RESUMO
T-cell prolymphocytic leukemia (T-PLL) is the most common mature T-cell leukemia (MTCL). Cutaneous involvement is a characteristic symptom of T-PLL and appears in up to one-third of cases; however, T-PLL is a relatively unknown disease in the field of dermatology. In this article, we seek to increase awareness and educate physicians about the clinical manifestations of T-PLL. Hopefully, an increased awareness of this disease will lead to more prompt diagnoses and better prognoses for affected patients.
Assuntos
Leucemia Prolinfocítica de Células T/diagnóstico , Neoplasias Cutâneas/diagnóstico , Idoso , Biópsia , Diagnóstico Diferencial , Evolução Fatal , Humanos , Leucemia Prolinfocítica de Células T/patologia , Masculino , Neoplasias Cutâneas/patologiaRESUMO
Recent work has demonstrated that B-cell cutaneous lymphoid hyperplasia (BCCLH) lies in a spectrum of B-cell lymphoproliferative disorders that can progress to primary cutaneous B-cell lymphoma (CBCL). In light of this work, definitive therapy with methods such as radiotherapy is an important part of the treatment strategy. Few outcome data exist for patients with treatment-resistant BCCLH. We present a case study of a 63-year-old woman with BCCLH who failed immunomodulatory treatment but responded well to an aggressive course of radiotherapy. After 18 fractions of 6 MeV electron beam therapy with 200 cGy per fraction, the patient has been recurrence-free for 3 years. Acute toxicity was limited to Radiation Therapy Oncology Group grade II skin toxicity, which resolved within 1 month of treatment.
Assuntos
Linfócitos B/patologia , Transtornos Linfoproliferativos/radioterapia , Dermatopatias/radioterapia , Feminino , Humanos , Transtornos Linfoproliferativos/patologia , Pessoa de Meia-Idade , Pseudolinfoma/radioterapia , Dermatopatias/patologiaRESUMO
Nevirapine is a non-nucleoside reverse transcriptase inhibitor commonly used in human immunodeficiency virus-1 multidrug regimens and associated with life-threatening cutaneous reactions. Here, we report the successful use of intravenous immunoglobulin in a pediatric patient with Stevens-Johnson syndrome and highlight the risk of nevirapine usage in human immunodeficiency virus postexposure prophylaxis.
Assuntos
Fármacos Anti-HIV/efeitos adversos , Infecções por HIV/tratamento farmacológico , Nevirapina/efeitos adversos , Síndrome de Stevens-Johnson/induzido quimicamente , Adolescente , Fármacos Anti-HIV/uso terapêutico , Relação Dose-Resposta a Droga , Esquema de Medicação , Feminino , Seguimentos , Infecções por HIV/diagnóstico , Soropositividade para HIV , Humanos , Nevirapina/uso terapêutico , Medição de Risco , Índice de Gravidade de Doença , Síndrome de Stevens-Johnson/fisiopatologia , Síndrome de Stevens-Johnson/terapiaRESUMO
A patient is described who presented with the acute onset of widely distributed necrotic papules mimicking pityriasis lichenoides et varioliformis acuta. A skin biopsy revealed granulomatous inflammation and spirochetes were demonstrated. Serologic testing confirmed infection with the Treponema pallidum. Syphilis is still a great imitator and its persistence as an infectious disease is reviewed.
Assuntos
Sífilis Cutânea/diagnóstico , Adulto , Exantema/microbiologia , Granuloma/microbiologia , Humanos , Masculino , Necrose , Pele/patologia , Sorodiagnóstico da Sífilis , Sífilis Cutânea/patologiaRESUMO
Amyloidosis is a broad and complex class of diseases that comprises several etiologies, many manifestations, and a diversity of outcomes. We discuss a patient with primary systemic amyloidosis associated with multiple myeloma that illustrates many of the typical and atypical features of the disease process. Despite more in-depth assessment and accurate classification, survival for patients with primary systemic disease remains poor.
