[Hemosorption in status epilepticus and serial epileptic seizures]. / Gemosorbtsiia pri épilepticheskom statuse i seriinykh épilepticheskikh pripadkakh.

Hemosorption was performed in 8 patients with a resistant status epilepticus and serial epileptic attacks; arrest of the attacks correlated with significantly faster and stabler normalization of the circulating levels of immune complexes and of the phagocytic activity of neutrophils as compared to the same parameters in patients receiving a course of conventional anticonvulsive and dehydration therapy without hemosorption. The data obtained point to the advisability of the inclusion of hemosorption into a multiple modality treatment of patients with a persistent grand mal status and serial epileptic attacks. High circulating levels of immune complexes in the blood serum may be considered as indication for hemosorption.

[Concentration of circulating immune complexes in the blood in clinical and experimental epileptic seizures]. / Soderzhanie tsirkuliruiushchikh immunnykh kompleksov v krovi pri épilepticheskikh pripadkakh v klinike i éksperimente.

The levels of circulating immune complexes (CIC) in the peripheral blood were studied in 31 epileptic patients and 30 rabbits which served as an experimental model of the development of the epileptic process. CIC levels in the blood serum were measured by means of polyethylene glycol precipitation followed by measurement of optic density by a spectrophotometer. Elevated concentrations of CIC in the patients' blood were observed in the period of the epileptic status and during a series of epileptic attacks, as well as in experimental animal during epileptic attacks and in the period preceding their development. Blood analysis made at different periods after controlling the attacks showed gradual normalization of the levels of CIC. The role of CIC in the development and maintenance of epileptic seizures is discussed.

[Immunoenzyme analysis of the antigenic orientation of "anti-brain" autoantibodies in the serum of epileptics]. / Immunofermentnyi analiz antigennoi napravlennosti "antimozgovykh" avtoantitel syvorotki krovi bol'nykh épilepsiei.

With the help of a solid-phase ELISA and the test system of rat brain antigens (protein fractions divided by isoelectrofocusing into zones differing in pI values) the authors discovered autoantibodies to species-nonspecific protein antigens of the brain in the blood sera of epileptic patients and obtained data on the spectra of the antigenic orientation of these autoantibodies. It has been noted that the epileptics' blood sera are characterized by high titres of autoantibodies to glial brain-specific proteins of the group S-100, as well as by undifferentiated proteins, with pI values 3-3.5 and 5-5.5. There were no significant differences in the spectra of the antigenic orientation of autoantibodies in patients with different frequencies of seizures and the localization of the epileptic focus. Considerable differences in the orientation of cerebral autoantibodies in patients with different disease standing were discovered.