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J Pept Sci ; 18(9): 556-9, 2012 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-22786725

RESUMO

ß-Amino acids containing α,ß-hybrid peptides show great potential as peptidomimetics. In this paper, we describe the synthesis and affinity to µ-opioid and δ-opioid receptors of α,ß-hybrids, analogs of the tetrapeptide Tyr- d-Ala-Phe-Phe-NH(2) (TAPP). Each amino acid was replaced with an l- or d-ß(3) -h-amino acid. All α,ß-hybrids of TAPP analogs were synthesized in solution and tested for affinity to µ-opioid and δ-opioid receptors. The analog Tyr-ß(3) h- d-Ala-Phe-PheNH(2) was found to be as active as the native tetrapeptide.


Assuntos
Aminoácidos/química , Oligopeptídeos/química , Peptídeos Opioides/síntese química , Peptídeos Opioides/metabolismo , Receptores Opioides/metabolismo , Peptídeos Opioides/química , Ligação Proteica
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