RESUMO
In order to determine individual sensitivity, 0.4 microgram/kg/min of fenoterol was in fused to 95 pregnant women prior to institution of tocolytic treatment against premature delivery. Changes of maternal heart rate during this test was recorded and analysed retrospectively. The following conclusions were drawn: Even in a carefully prescreened pregnant population, 4.2% of gravidas proved to be hypersensitive to fenoterol: the irreversible commencement of premature delivery was accompanied by a significant decrease of beta sensitivity: to avoid complications due to tocolytic therapy, it is necessary to stop sympathomimetic medication in a stepwise manner: there was no pathologic consequences of fenoterol treatment to the newborn babies.
Assuntos
Agonistas Adrenérgicos beta/uso terapêutico , Etanolaminas/uso terapêutico , Fenoterol/uso terapêutico , Trabalho de Parto Prematuro/prevenção & controle , Peso ao Nascer , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Gravidez , Progesterona/sangueAssuntos
Aborto Espontâneo , Peso ao Nascer , Feminino , Humanos , Hungria , Masculino , Idade Materna , Paridade , Gravidez , Estatística como AssuntoAssuntos
Aborto Espontâneo , Trabalho de Parto Prematuro/epidemiologia , Gravidez , Aborto Habitual/epidemiologia , Aborto Induzido/efeitos adversos , Coeficiente de Natalidade , Feminino , Idade Gestacional , Humanos , Hungria , Mortalidade Infantil , Recém-Nascido , Recém-Nascido Prematuro , Complicações do Trabalho de Parto/epidemiologia , Complicações na Gravidez/epidemiologia , Estatística como AssuntoRESUMO
Plasma oestradiol 17beta and progesterone levels in 11 patients admitted to hospital for threatened premature labour of unknown aetiology were compared with those of women at similar stages of gestation whose pregnancy was normal. Oestradiol levels in the study group were slightly higher than in the normal controls but their progesterone levels were significantly lower. This progesterone deficiency increased the oestradiol/progesterone ratio in the study group patients, and it increased still more as the progesterone withdrawal continued during premature labour.Since uterine activity during pregnancy is regulated by a balanced action of several factors a deficiency in progesterone, an opponent of uterine activity, creates a regulatory imbalance which, if uncorrected, provokes premature labour. An increase in uterine volume stimulates uterine activity, and the present study reinforced our previous conclusion that the uterine-volume/plasma-progesterone ratio is a more accurate measure of the state of regulatory balance than the progesterone level alone.The cause of the progesterone deficiency in these cases remains unexplained, but we suggest that placental growth and function are contributory factors. We are investigating ways of correcting the resulting imbalance in the regulatory mechanism.
