Entanglement-Assisted Entanglement Purification.

The efficient generation of high-fidelity entangled states is the key element for long-distance quantum communication, quantum computation, and other quantum technologies, and at the same time the most resource-consuming part in many schemes. We present a class of entanglement-assisted entanglement purification protocols that can generate high-fidelity entanglement from noisy, finite-size ensembles with improved yield and fidelity as compared to previous approaches. The scheme utilizes high-dimensional auxiliary entanglement to perform entangling nonlocal measurements and determine the number and positions of errors in an ensemble in a controlled and efficient way, without disturbing the entanglement of good pairs. Our protocols can deal with arbitrary errors, but are best suited for few errors, and work particularly well for decay noise. Our methods are applicable to moderately sized ensembles, as will be important for near term quantum devices.

Multipartite state generation in quantum networks with optimal scaling.

We introduce a repeater scheme to efficiently distribute multipartite entangled states in a quantum network with optimal scaling. The scheme allows to generate graph states such as 2D and 3D cluster states of growing size or GHZ states over arbitrary distances, with a constant overhead per node/channel that is independent of the distance. The approach is genuine multipartite, and is based on the measurement-based implementation of multipartite hashing, an entanglement purification protocol that operates on a large ensemble together with local merging/connection of elementary building blocks. We analyze the performance of the scheme in a setting where local or global storage is limited, and compare it to bipartite and hybrid approaches that are based on the distribution of entangled pairs. We find that the multipartite approach offers a storage advantage, which results in higher efficiency and better performance in certain parameter regimes. We generalize our approach to arbitrary network topologies and different target graph states.

Long-Range Big Quantum-Data Transmission.

We introduce an alternative type of quantum repeater for long-range quantum communication with improved scaling with the distance. We show that by employing hashing, a deterministic entanglement distillation protocol with one-way communication, one obtains a scalable scheme that allows one to reach arbitrary distances, with constant overhead in resources per repeater station, and ultrahigh rates. In practical terms, we show that, also with moderate resources of a few hundred qubits at each repeater station, one can reach intercontinental distances. At the same time, a measurement-based implementation allows one to tolerate high loss but also operational and memory errors of the order of several percent per qubit. This opens the way for long-distance communication of big quantum data.

IL-4 downregulates expression of the target receptor CD30 in neoplastic canine mast cells.

CD30 is a novel therapeutic target in human mast cell (MC) neoplasms. In this 'comparative oncology' study, we examined CD30 expression and regulation in neoplastic canine MC using a panel of immunomodulatory cytokines [interleukin-2 (IL-2), IL-4, IL-5, IL-6, IL-13 and stem cell factor (SCF)] and the canine mastocytoma cell lines NI-1 and C2. Of all cytokines tested IL-4 was found to downregulate expression of CD30 in NI-1 and C2 cells. We also found that the CD30-targeting antibody-conjugate brentuximab vedotin induces growth inhibition and apoptosis in both MC lines. Next, we asked whether IL-4-induced downregulation of CD30 interferes with brentuximab vedotin-effects. Indeed, pre-incubation of NI-1 cells with IL-4 decreased responsiveness towards brentuximab vedotin. To overcome IL-4-mediated resistance, we applied drug combinations and found that brentuximab vedotin synergizes with the Kit-targeting drugs masitinib and PKC412 in inhibiting growth of NI-1 and C2 cells. In summary, CD30 is a new marker and IL-4-regulated target in neoplastic canine MC.

Type of edema in posterior reversible encephalopathy syndrome depends on serum albumin levels: an MR imaging study in 28 patients.

PRES is a clinicoradiologic entity, combining seizures, blindness, and coma with MR imaging findings of predominantly vasogenic and occasional cytotoxic edema. In this clinical report, we determined the type of edema by using DWI and FLAIR sequences on MR imaging as well as ADC maps in 28 patients with PRES. The neuradiologic findings were correlated with levels of serum albumin, which is a main contributor to colloid osmotic pressure and vascular integrity. The presence of vasogenic edema was significantly associated with decreased serum albumin levels, which may be a particular risk factor for the development of PRES.