Assuntos
Neoplasias da Mama/patologia , Leucemia Linfoide/patologia , Leucemia Mieloide Aguda/patologia , Linfoma não Hodgkin/secundário , Melanoma/secundário , Neoplasias Meníngeas/secundário , Neoplasias Cutâneas/patologia , Terapia Combinada , Seguimentos , Humanos , Linfoma não Hodgkin/patologia , Melanoma/patologia , Neoplasias Meníngeas/patologia , Neoplasias Meníngeas/terapia , Meninges/patologia , Metotrexato/administração & dosagemRESUMO
According to the clinical classification of amyotrophic lateral sclerosis by Hemmer its "hemiplegic type" is described from two observations in 37 personal cases. The peculiar difficulties of differential diagnosis especially with the hemiplegic type of multiple sclerosis in two further cases are discussed in detail. Four cases of "Mills' syndrome" are compared. "Mills' syndrome" has been assumed to be a slowly progressive, unilateral ascending or descending variant of amyotrophic lateral sclerosis. A study of Mills' original papers and evaluation of personal observations leads to a more critical assessment. In Mills' original cases, widely different entities such as multiple sclerosis, syphilis, and parkinsonism are included besides amyotrophic lateral sclerosis. In the light of the investigations presented here, Mills' syndrome seems to be merely an obsolete clinical term.
Assuntos
Esclerose Lateral Amiotrófica/diagnóstico , Hemiplegia/diagnóstico , Adulto , Idoso , Paralisia Bulbar Progressiva/diagnóstico , Eletromiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Esclerose Múltipla/diagnóstico , SíndromeRESUMO
Sequelae of sural nerve biopsy were examined in 24 patients. Fourteen subjects reported persisting pain or dysaesthesias for more than one year. In nine patients the symptoms were mild, in five severe. Hypaesthesia of the lateral aspect of the foot was found in 17 out of 18 patients with otherwise normal or only slightly impaired sensory function. In one patient sural nerve biopsy did not cause permanent sensory loss. Pain and dysaesthesia were not significantly related to post-biopsy or generalized hypaesthesia.
Assuntos
Biópsia/efeitos adversos , Nervos Espinhais/cirurgia , Nervo Sural/cirurgia , Adolescente , Adulto , Criança , Feminino , Seguimentos , Humanos , Hipestesia/etiologia , Masculino , Doenças do Sistema Nervoso/etiologia , Neuroma/etiologia , Dor/etiologia , Neoplasias do Sistema Nervoso Periférico/etiologia , SensaçãoRESUMO
A 35-year-old woman developed neurological signs over several weeks after a symptom-free rubella infection. Rubella encephalitis was diagnosed from a significant rise in rubella virus antibodies and the demonstration of IgM antibodies. Slow improvement in the neurological defects began not earlier than in the 16th week of illness. Severe defects of speaking, reading, writing and calculating as well as mild disorders of affect still persisted eight months after onset of the illness.
