[Tianeptine, an uncommon psychotropic drug]. / La tianeptine, un psychotrope original.

The pharmacological studies show that tianeptine (Stablon) is an original psychotropic drug. In classical and behavioural pharmacology, tianeptine has a novel antidepressant profile, different from other molecules and an anxiolytic effect but different from the benzodiazepines. Tianeptine does not cause sedation and sleeping troubles. In mice, tianeptine does not impair spatial memory but have facilitating effects on both working and reference memory. Tianeptine also increased the focalization of attention in cat and is active on comportmental adaptation models in stress. The electrophysiological data showed that tianeptine increases activity of the hippocampus pyramidal cells and decreases the recovery time after inhibitory substances application. Neurobiochemical studies showed that tianeptine increases serotonin uptake, in rat brain and in rat and human platelets, after acute and chronic treatment. Neuroendocrinology data showed that tianeptine decreases CRF and ACTH levels. Current research on the effect of tianeptine on acetylcholine could explain its anti-stress and memory facilitation activity.

Dislocations in spinel and garnet high-pressure polymorphs of olivine and pyroxene: implications for mantle rheology.

The meteorite Tenham was observed by transmission electron microscopy and ringwoodite and majorite, the high-pressure polymorphs of olivine and pyroxene, were identified. Ringwoodite contains antiphase boundaries and straight dislocations that are probably dissociated. Mantle flow of spinel might proceed by pure climb, and whole-mantle convection may be possible if the grain size is small enough.