RESUMO
Colorectal cancer is closely related to changes in the immune status at all stages of the disease. The main method of treatment for colorectal cancer is surgery. Surgical intervention as any pathological impact on the body from the outside is leading to suppression of both humoral and cellular immunity. Melatonin can be used to stimulate the immune system acting as a protective agent. Currently melatonin is used in oncology practice rather modest - as part of a complex postoperative therapy. Melatonin in pharmaceutical concentrations acts as differentiation factor reducing infiltrative and metastatic potential by restoring the links between signaling molecules and inhibiting existing cell-cell contacts, which can be used in the preoperative therapy.
Assuntos
Neoplasias Colorretais/tratamento farmacológico , Neoplasias Colorretais/cirurgia , Imunidade Celular/efeitos dos fármacos , Melatonina/uso terapêutico , Neoplasias Colorretais/genética , Neoplasias Colorretais/imunologia , Humanos , Melatonina/imunologia , Metástase Neoplásica , Transdução de Sinais/efeitos dos fármacosRESUMO
It was shown by the authors that changes of the level of cytokines reflected the degree of invasiveness of operative intervention. The endovideosurgical approach was less traumatic and provided a rapid rehabilitation of the patients in postoperative period. It is possible to consider the high levels of IL-10 as a predictor of development of local inflammatory process and as an indicator of probable infectious complications in postoperative period.
Assuntos
Colectomia , Neoplasias Colorretais , Inflamação/imunologia , Laparotomia , Complicações Pós-Operatórias/imunologia , Idoso , Idoso de 80 Anos ou mais , Colectomia/efeitos adversos , Colectomia/métodos , Neoplasias Colorretais/imunologia , Neoplasias Colorretais/cirurgia , Feminino , Humanos , Interleucina-10/sangue , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Monitorização Imunológica/métodos , Peristaltismo/imunologia , Estatística como AssuntoAssuntos
Melatonina , Complicações Pós-Operatórias , Procedimentos Cirúrgicos Operatórios/efeitos adversos , Antioxidantes/metabolismo , Antioxidantes/farmacologia , Humanos , Melatonina/metabolismo , Melatonina/farmacologia , Complicações Pós-Operatórias/metabolismo , Complicações Pós-Operatórias/prevenção & controle , Estresse Fisiológico/efeitos dos fármacosRESUMO
Melatonin is neurohormone, which is involved in regulation of many functions of an organism, including the digestive system. Therefore the authors offered to include this hormone as a preconditioner factor in surgical treatment of colon tumors using laparotomy and laparoscopy. Preoperative application of melatonin allowed shortening the terms of postoperative period and hospital stay.
