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1.
Fetal Diagn Ther ; 47(9): 675-681, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32516788

RESUMO

INTRODUCTION: Bilateral renal agenesis (BRA) is a lethal diagnosis, specifically meaning that natural survival beyond birth is not expected secondary to pulmonary hypoplasia. Limited contemporary data are available about intervention and the impact of restoring amniotic fluid volume in relation to the risk for lethal pulmonary hypoplasia and other factors that might influence survival in cases of fetal BRA. OBJECTIVE: We report the largest series of patients undergoing fetal intervention and postnatal care for BRA at a single comprehensive fetal center. METHODS: All patients with fetal BRA were reviewed from January 2004 to November 2017. Maternal and neonatal data were collected in an institutional review board-approved retrospective review. RESULTS: From 2014 to 2017, 20 singleton pregnancies with isolated fetal BRA were evaluated and 14 had amnioinfusion. Eight had serial infusions. Of those, there were 6 neonatal deaths. There were 2 neonatal survivors beyond 30 days; however, both died of sepsis on dialysis. One of these survivors received amnioinfusions by percutaneous approach and one via amnioport. There were no survivors to transplantation. CONCLUSION: Fetal intervention via amnioinfusion may promote pulmonary survivorship after birth, but postnatal survival remains poor. Future studies must place an emphasis on standardizing the postnatal approach to this patient population.


Assuntos
Anormalidades Congênitas/terapia , Parto Obstétrico , Terapias Fetais/métodos , Nefropatias/congênito , Rim/anormalidades , Adulto , Feminino , Humanos , Recém-Nascido , Nefropatias/terapia , Masculino , Gravidez , Estudos Retrospectivos
2.
J Pediatr Surg ; 54(6): 1153-1158, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30890267

RESUMO

PURPOSE: Congenital high airway obstruction syndrome (CHAOS) is a devastating fetal condition of complete airway discontinuity resulting in significant hydrops and extreme lung hyperplasia. It is universally fatal with survival reported only in the rare spontaneous fistulization or EXIT intervention (Ex Utero Intrapartum Treatment). Even in these cases, mortality remains high, and current investigations are targeting prenatal interventions. This report describes our experience with management and fetal interventions for CHAOS, including laser laryngotomy. METHODS: We retrospectively reviewed all patients diagnosed with CHAOS at a single academic institution between 2006 and 2017. RESULTS: Fifteen patients were identified. Eight had obstruction at the trachea and seven at the larynx. In the laryngeal obstructions, three expired shortly after birth, and one survived after spontaneous fistulization and subsequent EXIT to tracheostomy. The remaining three underwent in-utero treatment with laser laryngotomy. One had preterm premature rupture of membranes (PPROM), delivered 3 days post-operatively, and died. Two underwent EXIT to tracheostomy with one surviving to discharge and is currently 2 years old. CONCLUSION: Our study demonstrates the outcomes of a large series of patients diagnosed with CHAOS. While mortality remains high, options for fetal intervention are being explored to allow alterations in the prenatal natural history and improve postnatal outcomes. TYPE OF STUDY: Retrospective Treatment Study. LEVEL OF EVIDENCE: Level IV.


Assuntos
Obstrução das Vias Respiratórias , Doenças Fetais , Obstrução das Vias Respiratórias/diagnóstico , Obstrução das Vias Respiratórias/terapia , Feminino , Doenças Fetais/diagnóstico , Doenças Fetais/terapia , Humanos , Gravidez , Cuidado Pré-Natal , Estudos Retrospectivos , Síndrome , Traqueostomia
3.
Fetal Diagn Ther ; 45(2): 125-130, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-29791899

RESUMO

BACKGROUND: Gastroschisis is an abdominal wall defect with increasing incidence. Given the lack of surveillance guidelines among maternal-fetal medicine (MFM) specialists, this study describes current practices in gastroschisis management. MATERIALS AND METHODS: An online survey was administered to MFM specialists from institutions affiliated with the North American Fetal Therapy Network (NAFTNet). Questions focused on surveillance timing, testing, findings that changed clinical management, and delivery plan. RESULTS: Responses were obtained from 29/29 (100%) NAFTNet centers, comprising 143/371 (39%) providers. The majority had a regimen for antenatal surveillance in patients with stable gastroschisis (94%; 134/141). Antenatal testing began at 32 weeks for 68% (89/131) of MFM specialists. The nonstress test (55%; 72/129), biophysical profile (50%; 63/126), and amniotic fluid index (64%; 84/131) were used weekly. Estimated fetal weight (EFW) was performed monthly by 79% (103/131) of providers. At 28 weeks, abnormal EFW (77%; 97/126) and Doppler ultrasound (78%; 99/127) most frequently altered management. In stable gastroschisis, 43% (60/140) of providers delivered at 37 weeks, and 29% (40/ 140) at 39 weeks. DISCUSSION: Gastroschisis management differs among NAFTNet centers, although the majority initiate surveillance at 32 weeks. Timing of delivery still requires consensus. Prospective studies are necessary to further optimize practice guidelines and patient care.


Assuntos
Gastrosquise/diagnóstico por imagem , Complicações na Gravidez/diagnóstico por imagem , Adulto , Líquido Amniótico , Parto Obstétrico/métodos , Feminino , Gastrosquise/terapia , Idade Gestacional , Humanos , Recém-Nascido , Gravidez , Complicações na Gravidez/terapia , Diagnóstico Pré-Natal , Resultado do Tratamento , Ultrassonografia Pré-Natal
4.
Obstet Gynecol ; 131(1): 130-134, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-29215523

RESUMO

Congenital bilateral renal agenesis has been considered a uniformly fatal condition. However, the report of using serial amnioinfusions followed by the live birth in 2012 and ongoing survival of a child with bilateral renal agenesis has generated hope, but also considerable controversy over an array of complex clinical and ethical concerns. To assess the ethical concerns associated with using serial amnioinfusions for bilateral renal agenesis, we assembled a multidisciplinary group to map the ethical issues relevant to this novel intervention. The key ethical issues identified were related to 1) potential risks and benefits, 2) clinical care compared with innovation compared with research, 3) counseling of expectant parents, 4) consent, 5) outcome measures, 6) access and justice, 7) conflicts of interest, 8) effects on clinicians, 9) effects on institutions, and 10) long-term societal implications. These ethical issues should be addressed in conjunction with systematic efforts to examine whether this intervention is safe and effective. Future work should capture the experiences of expectant parents, women who undergo serial amnioinfusions, those born with bilateral renal agenesis and their families as well as clinicians confronted with making difficult choices related to it.


Assuntos
Âmnio , Anormalidades Congênitas/diagnóstico por imagem , Anormalidades Congênitas/terapia , Infusões Intralesionais/ética , Nefropatias/congênito , Rim/anormalidades , Oligo-Hidrâmnio/terapia , Resultado da Gravidez , Feminino , Doenças Fetais/diagnóstico por imagem , Doenças Fetais/terapia , Humanos , Consentimento Livre e Esclarecido , Rim/diagnóstico por imagem , Nefropatias/diagnóstico por imagem , Nefropatias/terapia , Saúde Materna , Oligo-Hidrâmnio/diagnóstico por imagem , Gravidez , Medição de Risco , Ultrassonografia Pré-Natal/métodos
5.
Fetal Diagn Ther ; 44(1): 10-17, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-28700992

RESUMO

OBJECTIVE: The aim of this study was to define the natural history of lower urinary tract obstruction (LUTO) with normal midgestational amniotic fluid volumes. MATERIALS AND METHODS: We performed a retrospective review of 32 consecutive patients with LUTO with normal midgestational amniotic fluid volume followed at 11 North American Fetal Therapy Network (NAFTNet) centers from August 2007 to May 2012. Normal amniotic fluid volume was defined as an amniotic fluid index (AFI) of ≥9 cm. RESULTS: The mean gestational age (GA) and AFI at enrollment were 23.1 ± 2.1 weeks and 15.8 ± 3.9 cm, respectively. The mean GA at delivery was 37.3 ± 2.8 weeks. The mean creatinine level at discharge was 1.2 ± 0.8 mg/dL. Perinatal survival was 97%. Twenty-five patients returned for serial postnatal assessment. Renal replacement therapy (RRT) was required in 32%. Development of oligohydramnios and/or anhydramnios, development of cortical renal cysts, posterior urethral valves, prematurity, and prolonged neonatal intensive care unit stay were associated with need for RRT (p < 0.05) by univariate analysis. By multivariate analysis, preterm delivery remained predictive of need for RRT (p = 0.004). CONCLUSION: Prenatal diagnosis of LUTO with normal midgestational amniotic fluid volumes is associated with acceptable renal function in the majority of patients. Approximately one-third of these children require RRT. Surrogate markers of disease severity appear to be predictive of need for RRT.


Assuntos
Obstrução Uretral/epidemiologia , Líquido Amniótico , Feminino , Humanos , Recém-Nascido , Masculino , América do Norte/epidemiologia , Gravidez , Sistema de Registros , Estudos Retrospectivos , Ultrassonografia Pré-Natal , Obstrução Uretral/diagnóstico por imagem
7.
Fetal Diagn Ther ; 41(1): 51-57, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-27287190

RESUMO

OBJECTIVE: We describe a technique to maintain amniotic fluid in fetuses with severe oligo-/anhydramnios secondary to lower urinary tract obstruction or fetal renal disease when urine production is inadequate to maintain a normal amniotic fluid volume (AFV). METHODS: An amnioport was inserted into the amniotic space. The catheter was secured to prevent dislodgment and tunneled to a subcutaneous reservoir. The reservoir was accessed as necessary, infusing normal saline to maintain AFV. Pregnancy continued until term or indicated delivery. RESULTS: Since 2010, 15 patients in this category were considered for an amnioport. Six chose comfort care and one elected percutaneous amnioinfusions. Nine amnioport procedures were performed in eight patients. There were no fetal deaths. All eight had successful restoration and maintenance of amniotic fluid. Delivery ranged from 9 to 96 days after placement (mean 63.7 days). One died due to unrecognized laryngeal web and another one died of pulmonary hypoplasia after preterm premature rupture of membranes. None of the remaining six had pulmonary hypoplasia. Three remain alive. DISCUSSION: Severe oligo-/anhydramnios in the second trimester secondary to fetal anomalies is almost uniformly lethal due to pulmonary hypoplasia without restoration of amniotic fluid. The amnioport procedure may allow pulmonary survival but commits families to postnatal care decisions regarding pulmonary and renal complications.


Assuntos
Cateterismo/métodos , Oligo-Hidrâmnio/terapia , Doenças Urológicas/complicações , Feminino , Humanos , Oligo-Hidrâmnio/diagnóstico por imagem , Gravidez , Resultado do Tratamento , Doenças Urológicas/diagnóstico por imagem , Doenças Urológicas/terapia
8.
Obstet Gynecol ; 128(6): 1340-1346, 2016 12.
Artigo em Inglês | MEDLINE | ID: mdl-27824757

RESUMO

OBJECTIVE: To estimate the accuracy of a new assay to determine the fetal RHD status using circulating cell-free DNA. METHODS: This was a prospective, observational study. Maternal blood samples were collected in each trimester of pregnancy in 520 nonalloimmunized RhD-negative patients. Plasma samples were analyzed for circulating cell-free DNA using the SensiGENE RHD test, which used primers for exons 4 and 7 as previously described and incorporated a new primer design for exon 5 of the RHD gene. Neonatal serology for RhD typing using cord blood at birth was undertaken and results were stored in a separate clinical database. After unblinding the data, results of the DNA analysis were compared with the neonatal serology. RESULTS: Inconclusive results secondary to the presence of the RHD pseudogene or an RHD variant were noted in 5.6%, 5.7%, and 6.1% of the first-, second-, and third-trimester samples, respectively. The incidence of false-positive rates for RhD (an RhD-negative fetus with an RHD-positive result) was 1.54% (95% confidence interval [CI] 0.42-5.44%), 1.53% (CI 0.42-5.40%), and 0.82% (CI 0.04-4.50%), respectively. There was only one false-negative diagnosis (an RhD-positive fetus with an RHD-negative result), which occurred in the first trimester (0.32%; 95% CI 0.08-1.78%). Genotyping for mismatches across repeated samples revealed that this error was related to mislabeling of samples from two patients collected on the same day at one of the collection sites. Overall test results were in agreement across all three trimesters (P>.99). CONCLUSION: Circulating cell-free DNA can accurately predict the fetal RhD status in all three trimesters of pregnancy.


Assuntos
DNA/sangue , Trimestres da Gravidez/sangue , Sistema do Grupo Sanguíneo Rh-Hr/genética , Adulto , Incompatibilidade de Grupos Sanguíneos/sangue , Incompatibilidade de Grupos Sanguíneos/diagnóstico , Sistema Livre de Células , Reações Falso-Negativas , Reações Falso-Positivas , Feminino , Genótipo , Técnicas de Genotipagem , Humanos , Recém-Nascido , Gravidez , Diagnóstico Pré-Natal , Estudos Prospectivos , Imunoglobulina rho(D)/sangue
9.
Placenta ; 36(10): 1078-86, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-26278057

RESUMO

INTRODUCTION: Hypoplastic left heart syndrome (HLHS) is a severe cardiovascular malformation (CVM) associated with fetal growth abnormalities. Genetic and environmental factors have been identified that contribute to pathogenesis, but the role of the placenta is unknown. The purpose of this study was to systematically examine the placenta in HLHS with and without growth abnormalities. METHODS: HLHS term singleton births were identified from a larger cohort when placenta tissue was available. Clinical data were collected from maternal and neonatal medical records, including anthropometrics and placental pathology reports. Placental tissues from cases and controls were analyzed to assess parenchymal morphology, vascular architecture and leptin signaling. RESULTS: HLHS cases (n = 16) and gestational age-matched controls (n = 18) were analyzed. Among cases, the average birth weight was 2993 g, including 31% that were small for gestational age. When compared with controls, gross pathology of HLHS cases demonstrated significantly reduced placental weight and increased fibrin deposition, while micropathology showed increased syncytial nuclear aggregates, decreased terminal villi, reduced vasculature and increased leptin expression in syncytiotrophoblast and endothelial cells. DISCUSSION: Placentas from pregnancies complicated by fetal HLHS are characterized by abnormal parenchymal morphology, suggesting immature structure may be due to vascular abnormalities. Increased leptin expression may indicate an attempt to compensate for these vascular abnormalities. Further investigation into the regulation of angiogenesis in the fetus and placenta may elucidate the causes of HLHS and associated growth abnormalities in some cases.


Assuntos
Peso ao Nascer , Síndrome do Coração Esquerdo Hipoplásico/patologia , Leptina/metabolismo , Placenta/patologia , Feminino , Fibrina/metabolismo , Humanos , Síndrome do Coração Esquerdo Hipoplásico/metabolismo , Tamanho do Órgão , Placenta/irrigação sanguínea , Placenta/metabolismo , Fator de Crescimento Placentário , Gravidez , Proteínas da Gravidez/metabolismo , Receptores para Leptina/metabolismo , Estudos Retrospectivos , Fator A de Crescimento do Endotélio Vascular/metabolismo , Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo
11.
Obstet Gynecol ; 125(3): 649-652, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25730229

RESUMO

For conscientious practitioners, innovative medical therapy often occupies an uncomfortable space between formal research and established clinical practice. Newer and more rapid methods of information dissemination increase the risk of advertising unproven therapies. These and other concerns should not stifle medical progress and innovation but require guidelines and boundaries. The problem is not unique to fetal therapy, but rarely do other fields consider the well-being of two individuals at the same time. Herein, the North American Fetal Therapy Network offers expanded guidelines and suggestions regarding medical innovation that are particular to maternal-fetal therapy.


Assuntos
Terapias Fetais , Perinatologia , Terapias em Estudo , Feminino , Humanos , Gravidez , Obstetrícia/tendências , Perinatologia/tendências
12.
J Am Soc Echocardiogr ; 28(5): 533-40, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25577184

RESUMO

BACKGROUND: Indications for intervention in early-stage (Quintero I and II) twin-twin transfusion syndrome (TTTS) are not standardized. Fetal echocardiography can be used to guide the management of early-stage patients. The aim of this study was to identify early cardiovascular findings that may precede progression to overt recipient twin (RT) cardiomyopathy in early-stage TTTS. METHODS: This was a retrospective review of pregnancies evaluated from 2004 to 2010. Subjects were included when initial evaluation identified Quintero I or II TTTS without evidence of "overt" RT cardiomyopathy, defined on the basis of atrioventricular valve regurgitation, ventricular hypertrophy, and abnormal Doppler myocardial performance indices. Patients elected management with observation or amnioreduction. Pregnancies were grouped by whether the RT developed overt cardiomyopathy. Initial values, including myocardial performance index, diastolic filling time corrected for heart rate (Doppler inflow duration/cardiac cycle length), pulsatility indices of the ductus venosus, umbilical artery, and middle cerebral artery, and cerebroplacental ratio (middle cerebral artery PI/umbilical artery PI), were compared. RESULTS: Of 174 pregnancies evaluated with early-stage TTTS, 45 (26%) did not show evidence of RT cardiomyopathy. Follow-up echocardiography identified cardiomyopathy in 20 of 45 RTs (44%). Those RTs with subsequent cardiomyopathy had shorter diastolic filling times corrected for heart rate, higher ductus venosus PIs, lower middle cerebral artery PIs, and lower cerebroplacental ratios on initial echocardiography. CONCLUSION: Diastolic dysfunction and cerebroplacental redistribution precede findings of overt cardiomyopathy in RTs with early-stage TTTS. Assessment of these parameters may allow earlier identification of RTs with cardiac disease and help guide management. Prospective studies are needed to assess the role of echocardiography in patient selection for the treatment of early-stage TTTS.


Assuntos
Cardiomiopatias/embriologia , Circulação Cerebrovascular/fisiologia , Ecocardiografia Doppler , Doenças Fetais/diagnóstico por imagem , Coração Fetal/diagnóstico por imagem , Transfusão Feto-Fetal/embriologia , Ultrassonografia Pré-Natal/métodos , Adulto , Cardiomiopatias/diagnóstico por imagem , Diástole , Feminino , Doenças Fetais/fisiopatologia , Transfusão Feto-Fetal/diagnóstico por imagem , Transfusão Feto-Fetal/fisiopatologia , Seguimentos , Idade Gestacional , Humanos , Gravidez , Estudos Retrospectivos
13.
J Matern Fetal Neonatal Med ; 28(14): 1647-52, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25248665

RESUMO

OBJECTIVE: To measure amniotic fluid leptin levels in fetuses with twin-twin transfusion syndrome (TTTS) with and without placental insufficiency (PI) and determine its usefulness as a biomarker of PI. STUDY DESIGN: A retrospective case control study of TTTS stage III patients from 2009 to 2011 was conducted. Cases were pregnancies with PI (TTTS-PI, n = 18) matched by stage, gestational age, and degree of cardiomyopathy to controls without PI (TTTS, n = 26). PI was strictly defined using biometric parameters. Amniotic fluid from recipient twins (RT) was taken during second trimester fetoscopic laser therapy. Leptin concentrations were determined and compared to growth parameters and birth weight. RESULTS: RT-adjusted leptin was 66% higher in TTTS-PI (p = 0.016) compared to TTTS controls. Cases had significantly higher growth discordance (p = 0.004) and lower RT birth weight (p = 0.041) compared to controls. Significantly higher adjusted leptin levels were observed at birth in the TTTS-PI group when comparing those with SGA donor twins to those of normal weight (p = 0.016). CONCLUSION: These data suggest a role for leptin in pregnancies complicated by TTTS with placental insufficiency. However, further studies are needed to define its mechanism and potential role as a biomarker in amniotic fluid for placental pathophysiology.


Assuntos
Líquido Amniótico/metabolismo , Transfusão Feto-Fetal/complicações , Leptina/metabolismo , Insuficiência Placentária/diagnóstico , Adulto , Biomarcadores/metabolismo , Estudos de Casos e Controles , Feminino , Transfusão Feto-Fetal/metabolismo , Humanos , Insuficiência Placentária/metabolismo , Gravidez , Segundo Trimestre da Gravidez , Estudos Retrospectivos
14.
Fetal Diagn Ther ; 37(1): 18-23, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25195565

RESUMO

OBJECTIVE: To evaluate the intrauterine management and perinatal outcome of pregnancies complicated by giant placental chorioangioma (>4 cm) and elaborate on various devascularization techniques. MATERIALS AND METHODS: Retrospective review of 10 cases of giant placental chorioangioma evaluated between January 2005 and August 2012. Maternal demographics, prenatal imaging, response to fetoscopic treatment, obstetrical complications, and perinatal outcomes were evaluated. RESULTS: Overall survival was 80%. Seven (70%) cases were associated with obstetrical complications, including polyhydramnios (n = 7), non-immune hydrops (n = 3), and high cardiac output state (n = 5). Five patients underwent fetoscopic devascularization at a mean gestational age of 24.03 weeks with 80% survival. The tumors were devascularized by bipolar coagulation (n = 1), combination of bipolar and diode laser (n = 2), bipolar and radiofrequency ablation (n = 1), and surgical clip application (n = 1). Postoperatively, all survivors had resolution of hydrops and high cardiac output states with survival beyond 60 days of life. DISCUSSION: Fetoscopic devascularization is indicated for high cardiac output states or non-immune hydrops and may require multiple techniques including bipolar coagulation, clip application, and/or laser to interrupt arterial inflow and devascularize the mass.


Assuntos
Fetoscopia/métodos , Hemangioma/cirurgia , Doenças Placentárias/cirurgia , Complicações Neoplásicas na Gravidez/cirurgia , Adulto , Feminino , Idade Gestacional , Hemangioma/diagnóstico por imagem , Humanos , Doenças Placentárias/diagnóstico por imagem , Gravidez , Complicações Neoplásicas na Gravidez/diagnóstico por imagem , Resultado da Gravidez , Estudos Retrospectivos , Ultrassonografia Pré-Natal
15.
Ophthalmology ; 121(6): 1312-3, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24529712
16.
Pediatr Radiol ; 43(10): 1385-90, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-23567909

RESUMO

Tracheal agenesis is a rare and essentially lethal anomaly with divergent prenatal imaging findings depending on the presence or absence of a tracheoesophageal fistula. All prenatally diagnosed cases of tracheal agenesis reported to date have not had a tracheoesophageal fistula and presented with thoracoabdominal findings similar to congenital high airway obstruction syndrome. We present the case of a 32-week gestation fetus with rapid onset of polyhydramnios and no persistent findings of congenital high airway obstruction syndrome that was ultimately diagnosed with tracheal agenesis plus tracheoesophageal fistula by fetal MRI. Additionally, we present the novel uses of intraoperative US during a staged ex utero intrapartum therapy delivery and postdelivery MRI, facilitated by proximity within the neonatal ICU, to confirm diagnosis and direct patient management while minimizing unnecessary investigations.


Assuntos
Constrição Patológica/embriologia , Constrição Patológica/patologia , Imageamento por Ressonância Magnética/métodos , Traqueia/anormalidades , Fístula Traqueoesofágica/embriologia , Fístula Traqueoesofágica/patologia , Ultrassonografia Pré-Natal/métodos , Constrição Patológica/cirurgia , Parto Obstétrico/métodos , Humanos , Recém-Nascido , Masculino , Traqueia/embriologia , Traqueia/patologia , Traqueia/cirurgia , Fístula Traqueoesofágica/cirurgia
17.
Am J Obstet Gynecol ; 203(4): 397.e1-9, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-20723877

RESUMO

OBJECTIVE: The purpose of this study was to evaluate the effect of maternal nifedipine on fetal survival when started 24-48 hours before selective fetoscopic laser photocoagulation (SFLP). STUDY DESIGN: We conducted a case control study of consecutive cases of twin-twin transfusion syndrome (TTTS) in which TTTS cardiomyopathy was treated with maternal nifedipine 24-48 hours before SFLP, compared with gestational age and stage-matched control cases. The primary outcome was recipient and donor survival. RESULTS: One hundred forty-one cases of TTTS were treated with nifedipine, and 152 gestational age- and stage-matched control cases were analyzed. There was a significant increase in overall fetal survival in nifedipine-treated cases compared with control cases (237/284 [83%] vs 232/308 [75%]; P = .015). There is an increase in survival of recipients who were treated with nifedipine in stage IIIA (100% vs 81%; P = .021) and IIIB (93% vs 71%; P = .014); however, there was no difference in donor survival. CONCLUSION: Maternal nifedipine is associated with improved recipient survival in TTTS that undergoes SFLP. This is the first study to suggest a benefit of adjunctive maternal medical therapy in patients with TTTS who undergo SFLP.


Assuntos
Cardiomiopatias/tratamento farmacológico , Transfusão Feto-Fetal/mortalidade , Transfusão Feto-Fetal/cirurgia , Nifedipino/uso terapêutico , Vasodilatadores/uso terapêutico , Cardiomiopatias/diagnóstico , Estudos de Casos e Controles , Feminino , Fetoscopia , Humanos , Fotocoagulação a Laser , Gravidez , Índice de Gravidade de Doença , Análise de Sobrevida , Ultrassonografia Pré-Natal
18.
Am J Obstet Gynecol ; 203(4): 404.e1-7, 2010 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-20719292

RESUMO

OBJECTIVE: We sought to evaluate amniotic fluid brain natriuretic peptide (BNP) levels as a biomarker of recipient twin (RT) cardiomyopathy (RTCM) in twin-twin transfusion syndrome. STUDY DESIGN: Amniotic fluid samples were obtained from 157 twin-twin transfusion syndrome RTs and from 6 singletons (controls) from 2007 through 2009. N-terminal prohormone BNP (NT-proBNP) levels were quantified by enzyme-linked immunosorbent assay. RTCM was classified as mild (IIIA), moderate (IIIB), or severe (IIIC) by fetal echocardiography. The relationship between NT-proBNP and RTCM was evaluated using analysis of variance. The ability of NT-proBNP to predict moderate or greater RTCM was evaluated by receiver operating characteristic analysis. RESULTS: There is a significant positive correlation between NT-proBNP levels and worsening RTCM (r = 0.33; P < .001). NT-proBNP thresholds of 569 fmol/mg and 369 fmol/mg had a sensitivity of 70% and 87%, and specificity of 67% and 42%, respectively, in predicting moderate or greater RTCM. CONCLUSION: This is the first large case series that demonstrates a relationship between NT-proBNP and RTCM. This pathophysiologic insight supports ongoing efforts to develop screening biomarkers.


Assuntos
Líquido Amniótico/metabolismo , Cardiomiopatias/metabolismo , Transfusão Feto-Fetal/metabolismo , Peptídeo Natriurético Encefálico/metabolismo , Fragmentos de Peptídeos/metabolismo , Adulto , Biomarcadores/metabolismo , Velocidade do Fluxo Sanguíneo , Cardiomiopatias/diagnóstico por imagem , Estudos de Casos e Controles , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Gravidez , Curva ROC , Estudos Retrospectivos , Sensibilidade e Especificidade , Índice de Gravidade de Doença , Ultrassonografia Doppler , Veias Umbilicais/diagnóstico por imagem
19.
Fetal Diagn Ther ; 26(2): 93-7, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19816035

RESUMO

Congenital high airway obstruction syndrome (CHAOS) is a life-threatening condition characterized by complete blockage of the fetal airways associated with hydrops. We present a case of CHAOS due to the rare cause of complete tracheal agenesis. The ex utero intrapartum therapy (EXIT) strategy was employed to allow for neck and mediastinal exploration. Thymectomy allowed dissection to the level of the carina demonstrating the confluence of dilated mainstem bronchi but no trachea and no connection to the esophagus. A 2.5 endotracheal tube was inserted into the right mainstem bronchus and secured to the left clavicle. At 3 months of age, the infant succumbed to sepsis from Enterobacter mediastinitis due to friction between the tracheostomy tube and the nasogastric tube resulting in erosion of the esophagus. Complete tracheal agenesis, as seen in this case, is consistent with the failure of normal tracheal elongation as suggested by newer theories of foregut development. This case illustrates the most severe form of tracheal atresia causing CHAOS ever salvaged by the EXIT procedure at birth. The subsequent postnatal course highlights the need for early tracheal replacement in this particularly challenging form of CHAOS.


Assuntos
Obstrução das Vias Respiratórias/diagnóstico por imagem , Traqueia/embriologia , Doenças da Traqueia/diagnóstico por imagem , Adulto , Obstrução das Vias Respiratórias/congênito , Obstrução das Vias Respiratórias/embriologia , Obstrução das Vias Respiratórias/cirurgia , Feminino , Humanos , Imageamento por Ressonância Magnética , Gravidez , Doenças da Traqueia/congênito , Doenças da Traqueia/embriologia , Doenças da Traqueia/cirurgia , Traqueostomia , Ultrassonografia Pré-Natal
20.
Am J Obstet Gynecol ; 201(4): 417.e1-7, 2009 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-19788973

RESUMO

OBJECTIVE: The purpose of this study was to evaluate the incidence of complications after selective fetoscopic laser photocoagulation for twin-twin transfusion syndrome (TTTS). STUDY DESIGN: One hundred fifty-two cases of TTTS were treated with selective fetoscopic laser photocoagulation from 2005-2008. Complications were TTTS recurrence, amniotic band syndrome, iatrogenic monoamnionicity, and twin anemia-polycythemia sequence. Data were placed in the following categories: no complications; early complications < or =7 days; late complications >7 days; both early and late complications. RESULTS: The incidence of early, late, and both early and late complications was 31%, 39%, and 10%. Complications included 2 cases (1.3%) of monoamnionicity, 3 cases (2.0%) of recurrent TTTS, 3 cases (2.0%) of twin anemia-polycythemia sequence, and 5 cases (3.3%) of amniotic band syndrome. Cases with TTTS with early complications had a lower number of superficial arteriovenous vascular anastomoses and 1 or both fetus survival (70.2% vs 96.7%; P < .001), compared with no complications. Fetal survival was 238 of 307 cases (77.5%), with 1 or both twins surviving in 134 of 152 (88%) of pregnancies. CONCLUSION: The incidence of early, late, and both early and late complications was 31%, 39%, and 10%, respectively. Close postoperative surveillance is important.


Assuntos
Transfusão Feto-Fetal/complicações , Transfusão Feto-Fetal/cirurgia , Fetoscopia , Fotocoagulação a Laser , Síndrome de Bandas Amnióticas/epidemiologia , Feminino , Humanos , Incidência , Recém-Nascido , Policitemia/epidemiologia , Gravidez , Recidiva
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