[Quantitative structure-hypoglycemic activity relationships of some thiazolidine and imidazolidine-2,4-diones]. / Relations quantitatives structure-activité hypoglycémiante de quelques thiazolidine- et imidazolidine-2,4-diones.

Quantitative structure-activity relationships are described for twenty six title compounds. Five compounds exhibit a significant hypoglycemic activity like insulin used as standard. The aim of the present paper is to investigate the contribution of the different substituents in the biological activity. The application of Fujita-Ban and Hansch models has shown that lipophilic and electronic parameters seem to be the best explanation of variance of biological data.

[Antifungal activity of 5-benzilidene pyrrolone and furanone derivatives]. / Activité antifongique de dérivés benzilidène-5 pyrrolones et furannones.

The antifungal activity against Neurospora crassa of some 5-benzilidene pyrrolone and furanone derivatives was realised. Relations between the structure and this biological activity are established with Fujita-Ban and Hansch methods. The preponderant part of lipophilicity, resonance effect and E or Z configurations have been showed.