[Pharmacological activity of the furfuryl amine salt of 4-chloro-N-(2-furylmethyl)-5-sulfamoyl anthranilic acid]. / Farmakologicheskaia aktivnost' furfurilaminovoi soli 4-khlor-N-(2-furilmetil)-5-sul'famoilantranilovoi kisloty.

Furfuryl amine salt of 4-chloro-N-(2-furylmethyl)-5-sulfamoyl anthranilic acid was shown to exert more pronounced diuretic and saluretic action in rats, mice and dogs than that of furosemide. The previous administration of furfuryl amine salt of furosemide promoted normalization of the excretory processes of the kidney and increased survival rate of rats in ischemia of the single kidney. The antiedema activity of the drug was found to be much more pronounced than that of furosemide.

[Determination of the specific activity and biological availability of Soviet-made furosemide]. / Opredelenie spetsificheskoi aktivnosti i biologicheskoi dostupnosti otechestvennogo furosemida.

Experiments on mice, rats and dogs showed that furosemide manufactured in the USSR is not inferior by its specific activity to furosemide manufactured abroad. Furosemide manufactured in the USSR and furosemide-substance made in Finland were compared at three doses--1, 5 and 25 mg/kg. The bioavailability of furosemide tablets manufactured in the USSR and that of "Polfa" production tablets studied on rats (5 and 25 mg/kg) and dogs (40 mg) appeared to be identical.