[The dependence of the frequency of stable and unstable chromosome aberrations on the dose of the irradiation of human lymphocytes in vitro]. / Zavisimost' chastoty stabil'nykh i nestabil'nykh aberratsii khromosom ot dozy oblucheniia limfotsitov cheloveka in vitro.

Two methods (FISH and Giemsa) were used to estimate the frequency of stable and unstable chromosome aberrations in human lymphocytes exposed to gamma-irradiation in vitro in the dose range of 0.1 to 1.5 Gy. The DNA-probes specific to the chromosomes 1, 4, and 12 were used in combination with a pancentromeric probe. It was revealed that the dose-effect dependences for translocations (FISH) and dicentrics (FISH and Giemsa) were similar and could be adequately described by a linear-quadratic function.

[The cytogenetic examination of children in the Saint Petersburg region who suffered as a result of the accident at the Chernobyl Atomic Electric Power Station. The frequency of unstable chromosome aberrations in the peripheral blood lymphocytes]. / Tsitogeneticheskoe obsledovanie detei Sankt-Peterburgskogo regiona, postradavshikh v rezul'tate avarii na ChAES. Chastota nestabil'nykh khromosomnykh aberratsii v limfotsitakh perifericheskoi krovi.

Cytogenetic study of 90 children suffered from the Chernobyl accident was carried out. The rate of unstable chromosome aberrations in lymphocytes was higher in groups of children whose parents took part in amelioration work after the Chernobyl accident, children evacuated from the contaminated areas and children of patients received antitumor radio- and chemotherapy as compared to nonexposed children. The increase was due mainly to single fragments. In the group of children evacuated from contaminated areas the rate of exchanges was also increased.

[The results of a cytogenetic examination performed in different years on those who worked in the cleanup of the aftermath of the accident at the Chernobyl Atomic Electric Power Station]. / Rezul'taty tsitogeneticheskogo obsledovaniia likvidatorov posledstvii avarii na ChAES, provedennogo v raznye gody.

Persons participated in the Chernobyl accident amelioration in the years of 1986-1987 were examined cytogenetically either in 1987 (group 1) or in 1990-1992 (group 2). The frequency of chromosome aberrations in cultured peripheral lymphocytes is found to be significantly lower in group 2 in comparison with group 1, being increased in both exposed groups as compared to the control one. The data are obtained in favour of hypothesis on chromosome instability of exposed individuals. On the base of cytogenetic data the collective dose received by amelioraters was calculated.