the medication. The time from the beginning of alendronate intake and the appearence of the symptoms was elapsed 30, 35, 67, 85 and 90 days. The esophagitis was graded according to the Savary-Miller Classification. The videoscopy disclosed esophagitis of III and IV grades. Three patients has also antral and antroduodenal lesions, one of them associated to Helicobacter pylori. Anatomopathological findings confirm esophagitis and esophagic ulceration. Some authors claim that disphosphonates as a new class of gastrotoxic drugs with AE similar to aspirin. Even when it is administrated according to the instructions of the manufactures it should be used with caution. Our contribution emphazise the importance of this AE and suggest measures to diminish or suppres them, and take into consideration those patients who are taking aspirin. With alendronate, as well as with other potentially corrosive agents, is very important to take in mind the measures to prevent AE.

Valoración de marcadores de exposición al plomo en diagnóstico y vigilancia

Los efectos tóxicos producidos por el plomo son conocidos desde hace más de 2000 años y a pesar de ello continúa siendo un importante tema de salud pública en la mayoría de países industrializados . Resulta destacable considerar que es la enfermedad laboral de origen tóxico más frecuente en nuestro medio y que su incidencia es elevada. Nuestro aporte tiende a actualizar el conocimiento sobre los distintos marcadores de exposición al plomo y valorar su utilidad. La muestra con la que se trabajó estaba constituida por 139 personas atendidas en el Servicio de Toxicología del Sanatorio de Niños (Sertox), entre enero de 1990 y agosto de 1998

Valoración de marcadores de exposición al plomo en diagnóstico y vigilancia

Los efectos tóxicos producidos por el plomo son conocidos desde hace más de 2000 años y a pesar de ello continúa siendo un importante tema de salud pública en la mayoría de países industrializados . Resulta destacable considerar que es la enfermedad laboral de origen tóxico más frecuente en nuestro medio y que su incidencia es elevada. Nuestro aporte tiende a actualizar el conocimiento sobre los distintos marcadores de exposición al plomo y valorar su utilidad. La muestra con la que se trabajó estaba constituida por 139 personas atendidas en el Servicio de Toxicología del Sanatorio de Niños (Sertox), entre enero de 1990 y agosto de 1998

Necrosis cutanea por loxosceles. / Skin necrosis by loxosceles bites

La picadura de loxosceles puede causar ulceraciones de la piel, hemolisis intravascular y muerte. Se presenta un caso clinico de una lactante de 44 dias de edad, con diez lesiones ulcero-necroticas en abdomen inferior, zona perineal y zona dorso lumbar. Presento ademas fiebre, plaquetopenia, anemia y esplenomegalia. Se hace un resumen de los procesos patologicos conocidos, hallazgos clinicos y metodos recomendados de tratamiento. Se senala la importancia de la falta de correlacion entre la sintomatologia dermica que fue grave y los sintomas generales, moderados. Se resalta la importancia del conocimiento del cuadro clinico ya que la arana es raramente encontrada y muy dificil su identificacion

Necrosis cutanea por loxosceles. / Skin necrosis by loxosceles bites

La picadura de loxosceles puede causar ulceraciones de la piel, hemolisis intravascular y muerte. Se presenta un caso clinico de una lactante de 44 dias de edad, con diez lesiones ulcero-necroticas en abdomen inferior, zona perineal y zona dorso lumbar. Presento ademas fiebre, plaquetopenia, anemia y esplenomegalia. Se hace un resumen de los procesos patologicos conocidos, hallazgos clinicos y metodos recomendados de tratamiento. Se senala la importancia de la falta de correlacion entre la sintomatologia dermica que fue grave y los sintomas generales, moderados. Se resalta la importancia del conocimiento del cuadro clinico ya que la arana es raramente encontrada y muy dificil su identificacion