[Primary controlled endolymphatic antibiotic therapy in traumatology and orthopedics]. / Priamaia upravlennaia éndolimfaticheskaia antibiotikoterapiia v travmatologii i ortopedii.

The work analyses 55 cases of traumatic osteomyelitis of the leg bones, open fractures of the leg bones, and medial fractures of the femoral neck. Patients with medial fractures of the neck of the femur were treated by endoprosthesis after Mur-Kaplan. Endolymphatic antibiotic therapy was included in the complex of therapeutic measures in each group of patients. This method allowed suppuration of the postoperative wounds to be avoided and promoted in this manner rehabilitation of the patients.

[Direct endolymphatic administration of antitubercular drugs in patients with inflammatory diseases of the urogenital organs]. / Priamoe éndolimfaticheskoe vvedenie antibakterial'nykh preparatov bol'nym s vospalitel'nymi zabolevaniiami mochepolovykh organov.

Direct endolymphatic administration of broad-spectrum antibiotics was used in treatment of approximately 21 patients with complicated urogenital tuberculosis. The duration of the endolymphatic therapy ranged from 3 to 13 days. In the patients treated with endolymphatic administration of the antibiotics the effects were favourable. The use of the procedure were shown expedient because marked lesions in the urinary tracts, frequent chronic renal failure and the microbial flora resistance to the drugs lowered the efficacy of the treatment with the routine administration of the drugs. The drugs used i.e. klaforan and gentamicin were approved by the USSR Pharmacological Committee. The drugs were administered with dosator NDL-3 in original modification which provided continuous polycollector endolymphatic antibiotic therapy with simultaneous lavage of the lymphatic channel. It was shown expedient to use endolymphatic administration of antibiotics in treatment of complicated urogenital tuberculosis alone or in combination with the preoperative procedures.

[Intralymphatic administration of antibiotics in the complex treatment of suppurative complications in patients with neurosurgical pathology]. / Endolimfaticheskoe vvedenie antibiotikov v kompleksnom lechenii gnoinykn oslozhnenii u bol'nykh s neirokhirurgicheskoi patologiei.

The efficacy of endolymphatic route of gentamicin and ceporin administration was studied in 89 patients with neurosurgical pathological processes complicated by acute pneumonia (80 patients) and meningoencephalitis (9 patients) usually after ineffective antibiotic therapy according to the routine methods. The antibiotics were used in accordance with the antibiograms of the causative agents isolated from the bronchial tree or CSF. The endolymphatic use of gentamicin or ceporin once a day in doses of 80 mg or 1 g respectively provided rapid sanation and arresting of the inflammatory foci, lowering of the intoxication level, more rapid promotion of the positive time course of the clinico-roentgenological and laboratory indices and decreasing of the recovery periods by 1.5-2 times in 86 per cent of the patients with pneumonia. The endolymphatic administration of gentamicin in a dose of 80 mg twice a day or ceporin in a dose of 1 g twice a day allowed one to maintain the antibiotic therapeutic levels in the cerebrospinal fluid and to obtain satisfactory clinical results in the combined treatment of meningoencephalitis. The endolymphatic administration of the drugs was well tolerated by the patients and no adverse reactions were observed. This route of administration of antibiotics and in particular broad spectrum antibiotics may be recommended for urgent antibacterial therapy of especially severe neurosurgical patients with pyo-inflammatory complications and patients who did not respond to the routine antibiotic therapy.

[Experience with the experimental autograft of a skin-fascia flap with simultaneous restoration of the blood circulation in the graft]. / Oyt éksperimental'noi autotransplantatsii kozhno-fastsial'nogo loskuta s odnomomentnym vosstanovleniem krovoobrashcheniia v transplantate.

The use of the microsurgery allows to carry out the autotransplantation of the skin-fascial graft. Optic magnification, special instruments and suture material are necessary for the formation of anastomoses of the small diameter arteries and veins. The autotransplantation of skin-fascial grafts permits to correct extensive defects of the skin and underlying tissues. A thorough formation of vascular anastomoses and an adequate pharmacotherapy are of great importance.