The Health Impact Fund: how might it work for novel anticoagulants in atrial fibrillation?

Cardiovascular diseases represent the greatest burden of global disease. Spending on cardiovascular diseases is higher than for other diseases, with the majority being spent on drugs. Therefore, these drugs and these diseases are hugely important to health systems, society, and pharmaceutical companies. The Health Impact Fund represents a new mechanism by which pharmaceutical innovators would be rewarded on the basis of the health impact of their new drugs. This review illustrates the concept of the Health Impact Fund using the example of novel anticoagulants for prevention of stroke and thromboembolism in atrial fibrillation. By considering existing data and the current situation for novel anticoagulants, we suggest that epidemiologic data and modeling techniques can be used to predict future trends in disease and the health impact of new drugs. The Health Impact Fund may offer potential benefits to pharmaceutical companies, patients, and governments and warrants proper investigation.

The Health Impact Fund: a potential solution to inequity in global drug access.

Global health inequities persist despite significant increases in funding and a growing number of global health initiatives. Especially vulnerable to disease, the poor majority of the world's population currently cannot afford advanced medicines, and the diseases confined to the poor receive little attention from pharmaceutical research. As a complement to the existing intellectual property regime, we have proposed the Health Impact Fund (HIF) as a mechanism that would create incentives for the development and optimal promotion of new high-impact medicines sold at the cost of manufacture. In this article, we outline the HIF and its ethical significance.

Para erradicar a pobreza sistêmica: em defesa de um Dividendo dos Recursos Globais / Propuesta para un Dividendo sobre Recursos Globales / Eradicating systemic poverty: brief for a Global Resources Dividend

A atual apropriação da riqueza de nosso planeta é muito desigual. As classes economicamente favorecidas utilizam muitíssimo mais os recursos mundiais, e o fazem de forma unilateral, sem dar qualquer compensação às classes menos favorecidas por seu consumo desproporcional. Invocando três diferentes razões da injustiça - o efeito das instituições sociais compartilhadas, a exclusão não compensada do uso dos recursos naturais e os efeitos de uma história comum e violenta , o objetivo do autor é mostrar que talvez seja possível reunir partidários de correntes dominantes do pensamento político normativo ocidental numa coalizão voltada para a erradicação da pobreza mundial mediante a introdução de um Dividendo dos Recursos Globais, ou DRG. Uma versão anterior deste artigo foi publicada pela Revista Lua Nova: Thomas Pogge. "Uma proposta de reforma: um dividendo global de recursos", Revista Lua Nova n. 34, 1994. Agradecemos à Revista Lua Nova pela autorização da reimpressão deste artigo.

The current appropriation of wealth from our planet is highly uneven. Affluent people use vastly more of the world's resources, and they do so unilaterally, without giving any compensation to the global poor for their disproportionate consumption. Invoking three different grounds of injustice - the effects of shared social institutions, the uncompensated exclusion from the use of natural resources, and the effects of a common and violent history - the author's goal is to show that it may be possible to gather adherents of the dominant strands of Western normative political thought into a coalition focused on eradicating world poverty through the introduction of a Global Resources Dividend or GRD. A previous version of Thomas Pogge, "Eradicating Systemic Poverty: brief for a global resources dividend", was published in the Journal of Human Development (Volume 2, Number 1/January 1, 2001, pages 59-77, published by Routledge, part of the Taylor & Francis Group). The Sur Journal would like to thank Taylor & Francis Ltd. for the permission to reprint this article (permission's reference number: MW/CJHD/N503).

La actual apropiación de la riqueza de nuestro planeta es enormemente desigual. Las clases económicamente más favorecidas emplean una cantidad increíblemente mayor de los recursos mundiales, y lo realizan de un modo unilateral, sin otorgar ningún tipo de compensación a las clases menos favorecidas por esta desproporción en el consumo. Apelando a tres diferentes criterios de injusticia -, los efectos de instituciones sociales compartidas, la exclusión no-compensada del uso de recursos naturales y los efectos de una historia común violenta -el objetivo del autor es mostrar que es posible sumar adhesiones de las corrientes dominantes del pensamiento político normativo occidental para una coalición centrada en la erradicación de la pobreza global a través de la introducción de un Dividendo sobre los Recursos Globales o DRG. Una version previa de Thomas Pogge, "Eradicating Systemic Poverty: brief for a global resources dividend" fue publicada en inglés en el Journal of Human Development (v. 2, Número 1/Enero 1, 2001, páginas 59-77, publicado por Routledge, integrante de Taylor & Francis Group). La Revista Sur agradece a Taylor & Francis Ltd. la autorización para reimprimir este artículo (número de la autorización: MW/CJHD/N503).