RESUMO
BACKGROUND/AIMS: The aim of this study was to evaluate macroscopic and histologic disorders of the colon in rats with portal hypertension. METHODOLOGY: The animals were divided into two groups: 10 rats in the experimental group and 10 controls. Portal hypertension was induced by a partial ligation of the portal vein. We assessed the histologic appearance and macroscopic alterations of the colonic mucosa 12 weeks after the induction of portal hypertension. RESULTS: The macroscopic results showed the presence of the typical signs of portal hypertension, with dilatation and tortuosity of the mesenteric veins and hyperemia of the rectum and colon. Histologic study revealed a marked dilatation in the microcirculation at the level of the ascending colon (20 +/- 2 micra in diameter) and rectum (30 +/- 4), with a tendency to group the lesions. Submucosal edema without inflammatory signs was observed. CONCLUSION: The existence of these lesions in the colon and rectum can be the cause of hemorrhage, as in the gastropathy of portal hypertension and should be considered in cases of undiagnosed hemorrhage in patients with portal hypertension.
Assuntos
Colo/patologia , Doenças do Colo/patologia , Hipertensão Portal/complicações , Mucosa Intestinal/patologia , Animais , Colo/irrigação sanguínea , Doenças do Colo/etiologia , Feminino , Hemorragia Gastrointestinal/etiologia , Hemorragia Gastrointestinal/patologia , Hipertensão Portal/patologia , Mucosa Intestinal/irrigação sanguínea , Microcirculação/patologia , Ratos , Ratos Wistar , Reto/irrigação sanguínea , Reto/patologiaRESUMO
Four cases are reported of upper gastrointestinal hemorrhage caused by Dieulafoy's vascular disease treated in our service over the last 15 years. In all these patients bleeding was from an unusually long artery with a tortuous trajectory through the gastric submucosa that eroded the mucosa and caused blood loss. In 75% of the cases it was located 6 cm below the gastroesophageal junction, near the small curvature. The diagnosis is usually made by endoscopy or during emergency gastrostomy. The most effective therapeutic measure is surgical resection.
Assuntos
Malformações Arteriovenosas/complicações , Mucosa Gástrica/irrigação sanguínea , Hemorragia Gastrointestinal/etiologia , Gastropatias/etiologia , Adulto , Artérias , Malformações Arteriovenosas/patologia , Feminino , Mucosa Gástrica/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos RetrospectivosRESUMO
Angiodysplasia, a recently discovered disease, is a pathology of scant incidence in our environment and difficult to find because of the inconclusiveness of diagnostic proofs. The disease, generally related to adults and the elderly, and preferentially located in the large intestine, does not always manifest this way. The case we present is one of the youngest in the world literature and of ectopic localization in the terminal ileum. This confirms the enigmatic aspect of this pathology, which still has characteristics to be delimited. Its etiology, incidence and prevalence are unknown and there are no unanimous criteria for its classification or possible association with other pathologies.
