[Local sorption-detoxication therapy in combined treatment of acute purulent paraproctitis]. / Mestnaia sorbtsionno-detoksikatsionnaia terapiia v kompleksnom lechenii ostrogo gnoinogo paraproktita.

Efficacy of sorption-detoxication therapy (sorbent SUMS-1) in combined treatment of acute purulent paraproctitis was evaluated. Degree of endotoxication, state of postoperative wound, structural and morphological state of mucosous membrane of the rectum (light, electron microscopy, morphometry of biopsies) were studied. It was found that local use of sorbent increases efficacy of treatment of severe paraproctitis: endotoxicosis eliminates, regional hemo- and lympho-circulation improves, wound regeneration activates.

[The general biological principles of the development of complications in the postoperative period of acute peritonitis and the expediency of hemosorption]. / Obshchebiologicheskie zakonomernosti formirovaniia oslozhenii v posleoperatsionnom periode ostrogo peritonita i tselesoobraznost' gemosorbtsii.

The dynamic study of a number of clinical and laboratory findings in 107 patients with acute peritonitis have shown that with the current complex infusion therapy the onset of postoperative complications is to a great extent mediated by high toxin level--medium molecular mass polypeptide, inhibiting the processes of protein synthesis and consequently causing changes in the relationship between adaptation compensatory reactions, which demonstrates the necessity of additional active detoxicating therapy, i.e. hemosorption (HS). HS was performed to 126 patients and its efficacy in pronounced toxemia was established. The data obtained make it possible to consider HS as an effective means preventing the onset of postoperative complications in acute peritonitis.

[Immunologic effect of hemosorption in patients with acute peritonitis]. / Immunokorrigiruiushchii éffekt gemosorbtsii uu bol'nykh ostrym peritonitom.

An examination of 65 patients with acute diffuse peritonitis has shown that pronounced T-immune deficiency is observed in the postoperative period of acute peritonitis. Hemosorption was shown to be efficient in patients with high content of toxin which allows considering the method of extracorporeal detoxication as effective means of immune-correcting therapy in peritonitis patients with high level of toxinemia who make up a group of risk.

[Extracorporeal detoxification of the body and the B system of immunity in acute peritonitis]. / Ekstrakorporal'naia detoksikatsiia organizma i B-sistema immuniteta pri ostrom peritonite.

65 patients with acute peritonitis of various etiology have been examined. It has been established that marked toxemia in the early postoperative period, normal relative B-lymphocyte content, low level of EAC-RFC with moderate to high content of receptors to sheep red blood cells are prognostically unfavourable. The level of intermediate molecular mass polypeptides (IMMP) above 0.4 units and absolute absence of B lymphocytes with high receptor density during one postoperative week seem threatening and are an indication for hemosorption (HS). HS in patients with high toxin content was accompanied by a positive clinical effect related to its non-specific stimulation of qualitative and functional B-lymphocyte properties including their receptor apparatus due to IMMP removal from blood.

[Adaptation reactions in acute peritonitis and their correction using sorption detoxification]. / Adaptatsionnye reaktsii pri ostrom peritonite i ikh korrektsiia s pomoshch'iu sorptsionnoi detoksikatsii.

Examined were 233 patients with acute peritonitis. In patients, who underwent the conventional intensive infusion therapy alone, in complicated course of the postoperative period, within 28 days, the high level of pathologic stress reactions was observed, which correlated with changes in the content of middle molecular mass peptides (MMMP). In uncomplicated course of the postoperative period, the MMMP level and adaptation reactions didn't differ from the control findings. Hemosorption in patients with high toxin level was accompanied by the decline in MMMP concentration below the diagnostic level, restoration of physiologic adaptation reactions.

[Immunologic reactivity and sorption detoxication of patients with acute peritonitis]. / Immunologicheskaia reaktivnost' i sorbtsionnaia detoksikatsiia bol'nykh ostrym peritonitom.

Follow-up using immunological monitoring of 233 acute peritonitis patients revealed various immunological shifts occurring at all levels postoperatively, with the therapeutic methods being common. Depression of specific immune response mechanisms (T- and B-systems) along with disinhibited phylogenetically old forms of the common biological phenomenon non-specific immunity (phagocytosis) is believed to reflect the common adaptive mechanism activated in emergencies in patients with peritonitis. With high levels, the toxin median molecular mass polypeptide in the complicated postoperative course, the immunological impairment is more pronounced, while restoration of immunological responsiveness of the organism becomes protracted, resulting in reduction of the cellular homeostasis and metabolism reserved. Application of the extracorporeal detoxication-hemosorption promotes adaptation buildup and makes immunity functioning optimal.

[Effect of hemosorption on the level of medium molecular mass polypeptides and humoral immunity in patients with peritonitis]. / Vliianie gemosorbtsii na uroven' polipeptidov srednei molekuliarnoi massy i gumoral'nyi immunitet u bol'nykh peritonitom.

An examination of 43 patients with acute diffuse peritonitis of various etiology has revealed different direction of the dynamics of indices of humoral immunity (M, G, A immunoglobulins, general complement activity, circulating immune complexes) depending on the level of middle mass polypeptides (MMP) in the patient's blood. Hemosorption in peritonitis was established to allow rapid and effective elimination of MMP in patients with high content and thus control critical endotoxicosis.

[Insulin-depositing function of peripheral blood erythrocytes in rats that have sustained severe craniocerebral injury]. / Insulindeponiruiushchaia funktsiia éritrotsitov perifericheskoi krovi u krys, perenesshikh tiazheluiu cherepno-mozgovuiu travmu.

Rats with a grave craniocerebral injury were examined over time for the content of insulin in red cells (1, 3, 7, 14, 21 and 35 days after injury). Alterations were found in the affinity of circulating red cells for paraaldehyde fuchsin (PAF), linked primarily with a decrease in the proportion of the PAF-resistant forms of the cells. It is suggested that in general the data obtained reflect the intensification of the receptor function of the red cell membrane.

[Effect of collateral blood flow on the effectiveness of embolectomy in an experiment and in clinical practice]. / Vliianie kollateral'nogo krovotoka na éffektivnost' émboléktomii v éksperimente i klinike.

On the basis of an experimental study (44 dogs) and examination of 250 patients with arterial embolism the authors give grounds for a complex of intensive spasmolytic therapy eliminating the arterial spasm and stimulating collateral circulation which allows wider indications for embolectomy in later terms.

[Optimizing surgical tactics for treating injuries of the major arteries of the extremities based on predictions of the efficacy of the restorative surgery]. / Optimizatsiia khirurgicheskoi taktiki lecheniia travm magistral'nykh arterii konechnostei na osnove prognozirovaniia éffektivnosti vosstanovitel'no operatsii.

The algorithm elaborated to predict the efficacy of restorative surgery makes it possible to determine reliably the viability of the limb on the basis of ordinary clinical data and may be used for selecting a method of surgical intervention in an individual patient with an injured major artery.

[Use of the antioxidant ionol to prevent damage to the heart from prolonged administration of antitubercular preparations]. / Ispol'zovanie antioksidanta ionola dlia preduprezhdenia povrezhdenii serdtsa, vyzvannykh dlitel'nym vvedeniem protivotuberkuleznykh preparatov.

Prolonged administration of isoniazid, protionamide and rifampicin to white rats is accompanied by marked depression of myocardial contractile function determined by the distress of membranous mechanisms of calcium transport because of excessive activation of lipid peroxidation in cardiomyocyte biomembranes. Administration of ionol coupled with antituberculous drugs prevents their cardiotoxic effects.

[Role of lipid peroxidation in damage to brain neurons during ischemia and in the postischemic period]. / Rol' perekisnogo okisleniia lipidov v povrezhdenii neironov mozga pri ishemii i v postishemicheskom periode.

It has been demonstrated in experiments on rats that highly activated lipid peroxidation in brain tissue during ischemia and early postischemic period gives rise to injuries of membrane structures of neurons and to formation of lysosomes that subsequently aggravate neuronal destruction.

[Arterial embolism and acute thrombosis in patients with arteriosclerosis and rheumatic heart disease]. / Arterial'naia emboliia i ostrye trombozy u bol'nykh aterosklerozom i revmaticheskimi porokami serdtsa.

The results of diagnosis and treatment of patients with atherosclerosis and rheumatic heart disease are reported (150 cases of embolism and 39 cases of acute thrombosis in the aorta and main arteries of the limbs). The diagnosis was late in 73.3% of the patients, for which reason 22% were admitted with the third stage of the disease. Embolectomy was performed in 111 cases, amputation of a limb without blood flow recovery in 7, and conservative treatment was conducted in 32 cases. Postoperative mortality was 13.7%, and amputation rate 12.5%. Thirteen thrombectomies and 12 reconstructive operations were performed in patients with acute aortofemoral thromboses. Improved diagnosis is expected to reduce postoperative mortality and amputation rates.