[Possibility of the pharmacologic treatment of post-ischemic myocardial damage]. / Vozmozhnost' farmakologicheskogo vozdeistviia na postishemicheskoe povrezhdenie miokarda.

The influence of ethacizin and nonachlazin on the size of myocardial necrosis, caused by 1.5-hour partial occlusion of the coronary artery was studied in conscious rabbits. The drugs were administered for 3 days, after the blood supply in the ischemic zones had been recovered. Ethacizin had a more pronounced effect, as compared to nonachlazin. The data obtained suggest that in the case of isochemic heart disease pharmacotherapy can be used not only for the prevention and arrest of anginal attacks, but also for the treatment of postischemic cardiac lesions.

Comprehensive assessment of the effectiveness of nitrates with prolonged action in patients with acute myocardial infarction.

In 64 patients with extensive acute myocardial infarction, the effect of the Sustak-forte preparation (nitroglycerin with prolonged action) on central and peripheral haemodynamics and the size of the periinfarction zone was studied. A diminution of the extent of the periinfarction zone was found on the 3rd day of the disease (according to the results of precordial ECG mapping and enzymologic examinations). Analysis of the findings in 476 patients with AMI, using the method of retrospective randomization, documented a statistically significantly better effect of treatment in patients who were given nitrates than in those not receiving them.