[Perspectives and possibilities of luminescent differential diagnosis in endoscopy of stomach ulcers]. / Perspektivy i vozmozhnosti liuminestsentnoi differentsial'noi diagnostiki v éndoskopii iazv zheludka.

On the basis of 1800 examinations of tumor cells the authors show possibility for accumulation of luminescent dye uranine by malignant cells. The conception of the mechanism of its accumulation, confirmed by the studies of reinoculated tumors of rats (60 examinations) is presented. Of 821 patients with ulcers of the stomach 641 had no luminescence; at repeated examination cancer and ulcer were revealed in 7 of them. Malignant transformation was verified by histologic method in 102 of 180 patients with luminescent ulcers. In 22 patients intestinal metaplasia was detected in the luminescence areas and in 40--there was a rough epitnelial dysplasia. At the examination of these patients two years later, cancer of the stomach at the sites of previously revealed luminescence was detected in 15 patients (26.3%).

Fluorescent diagnostics of human gastric cancer and sodium fluorescein accumulation in experimental gastric cancer in rats.

Patients (459) with chronic gastritis, ulcers, polyposis and different types of gastric cancers were examined by endoscopic fluorescent technique using a special drug based on the sodium salt of fluorescein (F1). Eighty-five percent of gastric cancers showed positive fluorescence. The F1 distribution in the stomach of the rat with induced gastric cancer was examined. In all cases the level of F1 fluorescence in the tumor was higher than in the adjacent normal tissues of the stomach. Thus, all the obtained results confirm the selective accumulation of F1 in tumors of the stomach.

[Use of the fluorescent analysis in early diagnosis of cancer of the stomach]. / Ispol'zovanie fluorestsentnogo analiza v rannei diagnostike raka zheludka.

The effectiveness of a fluorescent analysis in the diagnosis of gastric cancer was studied in 280 patients. Fluorescence of a tumor was noted in 87% of cases. Dependence of fluorescence of a tumor on its sizes was revealed: in tumor diameter less than 1 cm, fluorescence was revealed in 94% of cases, more than 4 cm--in 76%. In infiltrative growth, only 74% of tumors were fluorescent. To define the possibility of the use of a fluorescent analysis in the differential diagnosis of gastric diseases, 490 patients with presumptive diagnosis of chronic gastritis, gastric ulcer disease, polyposis were examined. In diagnosis of +malignant polyps in 91.5% of cases, results of the fluorescent analysis concurred with the findings of histologic study. Probability of establishing the correct diagnosis by the data of fluorescent analysis in ulcer disease is equal to 87.5%, in chronic gastritis--86%.

[Morphologic evaluation of the potential of fluorescent analysis in the diagnosis of gastric diseases]. / Morfologicheskaia otsenka vozmozhnostei fliuorestsentnogo analiza v diagnostike zabolevanii zheludka.

A method based on the secondary luminescence of malignant tumours facilitates a more precise taking of biopsies in ulcers and polyps undergoing malignant transformation in carcinoma developing against gastritis background as well as during emergency intraoperative diagnosis. 478 gastroscopies were performed in order to clarify the correlation between fluorescence and the presence of carcinoma in the luminescent biopsies. Biopsies were obtained from both fluorescent and non-fluorescent areas. Besides that, fluorescent study of operative edges of 117 stomachs removed because of carcinoma was carried out. It is proved that the use of fluorescent method increases the value of biopsies.

[Potentialities of a fluorescent method in determining the completeness of resection of the stomach in cancer]. / Vozmozhnosti fliuorestsentnogo metoda v opredelenii polnoty rezektsii zheludka pri rake.

Examined were 78 resected stomachs of the patients, operated on for infiltrative cancer. Before the operation, a fluorescent dye was injected to all the patients. Fluorescence was excited by light with a wavelength of 441 nm, and fixed at the wavelength of the dye fluorescence of 520 nm. In histologic study of the brightly fluorescing sites, it was established that in 3 cases, the resection was performed through the tumour, and in 4--a tumour was invading along the tela submucosa and muscular layer up to the margin of resection.

[Changes in the biochemical indices of liver function in stomach and esophageal cancer]. / Izmenenie biokhimicheskikh pokazatelei funktsii pecheni pri rake zheludka i pishchevoda.

In 190 patients with cancer of the esophagus and stomach the authors have studied biochemical values of blood which reflect the liver function prior to and after the operation but in some patients before death. Moreover, in 98 cases puncturing of the liver was performed with histological assay of the needle biopsy specimen. Based on the clinico-biochemical and morphological correlations, it was found that the patients prior to surgery develop a manifest or obscure hepatic insufficiency on the background of hydropic or balloon dystrophy or acute reactive hepatitis, which in some cases may not be manifested preoperatively by biochemical changes in blood. Postoperatively, these patients would develop a marked progressing hepatic or hepatorenal insufficiency being the direct cause of death in 29.4% of cases. In patients with an evident discord in the clinical state and the degree of biochemical changes in blood, it seems rational to perform preoperative needle biopsy of the liver to reveal the grade of its involvement and to carry on an adequate therapy.