[Appreciation of scientific researcher life of Prof. Dr. I. Rácz]. / Prof. Dr. Rácz István tudományos kutatói pályájának mé ltatása.

Authors summarized the scientific career of Prof. Dr. István Rácz, who died last year. His many-sided work was shown first of all emphasizing his research activity. The innovative solutions of him concerning to the preparation of new, controlled release dosage forms, allows nowadays the production of such drugs, which are still on national and international market. At one time professor of the Pharmaceutical Institute he gained long term merit on the field of pharmaceutical technology.

[Study of the acid buffering capacity of dietary components regarding food-drug interactions]. / Táplálék összetevók in vitro savtompító képességének vizsgálata a gyógyszer-ételinterakció összefüggésében.

Food intake is known to exert numerous effects on drug pharmacokinetics through a variety of mechanisms, and for some medicinal compounds, food-drug interaction could prove of crucial clinical importance. As for acid-labile drugs, bioavailability studies performed in both fasting and fed states are considered essential. A simple and fast in vitro procedure using the USP Dissolution Apparatus II (paddle method) was applied to study acid buffering capacity of food components under simulated in vivo environment. As expected, carbohydrates (starch, sugars) and fat (oil emulsions) failed to show considerable acid buffering capacities, while protein-containing components (milk powder, gelatine) showed significant acid buffering capacity. The results of an in vitro model applying the so-called "standard meal" were in correlation with data obtained from studies performed in healthy volunteers. Nevertheless, in vitro models simulating both the fed and the fasting states in the GIT help explore factors related to food effect on drug dissolution; and consequently, achieve better insight into postprandial drug behaviour.

[Comparative study of combined local treatment (sulfadimidine, metronidazole and nystatin) and the standard monotherapy in uncomplicated bacterial vaginosis]. / Szövódménymentes bakteriális vaginosis kombinált hüvelyi kezelésének (szulfadimidin, metronidazol és nystatin) és a standard monoterápiák összehasonlító vizsgálata.

Comparative, in vivo, human, prospective, single blind, clinical and microbiological diagnoses based and randomised study of the treatment of uncomplicated bacterial vaginosis with two forms of combined (metronidazole + nystatin + sulfadimidin) vaginal suppositories (laminated and mixed containing the same ingredients) and the standard preparations available in the Hungarian market (Dalacin vaginal cream and Klion vaginal suppository). The examinations involved 60 volunteers and were performed in the Gynecological Outpatient Clinic of the Council of Erd, the microbiological samples were examined at Saint Rókus Hospital in Budapest. The combined treatment was better tolerated and resulted in normal vaginal pH significantly more often at the same rate of recovery. The combined treatment is simultaneously effective in cases of the most prevalent coinfections too.