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1.
Contemp Clin Trials ; 107: 106480, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34126263

RESUMO

BACKGROUND: Exposure to ultraviolet radiation (UVR) is the major modifiable risk factor for skin cancers. The majority of lifetime UVR exposure occurs before age 20, underscoring an important window for risk reduction. Incorporation of skills-based sunscreen education into school health curricula may foster the development of consistent and effective use of sunscreen among children and youth. We describe the study protocol for a first-of-its-kind study that examined the feasibility of bringing skills-based sunscreen education into kindergarten classrooms. METHODS: Participants were 96 kindergarten students across four classrooms in a single elementary school. A single-blind open-label trial design was used to evaluate the feasibility of incorporating a song-based, video-guided intervention for independent application of sunscreen into the kindergarten curriculum. Students first completed a 10-day no-intervention baseline period, followed by a 10-day intervention period, and then a 10-day randomized follow-up period where students were randomly assigned to continue with the intervention or to revert to the no-intervention condition. OUTCOMES: Feasibility metrics associated with study process, resources, management, scientific outcomes and safety were gathered. The primary outcome was pre-to-post intervention changes in student engagement in the sunscreen task. The secondary outcome was pre-to-post intervention changes in the proportion of exposed skin to which a student applies sunscreen. Teacher and student perceptions of intervention value and utility were also evaluated. DISCUSSION: This is the study protocol for a clinical trial designed to determine the feasibility of implementing a skills-based sunscreen curriculum in kindergarten classrooms. Next steps include evaluation of the intervention for efficacy and effectiveness. CLINICAL TRIAL REGISTRATION: NCT03752736.


Assuntos
Protetores Solares , Raios Ultravioleta , Pré-Escolar , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Instituições Acadêmicas , Método Simples-Cego , Estudantes , Raios Ultravioleta/efeitos adversos
2.
Cutis ; 81(1): 33-6, 2008 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-18306845

RESUMO

An 88-year-old man from the Dominican Republic with a history of gastric adenocarcinoma was admitted with one month of fatigue, anorexia, weight loss, and abdominal pain. The dermatology department was consulted to evaluate an asymptomatic, shiny, firm, red nodule on the lower left chest, with an expanding rim of erythema. Skin biopsies were performed from the nodule and surrounding rim of erythema, which were both diagnostic of peripheral T-cell lymphoma (PTCL). This case is a unique example of PTCL with erysipelaslike spread.


Assuntos
Linfoma de Células T Periférico/diagnóstico , Neoplasias Cutâneas/diagnóstico , Pele/patologia , Idoso de 80 Anos ou mais , Antígenos CD/análise , Diagnóstico Diferencial , Erisipela/diagnóstico , Evolução Fatal , Humanos , Imuno-Histoquímica , Imunofenotipagem , Masculino
4.
J Am Acad Dermatol ; 54(5 Suppl): S192-7, 2006 May.
Artigo em Inglês | MEDLINE | ID: mdl-16631938

RESUMO

Natural killer (NK)-cell neoplasms are relatively uncommon tumors. Classification schemes prior to that of the World Health Organization (2001) did not account clearly for these neoplasms. Advances in immunohematology over the past 10 years have aided in the recognition and categorization of NK-cell tumors. One type of tumor that belongs to this class is extranodal, nasal-type NK/T-cell lymphoma. These lymphoma cells express a cytotoxic T-cell or NK-cell phenotype, including CD56 and TIA-1. Nasal-type NK/T-cell lymphomas arise from extranasal sites such as the skin and are often associated with Epstein-Barr virus infection. Asian adults are affected most commonly. Very few pediatric cases are reported in the literature, of which only 5 presented with cutaneous involvement. We report a case of an adolescent Bangladeshi boy with extranodal, nasal-type NK/T-cell lymphoma who had cutaneous nodules on the extremities.


Assuntos
Extremidades , Células Matadoras Naturais/patologia , Linfoma de Células T/patologia , Neoplasias Cutâneas/patologia , Adolescente , Antígenos CD/análise , Bangladesh , Análise Citogenética , Evolução Fatal , Humanos , Linfócitos/imunologia , Linfoma de Células T/genética , Linfoma de Células T/imunologia , Masculino , Neoplasias Cutâneas/genética , Neoplasias Cutâneas/imunologia
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