RESUMO
The effect of acute venous hypertension on the extravasation of plasma proteins, erythrocytes, and leukocytes into regional lymph was studied in the dog hindlimb. Although the lymph protein transport sharply rose with hindlimb phlebohypertension, capillary permeability was unchanged with retention in draining lymph of a normal proportion of large to small molecular weight proteins. Leukocyte transport also increased initially but then progressively decreased despite persistent venous hypertension. Lymph transport of erythrocytes was also high during venous hypertension but in contrast to white cells, it remained at that level as long as venous pressure was elevated. These findings suggest that different pathways and mechanisms are involved in the capillary extravasation of plasma proteins and cells capable of intrinsic motility (i.e., leukocytes) and those without independent motion (i.e., erythrocytes).
