[Experimental research on the use of fluorocarbon compounds (FC 43) as blood substitutes]. / Ricereca sperimentale sull'impiego dei composti fluorocarbonici (FC 43) come sostituti ematici.

The authors have experimented a fluorocarbon compound (FC 43) in form of a stable emulsion (20%), in the presence of a suitable surfactant agent (Pluronic F 68: 2,5%), as an hematic substitute. The animals (fifteen rabbits) underwent substitution of 50% of the total hematic volume with same volumes of the emulsion and thereafter have been examined for a period of twenty-four hours. During the time of observation there were no changes on: 1) acid-base equilibrium; 2) respiratory homeostasis and 3) major circulatory parameters.

[An experimental investigation of the use of a fluorocarbon (FC 43) as blood substitute]. / Ricerca sperimentale sull'impiego di un fluorocarbonato (FC 43) come sostituto ematico.

A fluorocarbonate emulsion was infused into 30 rabbits after the removal of varying amounts of blood. Parameters relating to the transport of respiratory gases and the fundamental features of the macrocirculation were monitored. The animals were sacrificed after 6 or 24 hr and the histological changes in the main parenchymas were assessed. The material injected displayed low toxicity, a good ability to act as a vehicle for oxygen and carbon dioxide, and no tendency to alter the macrocirculation. Numerous problems remain, however, with regard to the stability of fluorocarbonates over the course of time and the effect of their uptake by tissues.

[Parenchymal morphology after oxygenated alveolar lavage (L.A.O.) with liquid fluorocarbons]. / Rilievi morfologici parenchimal i dopo lavaggio alveolare ossigenannte (L.A.O.) con fluorocarbonati liquidi.

A series of experiments was carried out to determine histological damages in rabbit's lung, liver, kidney and brain after oxygenated alveolar lavage (L.A.O.).