[Dental gel Cholisal at the stage of conservative treatment of inflammatory periodontal diseases]. / Stomatologicheskii gel' Kholisal na etape konservativnogo lecheniya vospalitel'nykh zabolevanii parodonta.

PURPOSE OF THE STUDY: To study the effectiveness of using the drug Cholisal as part of the conservative treatment of chronic periodontitis. MATERIAL AND METHODS: We selected 100 patients aged 35 to 65 years of both sexes with a diagnosis of moderate chronic periodontitis in the acute phase with a periodontal pocket depth of 3.5-5 mm. Depending on the tactics of conservative treatment of CGP, patients were divided into two groups of 50 people. In the main group, in addition to standard treatment, the dental gel Cholisal was used, and in the control group, therapy was standard. 10 days after professional hygiene, patients in both groups were examined and underwent an index assessment of the condition of periodontal tissues and adherence to treatment. RESULTS: In patients of the control group, 10 days from the start of treatment, the depth of periodontal pockets in the control group decreased slightly from 4.7±0.28 mm to 4.2±0.21 mm (p=0.074), and the Green-Vermillion hygiene index decreased by 25.3±1.79% (p=0.041), Silnesse-Loe plaque index by 59.1±2.16% (p<0.001), PMA index by 51.5±1.92% (p<0.001) and Muhlemann-Cowell bleeding index by 42.2±1.75% (p<0.001). In the main group, the effectiveness of treatment of chronic periodontitis with conservative therapy using Cholisal was higher. There was a statistically significant decrease in the depth of periodontal pockets from 4.8±0.23 mm to 3.5±0.19 mm (p=0.043), the Green-Vermillion hygiene index decreased by 47.6±2.13% (p=0.0003), Silnesse-Loe plaque index by 78.2±3.05% (p<0.001), PMA index by 69.4±2.74% (p<0.001) and Muhlemann-Cowell bleeding index by 66.9±1.62% (p<0.001). CONCLUSIONS: The use of the drug Cholisal in the conservative treatment of chronic periodontitis has shown convincing positive dynamics in both subjective and objective assessments, which suggests its effective use.

[Diagnostic possibilities of laboratory assessment of cathepsin K activity in gingival and peri-implant fluid under normal conditions and periimplantitis]. / Diagnosticheskie vozmozhnosti laboratornoi otsenki aktivnosti katepsina K v desnevoi i periimplantatsionnoi zhidkosti v norme i pri periimplantite.

OBJECTIVE: The aim of the work was to develop a non-invasive laboratory method for local control of the severity of osteo-destructive processes in the bone tissue of the jaws after dental implantation. MATERIALS AND METHODS: The study comprised 75 individuals aged 18 to 65. The main group included 40 patients with a diagnosis of dental periimplantitis (ICD K 10.2). A comparison group (n=20) included patients after dental implantation without postoperative complications. The control group (n=25) consisted of individuals without dental pathology. Cathepsin K (CTSK) (Human) ELISA Kit (Cloud-Clone Corp., USA) was used to determine the concentration of cathepsin K by the enzyme immunoassay in the gingival or peri-implant fluid. RESULTS: The concentration of cathepsin K in the gingival fluid in the patients of the control group was 1.7±0.3 pmol/l, in the comparison group the concentration of the studied biomarker corresponded to 2.3±0.4 pmol/l. In the main group, the concentration of cathepsin K in the exudate of peri-implantation pockets increased 2.8 times (p<0.05) and corresponded to 4.9±0.5 pmol/l. The concentration of cathepsin K in the gingival fluid normally did not depend on age and gender, which increased the independence of the osteomarker for characterizing the osteoresorbent process in the peri-implantation area. After dental implantation, an excess of cathepsin K concentration above the level of 2.7 pmol/l with a diagnostic sensitivity of 82.5% and a specificity of 83.7% suggests a high risk of developing peri-implantitis. CONCLUSION: The concentration of cathepsin K may be seen as valuable marker for local inflammatory and destructive processes in the contents of the peri-implantation area.

Prognostic Risk Models for the Development of Cardiovascular Dysfunction in Adolescents with Essential Hypertension.

We present prognostic risk models for structural and functional cardiovascular disorders in Caucasian adolescents (Russians) with essential hypertension aged 14-17 years (15.92±1.12) taking into account biochemical (catecholamines and cortisol) and genetic parameters (carriage of polymorphic variants of α2A-adrenergic receptor gene ARA2A (-1291С>G), norepinephrine transporter NET (-1287G>A), and D2-dopamine receptor DRD2 (-141C Ins/Del) and the data of psychological testing. Prognostically significant risk factors for increased specific peripheral vascular resistance and variability of daytime systolic BP were a combination of [CC+AA] genotypes of ADRA2A -1291C>G and NET -1287G>A polymorphisms, cortisol level, anxiety, and proneness to conflict. The combination of genotypes [CC+GG+II] of polymorphisms -1291C>G ADRA2A, -1287G>A NET and -141C Ins/Del DRD is prognostically significant, with the GG genotype NET being epistatic.

Redox status as a metabolic stage, integrating emotional pattern and blood pressure in adolescents.

Investigation of emotional sphere and LPO processes in adolescents of both sexes aged 14-17 years suffering from essential hypertension revealed pronounced changes in the emotional status associated with dysregulation in the LPO-antioxidant protection system. The emotional sphere in adolescents with hypertension was characterized by increased anxiety in combination with emotional lability, tendency to depression, and aggressive reactions. The most meaningful parameters describing significant differences between the groups of healthy and hypertensive patients in parameters of LPO-antioxidant protection system were fatty acids with double bonds, antioxidant activity, and retinol. Statistically significant opposite correlations between the emotional status parameters and components of LPO-antioxidant protection system were revealed.

[Peculiarities of functional hemispheric asymmetry formation in children and adolescents with hypertension].

OBJECTIVE: Peculiarities and age dynamics of hemispheric asymmetry investigation in children and adolescents with hypertension. METHODS: 196 children and adolescents aged 10 to 17 years (15.0-1.4), including 98 patients with arterial hypertension (AH) (15.1 ± 1.5) and 98 healthy children of the control group (14.9 ± 1.3). The number of boys in the comparison group and the main group of patients with AH was 60 (61.2%) and 59 (60.2%), girls--38 (38.8%) and 39 (39.8%), respectively. RESULTS: The majority of children and adolescents with hypertension sensorimotor asymmetry differed by low intensity, indicating a decline in the dominance of the left hemisphere. Accumulation of ambi- and left lateral features traced mainly in motor (53.6%) and auditory (60.2%) system, while asymmetry in the visual analyzer did not differ from the control group. Differences in the degree of hemispheric asymmetry increases in the ontogeny compared to control group. CONCLUSION: Identification of specificity hemispheric interaction in patients with hypertension (low asymmetry and its weak performance in ontogeny) can be considered not only as a pathological consequence of hypertension, but also as a compensatory mechanism for the redistribution of loads to the right hemisphere in terms of the functional deficit of the left hemisphere. It can be assumed that the rearparts of the brain may play a significant role in the processes of adaptation and compensation of occurring disorders in hypertension.