Community responses to LGBT+ adults with intellectual and developmental disabilities during the COVID-19 confinement in Madrid.

A group of 50 people with intellectual and developmental disabilities (IDDs) as well as diverse sexualities and gender identities in Madrid participated in a feminist community-based project, which supported them through the first wave of the pandemic. Facilitated by professionals, the project offered online meetings twice a month, helping them to articulate their needs and promote their agency over their choices and experiences. Based on their demands, participants chose the topics they wanted to discuss, proposed activities, and were the center of the program, while facilitators set up and maintained the online space, helping with participation and access to information and resources. Through this transformative experience, the members of the group developed friendship networks and started their activism, making public appearances in video campaigns and mainstream newspapers to make their needs visible to peers, families, social workers, policy makers, and nongovernmental organizations (NGOs). This research is part of a larger project that tackles the psychosocial factors that affected Spanish people with sexual and gender diversity during the first wave of the pandemic.

The Adaptation and Validation of the Trans Attitudes and Beliefs Scale to the Spanish Context.

This article examines the reliability and validity of the adaptation of the Trans Attitudes and Beliefs Scale (TABS), an instrument capable of detecting transphobic positions, to the Spanish context. A total of 829 psychology students participated in the adaptation procedure. A confirmatory factor analysis was performed to study the fit of the new scale to the factor structure of the original scale (interpersonal comfort, gender identity beliefs, and human value). Convergent validity evidence showed significant correlations and predictive levels with different constructs and sociodemographic variables. The internal consistency of the mean scores was adequate at the global level. The study showed that the TABS is a psychometrically sound instrument for the assessment of attitudes toward trans people, particularly in the context of debates over access to rights and the lack of professional training in disciplines such as psychology.

Genomics and transcriptomics insights into luteolin effects on the beta-rhizobial strain Cupriavidus necator UYPR2.512.

Cupriavidus necator UYPR2.512 is a rhizobial strain that belongs to the Beta-subclass of proteobacteria, able to establish successful symbiosis with Mimosoid legumes. The initial steps of rhizobium-legumes symbioses involve the reciprocal recognition by chemical signals, being luteolin one of the molecules involved. However, there is a lack of information on the effect of luteolin in beta-rhizobia. In this work, we used long-read sequencing to complete the genome of UYPR2.512 providing evidence for the existence of four closed circular replicons. We used an RNA-Seq approach to analyse the response of UYPR2.512 to luteolin. One hundred and forty-five genes were differentially expressed, with similar numbers of downregulated and upregulated genes. Most repressed genes were mapped to the main chromosome, while the upregulated genes were overrepresented among pCne512e, containing the symbiotic genes. Induced genes included the nod operon and genes implicated in exopolysaccharides and flagellar biosynthesis. We identified many genes involved in iron, copper and other heavy metals metabolism. Among repressed genes, we identified genes involved in basal carbon and nitrogen metabolism. Our results suggest that in response to luteolin, C. necator strain UYPR2.512 reshapes its metabolism in order to be prepared for the forthcoming symbiotic interaction.

Relevance of iron metabolic genes in biofilm and infection in uropathogenic Proteus mirabilis.

The microorganisms are found in the environment, forming sessile communities embedded in an extracellular matrix of their own production, called biofilm. These communities have a great relevance in the clinical context, since they are associated with infections caused by biofilm in medical implants, such as urinary catheters. The development of biofilms is a complex process where a great diversity of genes participate. The present work is based on the study of genes related to iron metabolism and its implication in the development of P. mirabilis biofilms and pathogenicity. For this study, two mutant strains defective in biofilm formation were selected, generated by the interruption of genes that encoded non-heme ferritin and TonB-dependent receptor. The mutations influence on the development of the biofilm was evaluated by different approaches. The complexity of the biofilm was analyzed using Confocal Laser Microscopy and image analysis. The mutants infectivity potential was assessed in two experimental mice models of urinary tract infection. The results obtained in the present work show us the role of the ferritin and a TonB-associated porin protein over the initial and later stages of biofilm development. Moreover, in the ascending UTI mouse model, both mutants failed to colonize the urinary tract. In CAUTI models, ferritin mutant damaged the bladder similarly to wild type but the Ton-B mutant was unable to generate infection in the urinary tract. The results obtained in the present work confirm the relevant role that iron metabolism genes have in P. mirabilis biofilm development and for infection in the urinary tract.

Building coalitions: The interconnections between feminism and trans* activism in Spain.

What made current Spanish feminism shift toward transfeminism? Based on in-depth interviews and literature reviews, we explore what factors facilitated the participation of trans* women in Spanish feminism. Tracing the history through relevant events such as the National Feminist Conferences, it becomes clear that trans* women participated in the 1993, 2000, and 2009 conferences, posing relevant issues regarding prostitution, transgenderism, and the political subject of feminism. Our research allows a break with global oppositional narratives, in which these movements are in conflict, and highlights the importance of understanding the vernacular nuances that take place in a particular geopolitical context.

Persistencia de síntomas en el postoperatorio de la colecistectomía laparoscópica por colelitiasis sintomática / Persistence of symptoms in the postoperative period after laparoscopic cholecystectomy for symptomatic cholelithiasis

Introducción. En la colelitiasis sintomática, el objetivo de la colecistectomía laparoscópica es aliviar su sintomatología. No obstante, un tercio de los pacientes continuarán con síntomas al año de la intervención. Presentamos un estudio prospectivo para determinar qué síntomas preoperatorios son predictivos de un mal resultado postoperatorio. Pacientes y método. Un total de 300 pacientes diagnosticados de colelitiasis han contestado, preoperatoriamente y al año de la operación, a un cuestionario donde estaban reflejados los síntomas atribuidos a la colelitiasis. Resultados. El 26 por ciento de los enfermos continuaban con sintomatología al año de la intervención. La pirosis, el dolor constante de localización imprecisa en hemiabdomen superior, la distensión abdominal pospandrial y las regurgitaciones fueron síntomas dispépticos con un valor estadístico significativo de mal resultado operatorio. Conclusión. La indicación para la realización de una colecistectomía laparoscópica continúa sin estar bien definida. Los enfermos con predominio preoperatorio de síntomas dispépticos, especialmente la pirosis, son predictivos de un mal resultado postoperatorio (AU)

Hemorragia digestiva secundaria a un leiomiosarcoma de íleon: tratamiento laparoscópico / Digestive hemorrhage secondary to leiomyosarcoma of the ileum: laparoscopic management

Las neoplasias malignas del intestino delgado representan únicamente el 2 por ciento de los tumores gastrointestinales. En su mayoría corresponden a adenocarcinomas y tumores carcinoides. Los tumores originados en la musculatura lisa intestinal se engloban dentro de la denominación de tumores estromales. Predominantemente se localizan en yeyuno e íleon. El tratamiento de esta entidad sigue siendo fundamentalmente quirúrgico, aunque su tratamiento laparoscópico sólo ha sido comunicado de forma ocasional. Describimos un caso de leiomiosarcoma de íleon cuyo tratamiento quirúrgico consistió en una resección laparoscópica (AU)

Linfangioma quístico de mama / Cystic lymphangioma of the breast

El linfangioma quístico de mama es un tumor benigno infrecuente del sistema linfático, del que únicamente han sido descritos 6 casos en la literatura médica mundial. Presentamos un caso diagnosticado preoperatoriamente por métodos radiológicos, y confirmado histológicamente (AU)

Las interleucinas 6, 8 y 10 en la fase inicial de la pancreatitis aguda. Su utilidad pronóstica / Interleukins 6, 8 and 10 in the initial phase of acute pancreatitis. Their prognostic utility

Introducción. La pancreatitis aguda es una grave enfermedad que precisa para la instauración de un tratamiento acorde con la gravedad, de un diagnóstico evolutivo precoz. El objetivo de nuestro estudio ha sido determinar los valores de interleucina 6, 8 y 10 en la fase inicial de la enfermedad. Pacientes y método. Hemos realizado un estudio prospectivo de 29 pacientes agrupados en pancreatitis leve, de mediana gravedad o grave. Las determinaciones de interleucinas en sangre venosa se realizaron en los primeros 5 días de evolución, y la cuantificación se efectuó con técnicas de enzimoinmunoanálisis. Resultados. En la pancreatitis grave existió una elevación de las tres interleucinas, con un pico máximo a las 36 h del inicio de la enfermedad. Desde el segundo día, el descenso de valores fue continuado. A partir del tercer día, las interleucinas 8 y 10 se normalizaron, persistiendo las diferencias estadísticamente significativas en los valores de la interleucina 6. Conclusiones. La interleucina 6 es el marcador que con mayor fiabilidad nos permitirá predecir, desde el día de admisión del paciente, la evolución pronóstica de la pancreatitis (AU)

Colecistitis aguda litiásica asociada a brucella melitensis. Presentación de un caso y revisión de la bibliografía / Acute lithiasic cholecystitis associated with Brucella melitensis. Case report and review of the literature

Aportamos el segundo caso de colecistitis aguda litiásica durante el curso de una brucelosis sistémica, según la revisión de la bibliografía mundial. Se describe su semiología clínica y tratamiento. Se resalta la importancia de considerar dicha enfermedad, como concomitante a otras, en zonas geográficas consideradas endémicas para la brucelosis (AU)

Primary colorectal lymphoma.

OBJECT: To analyze our experience in the treatment of primary colorectal lymphomas. PATIENTS: During the recent period from 1989 to 1995, a total number of 406 cases of malignant neoplasms of large intestine were treated at Department of Surgery, Hospital del S.A.S de Jerez de la Frontera. There were 5 cases of primary colorectal Non-Hodgkin's lymphomas, constituting 1.2% of all colorectal malignancies. METHODS: Medical records of all five patients were carefully reviewed. Surgical pathology specimens were retrospectively reexamined to confirm the diagnosis, and immunohistochemistry staining methods were performed. Dawson, Cornes and Morson criteria were used to distinguish primary colonic lymphoma. For tumor staging, a modification of the Ann-Arbor system for gastrointestinal lymphoma proposed by Musshoff and Schmidt-Vollmer was used. RESULTS: All cases were Non-Hodgkin's lymphomas. There were no cases of lymphoma of the rectum. There were 2 males and 3 females. Their ages ranged from 12 to 73 years, with an average age of 31 years. The cecum was the site of the lesions in 4 patients and the other was located in the sigmoid colon. Acute abdomen in three cases, undiagnosed abdominal mass in one and intussusception in the other one were the clinical presentation. Inmunohistochemical studies showed B-cell phenotype in 4 and non-B non-T Ki-1-positive phenotype in 1 patient. Chemotherapy was administered following resection in 100% of patients. CONCLUSIONS: Intraoperative diagnosis of lymphoma was not suspected in all cases but the malignancy was always present. The cecum is the commonest site of involvement. Both of our two patients presented with perforated lymphoma were associated with a poor short term prognosis. It is necessary to unify the staging system and the histologic classifications enabling a comparison of several studies.