1.
Bioorg Med Chem Lett
; 15(19): 4230-4, 2005 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16055331
RESUMO
A series of 2-alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles were synthesized and evaluated for their 5-HT6 activity. The most potent agonist in this series was 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole with an IC50=7.4 nM in 3H-LSD binding and an EC50=1.0 nM in a functional assay measuring production of cyclic AMP.
