1.
Bioorg Med Chem Lett
; 9(16): 2359-64, 1999 Aug 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10476869
RESUMO
The structure-activity relationships (SAR) of a novel class of Src SH2 inhibitors are described. Variation at the pY+1 and pY+3 side chain positions using 2,4- and 2,5-substituted thiazoles and 1,2,4-oxadiazoles as scaffolds resulted in inhibitors that bound as well as the standard tetrapeptide Ac-pYEEI-NH2.
