[Changes of the thyroid hormone status in children with cerebral palsy and other neurological pathology].

Content of thyroid hormones (T3 and T4) and thyrotropin (TTG) hormone in blood plasma has been studied in 142 children with neurological pathology (cerebral palsy, perinatal CNS lesion). In most cases, there was a significant increase of T3 and T4 and reduction of TTG as compared to control group of healthy children. The changes of thyroid hormones content depended on the patient's age and severity of a pathological condition. A mother pregnancy course impacted on the hormones level. The content of T3 and T4 in blood plasma was higher in case of cystitis in mother's anamnesis or a persistent threat of preterm delivery. In patients, a TTG reduction correlated with mental retardation. In those with marked dysplasia of osseous tissue (osteoclast, osteopathy), the TTG content was higher comparing to patients without such malformations.

[Biochemical changes of red blood cells in children with cerebral palsy and other organic brain disorders].

One hundred and twenty-five children with cerebral palsy (n = 108) and organic CNS lesions (n = 17) have been studied. A control group included 30 children without any neurological lesions. Lipids and phospholipids spectra, Ca, Mg- and Na, K-ATPases, intensity of red blood cells lipid peroxidation and erythrocyte free magnesium content have been determined. Children with cerebral palsy had a higher percentage of cholesterol ethers and final products of lipid peroxidation in red blood cells--Shiff bases and a decrease of intraerythrocytic free magnesium. Patients with atonic-astatic syndrome were characterized by a sharp increase of Na, K-ATPase activity accompanied by increased content of such phospholipids as cardiolipin and phosphatide acid as well as Shiff bases. In patients with organic CNS lesions, Shiff bases content was similar to that in the control group, intracellular magnesium also did not differ significantly from the controls, but cardiolipin, phosphatide acid, cholesterol ethers and triglycerol concentrations were reduced. All the patients with neurological disorders had an increased percentage of phosphatidilcholin in red blood cells.

[Lipid peroxidation in neurological pathology in children].

The intensity of lipid peroxidation (LPO) was studied by the content of the listed below in erythrocytes of children with neurological pathology: diene conjugates, trienketones and LPO products. Intensified LPO processes were registered in children with neurology and primarily in those with cerebral spastic infantile paralysis (CSIP). The detected changes in the LPO products of erythrocyte membranes depended on a disease variation on an intellectual development of sick child. The LPO activation affects possibly the development (lesion) of craniocerebral innervation in patients. Changed LPO parameters were found in examined sick children to be most closely related with the development of their motor skills and with the formation of the bone-muscle system, thus, an essentially higher content of LPO products was registered in erythrocytes of children with a reduced muscular activity (in those not capable of sitting, standing or walking). Considering the above stated and with respect to the deficit of Vitamin E registered in such patients, children with CSIP or with impending CSIP need, obviously a prolonged membrane-stabilizing therapy by antioxidants and essential phospholipids including traps of radicals, which should cut the number of children with severe CSIP and with residual perinatal lesions of the central nervous system.

[Red cell phospholipid composition in children with neurological pathology]. / Fosfolipidnyi sostav érotrotsitov pri nevrologicheskoi patologii u detei.

Changes of red cell membrane phospholipid composition were studied in children with different neurological disorders--cerebral palsy, organic CNS damages and perinatal encephalopathy. The percentages of phosphatidylcholin and, in some cases, of phosphoglycerides increase depending on the disease type. The above changes were determined by craniocerebral innervation disturbances and concerned mainly the content of phosphatidylcholin, phosphatidylserine and phosphatidylethanolamin. The determination analysis established that the changes of erythrocytes phospholipid content correlated with clinical state severity and intellectual development of children, and to depend on the disease type and may affect directly development/disturbance of craniocerebral innervation and intellectual development. The age changes were shown to influence phosphatid acid percentage in the patients.