[Normal polymorphism of the (CTG)n repeat in the myotonin protein kinase (DM) gene on chromosome 19q13.3 in Western European populations]. / Normal'nyi polimorfizm povtora (CTG)n v gene miotoninproteinkinazy (DM) na khromosome 19q13.3 v populiatsiiakh vostochnoi evropy.

Polymorphism of a highly polymorphic CTG repeat in the 3'-untranslated region of the myotonin protein kinase gene was analyzed in healthy people from several Eastern European populations (Russians, Moldovans, Belarussians, Komis, Chuvashes, Udmurts, Bashkirs, Tatars, Maris, and Mordovians). In total, 26 alleles of the CTG repeat were found, the repeat number ranging from 5 to 33 (alleles with six and seven repeats were not detected). The heterozygosity of individual populations varied from 61 to 91%. In the total sample combining all populations, the observed and expected heterozygosities did not differ (fixation index -0.0022) suggesting selective neutrality of the normal polymorphism of the CTG repeat in the myotonin protein kinase gene.

[Polymorphism of the (CTG)n repeat in the myotonin protein kinase (DM) gene in Belarussian populations: analysis of interethnic heterogeneity]. / Polimorfizm povtora (CTG)n v gene miotoninproteinkinazy (DM) v populiatsiiakh belorusov: analiz vnutriétnicheskoi geterogennosti.

The highly polymorphic CTG triplet repeat in the 3'-nontranscribed region of the myotonin protein kinase (DM) gene was studied in healthy people from three rural populations (Grodnenskii, Khoinikskii, and Nesvizhskii raions) and the town Bobruisk, Belarus. The allele frequency distribution of this repeat proved to be similar in all the regional groups of Belarussians.