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5.
Probl Endokrinol (Mosk) ; 29(1): 11-5, 1983.
Artigo em Russo | MEDLINE | ID: mdl-6835951

RESUMO

The blood and urine porphyrin content and porphyrin biosynthesis in the red blood cells after delta-amino levulinic acid (ALA) incubation, porphobilinogen and non-consumed ALA levels, porphobilinogen-synthetase activity were studied in 86 patients divided into 3 groups depending on diabetes severity. Porphyrin separation was investigated by means of thin-layer chromatography. It was found that porphyrin biosynthesis decreases in all diabetics at the early periods of the disease, not depending on its severity. Porphyrin biosynthesis is lowered during a phase of chronic renal insufficiency in patients with diabetic nephropathy. Porphyrin metabolic disorder is caused by hepatic dysfunction and diabetic nephropathy development.


Assuntos
Diabetes Mellitus/metabolismo , Porfirinas/biossíntese , Adulto , Idoso , Diabetes Mellitus/patologia , Nefropatias Diabéticas/metabolismo , Nefropatias Diabéticas/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Mitocôndrias Hepáticas/metabolismo , Sintase do Porfobilinogênio/metabolismo , Pielonefrite/metabolismo , Pielonefrite/patologia
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