[The postamputation syndrome in rats and its neurochemical characteristics]. / Postamputatsionnyi sindrom u krys i ego neirokhimicheskie kharakteristiki.

Noradrenergic and GABA-ergic systems were correlated and dominated in the processes of spinal cord segmentary apparatus superactivity compensation. An increase in c-GMP content in the spinal cord suggests an intensification of the activation mechanism. An increase in the c-AMP content may suggest an inhibition of the compensatory intensification of noradrenergic or GABA-ergic mechanisms.

[Dynamics of calmodulin in cerebral structures under the action of modulated UHF electromagnetic fields]. / Dinamika kal'modulina v strukturakh mozga pri vozdeistvii modulirovannogo SVCh-polia.

The influence of modulated UHF-electromagnetic fields (low intensity) on calmodulin levels in several brain structures was studied. It was shown that UHF-electromagnetic fields influence calmodulin levels in the hypothalamus and sensorimotor cortex. Its effect depends on modulation regimes.

[New adenosine derivatives as agents to prevent postischemic disorders]. / Novye proizvodnye adenozina kak sredstva profilaktiki postishemicheskikh narushenii.

The authors studied prophylactic action of adenosine analogs during ischemic liver damage. Hepatoprotective action of adenosine analogs was established.

[Effects of diazepam and N(6)-cyclohexyladenosine on the level of diazepam-binding inhibitor in structures of the hippocampus during immobilization stress]. / Vliianie diazepama i 6N-tsiklogeksiladenozina na uroven' diazepamsviazyvaiushchego ingibitora v strukturakh gippokampa na fone immobilizatsionnogo stressa.

The Diazepam-binding inhibitor (DBI) levels were studied under stress-reaction condition and after diazepam and N6-cyclohexyladenosine injections. The radioimmune method was used to study the DBI levels. It was shown, that DBI level increased during stress-reaction. Diazepam and N6-cyclohexyladenosine injection decreased DBI level in these conditions. On the basis of these data the authors proposed the hypothetic model of interaction between adenosine receptors and GABA-Benzodiazepine-receptor complex.

[Binding of adenosine analogs with A1-type purine receptors in the guinea pig ileum]. / Izuchenie sviazyvaniia analogov adenozina s purinovymi retseptorami A1-tipa v podvzdoshnoi kishke morskoi svinki.

Several N6-adenosine analogs were synthesized and their A1-purine receptor binding affinities were determined. Our results demonstrate that N6-allyl- and N6-aminopropanol-adenosine increase affinities to A1-purine receptor in guinea pig ileum.

[The effect of adenosine and its derivatives on the dynamics of delayed activity and the calmodulin level in various structures of the brain]. / Vliianie adenozina i ego proizvodnykh na dinamiku medlennoi aktivnosti i uroven' kal'modulina v nekotorykh strukturakh golovnogo mozga.

The adenosine and A1-adenosine receptor agonists produced shifts of DC potential and decreased the calmodulin levels in the animal hypothalamus.

[Effect of adenosine on cyclic nucleotide levels in brain structures]. / Vliianie adenozina na soderzhanie tsiklicheskikh nukleotidov v strukturakh golovnogo mozga.

Adenosine influence on cAMP and cGMP levels in cortex, hypothalamus, hippocampus and cerebellum was studied. It was established that adenosine and inhibitor of its reuptake--dipyridamole change cyclic nucleotide levels in some structures of brain (intraperitoneal injection). It was shown that cAMP and cGMP were in reciprocal relations in cortex, but not in hypothalamus, hippocampus and cerebellum.

[Anti-arrhythmic action of adenosine and the cyclic nucleotide content of the myocardium of rats with ischemia]. / Antiaritmicheskoe deistvie adenozina i soderzhanie tsiklicheskikh nukleotidov v miokarde krys pri ishemii.

In anesthetized rats a 30-min intravenous infusion of adenosine (2.5 mg/kg/min) performed after the coronary artery ligation significantly decreased the incidence and severity of early ischemic arrhythmias. After the infusion of adenosine, there was an increase in cGMP level in the left ventricular myocardium, cAMP content remained unchanged.

[Effect of catecholamines and corticosteroids on the cyclic nucleotide level in the splenic cells of immunized and nonimmunized rats]. / Vliianie katekholaminov i kortikosteroidov na uroven' tsiklicheskikh nukleotidov v kletkakh selezenki u immunizirovannykh i neimmunizirovannykh krys.

Red blood cells of sheep were shown to increase cAMP and cGMP levels in the rat spleen cells. The noradrenaline and adrenaline levels increased within first minutes after immunization in spleen tissue. Adrenalectomia counteracted the increase of cAMP and induced no change in the cGMP levels in spleen cells. HJydrocortisone (50 mg/kg) inhibited cyclic nucleotide responses to the sheep red blood cells.