Veterinary High-Stakes Immersive Simulation Training With Repeat Practice Following Structured Debriefing Improves Students' Ability to Cope With High-Pressure Situations.

INTRODUCTION: Immersive simulation is used increasingly in medical education, and there is increasing awareness of the impact of simulation scenarios on emotional state and cognitive load and how these impact learning.1 There is growing awareness of the requirement to equip veterinarians with skills for managing high-pressure environments and provide training on human factors. METHODS: Veterinary students participated in a high-fidelity immersive simulation of a road traffic collision involving multiple casualties. The students took part in the same simulation twice, the second time after a debrief. Each participant's emotional state and cognitive load were assessed after participating in each simulation. Each participant was asked to score the effect of pressure on their performance. RESULTS: One hundred twenty-five students participated and demonstrated a higher cognitive load with more positive emotional states during the second scenario after the completion of a structured debrief and discussion focusing on pressure relief techniques (cognitive load - ¯µ Scenario run 1 = 4.44 ± 1.85 [SD], ¯µ Scenario2 = 5.69 ± 1.74 [SD]). Most (63%) participants described being in a low-performance state of frazzle during the first scenario compared with most (61%) who described being in a high-performance state of flow during the second. CONCLUSION: Immersive simulation scenarios, with structured debriefing, may allow the measurement of emotional state and cognitive load in participants. Furthermore, this study suggests that curriculum training in human factors and pressure relief techniques, coupled with immersive simulation and debrief, may improve future performance in high-stakes and high-pressure scenarios.

A novel tension relief technique to aid the primary closure of traumatic equine wounds under excessive tension.

BACKGROUND: To achieve an excellent functional and cosmetic result, primary closure is preferred over leaving wounds to heal by secondary intention. However, traumatic wounds are often under excessive tension during wound closure and incorrect suture technique can compromise microcirculation, leading to skin necrosis and impaired wound healing. OBJECTIVE: To describe an inexpensive and effective tension relief technique that helps the successful primary closure of a variety of equine wounds at high risk of dehiscence. STUDY DESIGN: Retrospective case series. METHODS: All wounds that were managed with the Tension Tile System (TTS) at four Equine Hospitals between March 2017 and May 2021 were evaluated. The wounds were classified according to various criteria including anatomical location, time elapsed prior to surgery, depth of wound and post-surgical use of immobilisation. Outcome criteria were based on the success of primary intention healing. The duration of convalescence (weeks) after surgery was also recorded. RESULTS: During the study period, the TTS was used in 191/860 (22%) wounds repaired under general anaesthesia or standing sedation. Overall, primary intention healing (Group A) was achieved in 132 of 191 cases (69%, CI 62%-75%), with partial dehiscence (Group B) in a further 30/191 cases (16%, CI 11%-22%). Severe dehiscence (Group C) was recorded in 29/191 cases (15%, CI 11%-21%). The median convalescence time was 4 weeks (Range 3-15, interquartile range 4-6) in Group A. MAIN LIMITATIONS: Retrospective nature of the study and subjective outcome assessment. The technique was applied to wounds under significant tension; however, this was based on a subjective assessment by the surgeons involved. CONCLUSIONS: The Tension Tile System is an economical and effective technique for challenging equine wounds under tension, in a variety of anatomical locations.

Comparison of incisional bursting strength of a bidirectional absorbable knotless suture material versus a standard continuous absorbable suture material for closure of the equine linea alba.

OBJECTIVE: To evaluate the use of bidirectional knotless barbed suture material for closure of the equine linea alba. STUDY DESIGN: Laboratory study. ANIMAL OR SAMPLE POPULATION: Adult light horse cadavers (n = 24). METHODS: A 25 cm incision was made through the linea alba, and a 200 L polyurethane bladder was positioned within the abdomen. The linea alba was closed either using USP2/EP5 bidirectional polydioxanone barbed suture or USP2/EP5 standard polydioxanone suture in a simple continuous pattern. Closure time was recorded for each suture type. The bladder was air-insufflated at 40 L/min, and the pressure at body wall failure recorded. The length of suture used for wound closure and wound failure modes were recorded. Suture length, closure time, bursting pressure, and failure modes were compared using Welch-Aspin t-tests. RESULTS: The incisional bursting pressure was comparable between the two groups (p > .05). Less suture material (p < .01) was required with the barbed suture than the standard suture. Closure time was less for the barbed suture than the standard suture (p < .01). Suture failure was the main failure mode in both groups (83% cases). CONCLUSIONS: Closure of the equine linea alba using bidirectional barbed suture material reduced the amount of foreign material in the wound and decreased closure time without compromising incisional strength. CLINICAL RELEVANCE: Bidirectional barbed suture material could be considered as an alternative to standard suture materials for closure of the equine line alba.

Standing thyroidectomy in 10 horses.

OBJECTIVE: To describe a surgical technique for thyroidectomy in horses with thyroid neoplasia under standing sedation and local anesthesia. STUDY DESIGN: Retrospective study. ANIMALS: Client-owned horses (n = 10). METHODS: Medical records of horses with a history of thyroid enlargement were included in the study if thyroid gland enlargement was treated surgically via hemi- or bilateral thyroidectomy, with the horse standing and sedated. Data derived from follow-up clinical examination, performance level, recurrence, and cosmetic outcome were evaluated. RESULTS: Thyroid enlargement was unilateral in 8 and bilateral in 2 horses. Histopathological findings included adenomas (5/10), adenocarcinomas (2/10), cystic hyperplasia (2/10), and C-cell adenoma (1/10). No major complications were encountered during or after surgery. All horses resumed their previous level of exercise within 6 weeks. Recurrence was diagnosed in 1 horse, 7 months after excision, and a second surgery was required. Recurrent laryngeal nerve neuropathy and seroma formation subsequent to surgery were not recorded in any of the cases. CONCLUSION: Thyroidectomy can safely be performed with the horse standing and sedated with local anesthesia. CLINICAL RELEVANCE: Performing standing thyroidectomy does not increase intraoperative or postoperative complications and could be considered for horses with thyroid enlargement amenable to surgery.

Angiographic anatomy of the extracranial and intracranial portions of the internal carotid arteries in donkeys.

BACKGROUND: In horses, the extracranial and intracranial pathway of the internal carotid artery has been described. The extracranial pathway of the internal carotid artery begins at the carotid termination and runs on the dorsal surface of the medial compartment of the guttural pouch. Thereafter the internal carotid artery passes through the foramen lacerum to continue intracranially, forming part of the rostrolateral quadrants of the cerebral arterial circle (Circle of Willis). The objectives of this study were to define and record the anatomy of the carotid arterial tree and the internal carotid artery in donkeys using angiographic techniques. This is a prospective descriptive study on 26 cadaveric donkeys. METHODS: Twenty six donkey cadavers of mixed, age, sex and use presented for reasons unrelated to disease of the guttural pouch were subjected to carotid and cerebral angiography using rotational angiography. Rotational angiographic and 3 dimensional multiplanar reconstructive (3D-MPR) findings were verified with an arterial latex casting technique followed by dissection and photography. RESULTS: The following variations of the carotid arterial tree were identified: [1] the internal carotid and occipital arteries shared a common trunk, [2] the linguofacial trunk originated from the common carotid artery causing the common carotid artery to terminate as four branches, [3] the external carotid artery was reduced in length before giving rise to the linguofacial trunk, mimicking the appearance of the common carotid artery terminating in four branches, [4] the internal carotid artery originated at a more caudal position from the common carotid artery termination. CONCLUSION: Veterinarians should be aware that considerable variation exists in the carotid arterial tree of donkeys and that this variation may differ markedly from that described in the horse.

Angiographic Variation of the Internal Carotid Artery and its Branches in Horses.

OBJECTIVES: To record the angiographic anatomy of the equine internal carotid artery (ICA) using angiography techniques. STUDY DESIGN: In vitro descriptive study. SAMPLE POPULATION: Equine cadaver specimens (n = 50). METHODS: Head and neck specimens from horses of mixed breed, age, sex, and use without a history of guttural pouch disease had carotid and cerebral angiography using conventional (n = 7) and rotational angiography (43). Angiographic findings were verified by arterial latex casts. RESULTS: Variation in ICA anatomy was categorized into 4 groups: (1) the internal carotid and occipital arteries arising as a common trunk; (2) an aberrant branch of the extra-cranial ICA connected to the basilar artery; (3) an aberrant branch of the ICA ramifying into the surrounding tissue and not connected to any other vessels; and (4) an aberrant branch of the ICA giving rise to several smaller satellite branches, including connections to the caudal branch of the ipsilateral occipital artery. CONCLUSION: Rotational angiography is useful for identification of anatomic variation in the ICA that could be important in achieving vascular occlusion in the treatment of guttural pouch mycosis.

Diagnosis and treatment of dynamic collapse of the cricotracheal ligament in thoroughbred racehorses.

OBJECTIVE: To describe (1) diagnosis of dynamic collapse of the cricotracheal ligament in a group of horses and (2) treatment and outcome of affected horses. STUDY DESIGN: Retrospective case series. ANIMALS: Thoroughbred horses (n = 8). METHODS: Of 600 over ground dynamic endoscopic examinations performed, 8 Thoroughbred horses had cricotracheal ligament collapse (CTLC); 5 were 2 years old and in early training and 2 were mature horses in full work. CTLC was diagnosed if circumferential collapse of the cricotracheal ligament was identified during exercise. Seven horses had repeat endoscopic examination. Two horses unresponsive to conservative management were treated surgically. RESULTS: Multiple abnormalities of the upper portion of the respiratory tract were identified along with CTLC in all five 2-year-old horses and resolution of CTLC was observed after treatment for upper airway inflammation. No concurrent respiratory abnormality was identified in the 2 mature horses. Surgical reduction of the cricotracheal space and imbrication of the cricotracheal ligament of these 2 horses resulted in resolution of clinical signs of CTLC. CONCLUSIONS: CTLC is a rare cause of dynamic obstruction in Thoroughbred racehorses. Resolution may occur after adaptation to training and after inflammation of the respiratory tract is resolved, but for horses with persistent CTLC, surgical reduction of the cricotracheal space and imbrication of the cricotracheal ligament may result in resolution of clinical signs.

Local anesthesia and hydro-distension to facilitate cystic calculus removal in horses.

OBJECTIVE: To report a technique for improving surgical access to the bladder for removal of cystic calculi in male horses. STUDY DESIGN: Retrospective case series. ANIMALS OR SAMPLE POPULATION: Geldings (8) with cystic calculi. METHODS: After catheterization of the bladder through the penis, 100 mL 2% lidocaine hydrochloride solution was instilled. After 10 minutes, the bladder was distended with sterile, warmed Hartmann's solution to a pressure of ≈ 40 cm H(2) O, using gravity feed. This was left in place until abdominal access was gained at surgery, then the fluid siphoned off via the catheter. RESULTS: Calculi were 3-11 cm in diameter (median, 6 cm). Bladder capacity ranged from 1.4 to 2.5 L (median, 1.8 L). Exteriorization time from placing a hand in the abdomen to having the bladder in a surgically accessible position was <5 minutes. CONCLUSION: The described technique facilitates exteriorization of the bladder for removal of cystic calculi.

Radiographic evaluation of the modified Brunelli technique versus the Blatt capsulodesis for scapholunate dissociation in a cadaver model.

PURPOSE: A variety of soft tissue surgical procedures have been developed for treatment of scapholunate (SL) dissociation. The purpose of this study was to compare the degree of correction obtained (as measured on preoperative and postoperative radiographs) when performing the modified Brunelli technique (MBT) with that of the more commonly performed Blatt capsulodesis (BC) and to evaluate each technique after simulated wrist motion. METHODS: Five cadaver wrists were used for this study. The SL interval, SL angle, and radiolunate angle were recorded radiographically, with the SL ligament intact, for each wrist in several loaded positions: neutral, flexion, extension, radial deviation, ulnar deviation, and clenched fist. The SL interosseous ligament was then completely incised, and the radiographic measurements were repeated to demonstrate SL instability. The radiographic measurements were then repeated after MBT reconstruction and after BC reconstruction. Additional radiographic measurements were taken after simulated wrist motion. RESULTS: Sectioning of the SL ligament resulted in radiographic evidence of SL dissociation. Use of the MBT demonstrated improved correction of the SL interval and the SL angle in the clenched fist position, which was statistically significant when compared with BC. The correction for the SL angle was maintained on the MBT specimens with simulated wrist motion. CONCLUSIONS: The results demonstrate that in this cadaver model, the MBT better restores the normal carpal relationship of the SL interval and SL angle when compared to the BC, as measured on radiographs. This correction might correlate with improved carpal dynamics and improved clinical outcomes.

Pictet-Spengler based synthesis of a bisarylmaleimide glycogen synthase kinase-3 inhibitor.

A practical synthesis of the glycogen synthase kinase-3 (GSK3) inhibitor bisarylmaleimide 1 has been accomplished employing Pictet-Spengler methodology to access the indole 7-position in preparing the benzodiazepine tricyclic fragment. A seven-step linear sequence that starts with commercially available 5-fluoroindole 7 affords the bisarylmaleimide 1 in 33% overall yield.

Surgical treatment of septic jugular thrombophlebitis in nine horses.

OBJECTIVE: To report a technique for surgical treatment of septic jugular thrombophlebitis unresponsive to medical treatment. STUDY DESIGN: Case series. ANIMALS: Horses (n=9) with septic jugular thrombophlebitis unresponsive to medical treatment. METHODS: Jugular vein thrombectomy was performed under standing sedation and local anesthesia. The contents of the affected portion of vein were removed by multiple incisions in the vein, with the incisions left open to drain and heal by second intention. RESULTS: The technique was curative in all instances, although 2 horses required a 2nd procedure. One horse required ligation of the linguofacial vein to control postsurgical hemorrhage. CONCLUSIONS: The technique is an effective surgical treatment for septic jugular thrombophlebitis unresponsive to medical treatment. CLINICAL RELEVANCE: Jugular vein thrombectomy is a straightforward technique, and has minimal postoperative complications. It allows expedient and cost-effective resolution of medically recalcitrant cases of septic jugular thrombophlebitis.

Repeat laparotomy for the treatment of septic peritonitis in a Bornean orangutan (Pongo pygmaeus pygmaeus).

A 9-yr-old female Bornean orangutan (Pongo pygmaeus pygmaeus) presented with a 48-hr history of depression, lethargy, anorexia, and mucoid discharge from the rectum. Clinical, radiographic, and ultrasonographic examination demonstrated the presence of multiple distended loops of intestine, intestinal adhesions, and free gas within the abdomen. During exploratory laparotomy, fibrinopurulent diffuse peritonitis as a result of a ruptured intrapelvic abscess with associated large bowel adhesions was evident. The abdomen was thoroughly lavaged, necrotic debris and abscess wall removed, and fibrinous adhesions disrupted. The orangutan was kept sedated for 48 hr to allow for intensive care. Six months later, when the orangutan presented with similar clinical signs, ultrasonographic examination demonstrated the presence of a pelvic abscess. The previous procedure was repeated with the addition of a hysterectomy. This report is the first documentation of long-term management following surgical intervention for internal abdominal abscessation and septic peritonitis in a great ape.

Transpalpebral eye enucleation in 40 standing horses.

OBJECTIVE: To report a technique for eye enucleation in standing sedated horses and to report outcome in 40 horses. STUDY DESIGN: Retrospective study. ANIMALS: Horses (n=40) requiring eye enucleation. METHODS: The eye was enucleated using a transpalpebral technique in 40 horses restrained in stocks and sedated. Anesthesia of orbital structures was provided by local nerve blocks and infiltration of the surgical site with local anesthetic solution. RESULTS: Affected eyes were successfully enucleated with the horse standing. Short-term complications included moderate swelling (5 horses) and wound discharge (1). Long-term complications were not observed. CONCLUSIONS: A diseased eye can be safely enucleated with a horse standing. CLINICAL RELEVANCE: Enucleating an equine eye in the standing position eliminates the risks and costs of general anesthesia.

Surgical correction of wry nose in four horses.

OBJECTIVE: To describe surgical techniques used for correction of congenital nasal deviation (wry nose) in horses (wry nose) and to report outcome. STUDY DESIGN: Retrospective study. ANIMALS: Horses (n=4), 5-17 months old with wry nose. METHODS: Nasal deviation was corrected by transecting the premaxillae/maxillae and nasal bones at their site of maximum curvature and realigning and stabilizing the bones in a more normal alignment using internal fixation. The nasal septum was removed during the same anesthetic period. RESULTS: For each horse, physical appearance was improved and respiratory stridor eliminated. CONCLUSIONS: Wry nose can be corrected by transecting the premaxillae/maxillae and nasal bones and stabilizing the transected bones in a more normal alignment; the nasal septum can be removed concurrently. CLINICAL RELEVANCE: Surgical correction of wry nose may provide a good functional and cosmetic outcome.

Subtotal ostectomy of dorsal spinous processes performed in nine standing horses.

OBJECTIVE: To describe and evaluate subtotal ostectomy of dorsal spinous processes (DSP) performed in standing horses. STUDY DESIGN: Retrospective study. SAMPLE POPULATION: Nine adult horses. METHODS: The diseased portions of the DSP were removed with the horses standing and sedated after infiltrating a local anesthetic agent around the affected DSP. Medical records of affected horses were reviewed to determine history, findings of physical and radiographic examination, surgical technique, postoperative complications, and outcome. RESULTS: Five horses had subtotal ostectomy of DSP because of osteomyelitis, and 4 because of impingement and/or fracture of DSP. Affected portions of DSP were removed safely and effectively, with no apparent discomfort to the horses; hemorrhage was minimal. CONCLUSIONS: Subtotal ostectomy of DSP can be performed safely in standing, conscious horses and the risks associated with general anesthesia are eliminated. Hemorrhage is minimal compared to that which occurs when the procedure is performed with horses anesthetized and in lateral recumbency. CLINICAL RELEVANCE: Access and visibility are better when subtotal ostectomy of the DSP is performed with the horse standing rather than anesthetized and in lateral recumbency. Performing subtotal ostectomy of diseased DSP with the horse standing avoids the expense and risks of general anesthesia.