RESUMO
The authors report on three cases of severe P. falciparum malaria successfully treated by iv quinine and exchange transfusion. Serum concentrations of Tumor Necrosis Factor (TNF) were determined before and during treatment. After an initial decrease, serum levels of TNF remained markedly elevated during the first 48 hours despite exchange transfusion. Though exchange transfusion accelerates the elimination of parasites from the blood, it seems to have no immediate effects on reducing serum levels of cytokines such as TNF.
Assuntos
Transfusão Total , Malária Falciparum/sangue , Quinina/uso terapêutico , Fator de Necrose Tumoral alfa/análise , Adulto , Quimioterapia Adjuvante , Humanos , Infusões Intravenosas , Malária Falciparum/tratamento farmacológico , Malária Falciparum/terapia , Masculino , Pessoa de Meia-Idade , Quinina/administração & dosagemRESUMO
Anticardiolipin antibodies (ACA) were determined in 72 heavily transfused haemophiliacs, 43 HIV-positive and 29 HIV-negative. The presence of ACA was detected in 10 patients, all of them infected by HIV: 8 in CDC II, 1 in CDC III and 1 in CDC IV. The comparison with alterations of other laboratory markers in HIV-infected patients did not show any statistically significant difference between ACA-negative and -positive patients. In summary, ACA were found only in HIV-infected haemophiliacs. In this subgroup of patients the presence of ACA was not associated with progression to AIDS.
Assuntos
Anticorpos/sangue , Cardiolipinas/imunologia , Soropositividade para HIV/imunologia , Hemofilia A/imunologia , Síndrome da Imunodeficiência Adquirida/imunologia , Transfusão de Sangue , Infecções por HIV/imunologia , Hemofilia A/terapia , Humanos , Imunoglobulina A/análise , Imunoglobulina G/análise , Imunoglobulina M/análiseRESUMO
Two out of three patients with acute myeloid leukemia responded to treatment with small subcutaneous doses of cytosine-arabinoside alone. Although marked cytopenia may transiently occur this treatment has no other side effects and is simple to administer. It may therefore be useful for elderly patients. Morphological studies and indirect evidence suggest that this schedule, dosage and route of administration for cytosine-arabinoside may promote differentiation within the malignant clone rather than acting as a cytotoxic agent.
