Assuntos
Rinite Alérgica Perene , Rinite Alérgica Sazonal , Adolescente , Corticosteroides/uso terapêutico , Adulto , Testes de Provocação Brônquica , Criança , Pré-Escolar , Antagonistas Colinérgicos/uso terapêutico , Cromolina Sódica/uso terapêutico , Dessensibilização Imunológica , Diagnóstico Diferencial , Antagonistas dos Receptores Histamínicos/uso terapêutico , Humanos , Rinite Alérgica Perene/diagnóstico , Rinite Alérgica Perene/terapia , Rinite Alérgica Sazonal/diagnóstico , Rinite Alérgica Sazonal/terapia , Testes Cutâneos , Tomografia Computadorizada por Raios XRESUMO
Thirty patients with perennial vasomotor rhinitis were submitted to pharmacological tests to assess the autonomic responsiveness of extra-nasal and intra-nasal receptors to isoprenaline and phenylephrine by infusion, and to evaluate the effect of 14-days' treatment with mequitazine (5 mg twice daily) and placebo on clinical symptoms and on autonomic sensitivity. Isoprenaline induced a similar tachycardia in all patients, more pronounced than that observed in normal subjects, at the different times of testing, and also an increase in nasal resistance. With phenylephrine, marked bradycardia was observed, reflecting high vagal baroreflex sensitivity, and a transient decrease in nasal resistance was obtained. Mequitazine improved significantly the clinical symptoms but did not modify the autonomic receptivity. It is suggested that in patients with vasomotor rhinitis an autonomic dysfunction may play a role in a predisposing factor in nasal hyperreactivity with non-specific histamine release.
Assuntos
Sistema Nervoso Autônomo/efeitos dos fármacos , Fenotiazinas/uso terapêutico , Rinite Vasomotora/tratamento farmacológico , Adolescente , Adulto , Método Duplo-Cego , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Isoproterenol , Masculino , Pessoa de Meia-Idade , Mucosa Nasal/metabolismo , Fenilefrina , Placebos , Pulso Arterial/efeitos dos fármacos , Rinite Vasomotora/fisiopatologiaRESUMO
The authors report a new case of pseudo-tumoral nodular amyloidosis of the lungs. The amyloid nodules being discovered during a surgical procedure for an adenocarcinoma of the lower oesophagus. The histopathological study of the nodules confirmed their amyloid origin and allowed to precise their histochemical features.
Assuntos
Amiloidose/diagnóstico , Pneumopatias/diagnóstico , Idoso , Amiloidose/patologia , Diagnóstico Diferencial , Humanos , Pneumopatias/patologia , Neoplasias Pulmonares/diagnóstico , MasculinoRESUMO
The authors report the variations in calcaemia and in circulating immunoreactive PTH produced by the intramuscular injection of 5 units of porcine calcitonin in normal subjects and in patients suffering from osteoporosis or Paget's disease. After having determined the levels of 25-hydroxy-vitamin D circulating in the different groups, the authors note that comparison of these variations makes it possible to regroup the different types of reaction following the injection of the hypocalcaemic hormone. In patients suffering from pure osteoporosis, hypocalcaemia was slow to appear, was of moderate intensity, but was prolonged. The osteoporo-malacia patients did not produce a specific reaction and certain of them appeared "insensitive" to calcitonin. Results obtained in patients with Paget's disease confirm the hypocalaemic action of calcitonin even at a low dosage. With this test, the authors hope to contribute to studies of demineralizing affections and to overcoming them.
