Results and follow-up after percutaneous pulsed laser-assisted balloon angioplasty guided by spectroscopy.

BACKGROUND: Few data are available on the long-term outcome of patients who undergo laser-assisted balloon angioplasty for recanalization of occluded peripheral arteries. Because the cost of laser angioplasty is high, the value of the method should be carefully analyzed before it can be considered a routine method for recanalization. The purpose of this study was to evaluate the early and late results of laser-assisted balloon angioplasty in patients who could not be recanalized by conventional techniques. METHODS AND RESULTS: Laser angioplasty was performed in 66 patients with total occlusion of the iliofemoral artery in whom mechanical techniques failed to recanalize the obstructed vessel. The system consisted of a pulsed dye laser operated at 480 nm, 2 microseconds/pulse, 5 Hz, 50 mJ/pulse coupled into a 0.021-in. laser catheter. The treatment laser was connected with a diagnostic laser to induce tissue fluorescence for spectroscopic analysis via the same fiber. The treatment laser was emitted only when atheromatous tissue was recognized. After a pilot hole was created by laser emission, dilatation was performed to enlarge the channel. The mean length of occlusion was 8.8 +/- 6.1 cm. The primary success rate was 82%. It did not depend on the length of occlusion but was greater in non-calcified than in calcified lesions (88% versus 71%, p less than 0.03). Complications included seven early reocclusions that could be recanalized and eight perforations without clinical sequelae. At a mean 18-month follow-up, 64% of the laser-treated arteries remained patent. The rate of patency was related neither to the length of the occlusion nor to calcifications but was lower in patients who had early reocclusion (p less than 0.02). CONCLUSIONS: Pulsed dye laser-assisted balloon angioplasty is effective for recanalization of totally occluded arteries that cannot be treated by conventional means. The efficacy is limited by calcifications. The long-term patency rate is acceptable given the severity of the lesions.

Longitudinal study of various transport abnormalities as an index of severity in children and adolescents suffering from essential hypertension.

Erythrocyte cation fluxes were measured in fresh cells, on two different occasions, in 90 children and adolescents suffering from essential hypertension who were followed for a prolonged period. The purpose of the present study was to track the stability of erythrocyte cation fluxes with time, and to determine whether a known sodium transport abnormality can predict the severity of essential hypertension. The patients with an increased Na-Li countertransport were the most severely hypertensive in three different ways. Clinically, they presented a stable rather than a labile form of hypertension. Hemodynamically, the mean arterial pressure was higher than that of the other subgroups. Finally, in those children followed for more than 2 years, this subgroup remained hypertensive with time. The patients with a decreased Na,K cotransport activity were second in severity; however, blood pressure was often labile, mean arterial pressure was slightly lower than that of the previous subgroup and all patients remained hypertensive with time but in four out of six patients the hypertension was labile. The patients with increased passive sodium permeability presented a mild form of hypertension. The patients with normal erythrocyte cation fluxes seemed to form a heterogeneous group. A few were severely hypertensive, but in most the hypertension was borderline and transient. We conclude that determination of erythrocyte cation fluxes may be reproducible, and may be a useful index of the severity of essential hypertension in children and adolescents.

Orion, an improved balloon on a wire system: initial experience.

The Orion coronary angioplasty improved balloon on a wire system was used in 42 patients (53 stenoses) including 5 patients with acute myocardial infarction, 18 patients with unstable angina, and 4 patients with kissing balloon angioplasty via a single guiding catheter. All stenoses were crossed successfully and the immediate and in-hospital success rates were 98 and 93%, respectively. The simple construction, low profile, and improved steerability allowed successful and quick angioplasty of high grade stenotic lesions. This balloon catheter represents a significant advance in angioplasty technology.

[Percutaneous angioplasty using spectroscopy-guided pulsed laser]. / Angioplastie percutanée par laser pulsé guidé par spectroscopie.

Percutaneous laser angioplasty was performed in 19 patients with calcified and non-calcified occlusions (4-25 cm long) of the superficial femoral artery, using a pulsed dye laser at 480 nm and a pulse duration of 2 microseconds per pulse. The treatment laser was guided by a 325 nm diagnostic laser that induced tissue fluorescence. The laser system operated through a single 200 microns optical fiber. Computer spectral analysis of the tissue fluorescence located at the distal end of the fiber tip directed emission of the treatment laser only at the atheroma without affecting the arterial wall. A successful primary laser recanalization was obtained in all cases and was followed by balloon dilation in all but one patient. One mechanical perforation and 2 mechanical arterial dissections by the fiber, and 1 perforation and 1 dissection by the guide wire occurred, but no complications due to the treatment or diagnostic laser were observed. The safety of the procedure seemed to be enhanced by the spectroscopic guidance system which enabled plaque recognition. The pulsed dye treatment laser was well tolerated and effective even in heavily calcified arteries.

[Myocardial protection by coronary autotransfusion during angioplasty]. / Protection myocardique par autotransfusion coronaire au cours de l'angioplastie.

Coronary autologous blood perfusion may protect the myocardium against ischemia during arterial occlusion due to balloon inflation. During balloon inflation, arterial blood was perfused via the balloon catheter in 19 patients with single proximal severe left anterior descending artery stenosis and normal left ventricular function. Blood was perfused using a contrast medium injector at a flow rate of 40 ml/min. The balloon was maintained inflated for 60 seconds at 6 atmospheres. Two inflations were performed with perfusion and 2 without. Myocardial ischemia was assessed by ST elevations on both the peripheral and intracoronary ECGs, changes in left ventricular systolic and end diastolic pressures and peak positive and negative dP/dt. A positive response was obtained in 11 patients. In 5 patients, the myocardial ischemia induced by dilatation was not alleviated by the perfusion and in 3 patients ischemia was increased by perfusion. In conclusion, ischemia is inconsistently reduced by autologous blood perfusion and its adverse effect in some patients could limit its use.

The inferior alveolar artery in its bony course.

Based on the dissection of 30 hemi-mandibles, the authors report a study of the inferior alveolar artery in its intraosseous course. On morphologic considerations they propose a classification of the collaterals into two groups: the principal collaterals destined for the teeth and the bony alveolar tissue and the secondary collaterals destined for the sheath and the nerve as well as the bony tissue around the canal. Loss of the teeth and absorption of the alveolar bone modify the caliber of the inferior alveolar arterial axis, the distribution of its collaterals and possibly its mode of termination. These facts suggest a consideration of the vascularization of the mandible in terms of four sectors. They arrive at practical conclusions that may be drawn from this study in stomatology.

[Traumatic tricuspid insufficiency. Review of the literature, apropos of a case]. / Insuffisance tricuspidienne traumatique. Revue de la littérature, à propos d'un cas.

The authors report a case of traumatic tricuspid incompetence due to rupture of an anterior pillar and the chordae, associated with pericardial rupture, a first degree atrioventricular block, a persistent complete right bundle branch block and acute recurrent pericarditis. The diagnosis, suggested by echocardiography was confirmed by right cardiac catheterisation. The patient underwent tricuspid plasty six months after the accident. On the basis of a review of the literature, the authors discuss traumatic tricuspid incompetence (its symptoms and associated lesions), the diagnostic methods and the therapeutic approach.

[Cardiac manifestations of Lyme disease. Apropos of 2 cases]. / Les manifestations cardiaques de la maladie de Lyme. A propos de deux observations.

Lyme disease, a well-known entity in the United States, has featured only rarely in the French literature. We report two cases from the Cardiology Department with acute symptomatic atrio-ventricular block. The illness begins with migratory chronic erythema, which is the best marker of the condition. This is followed by neurological, joint and cardiac manifestations. Cardiac involvement consists essentially in A-V block of varying severity, which rapidly regresses. Until the recent discovery of the arthropod vector responsible (Ixodes dammini), the diagnosis was clinical and was confirmed by negative serological results for the other infectious agents. Penicillin and tetracycline are effective at the skin lesion stage. It is important to recognise this condition since there is no case of complete A-V block lasting longer than 2 weeks.