RESUMO
Ciprofloxacin resistance was identified in 18% and 6% of consecutively collected, clinically significant urinary tract isolates of Escherichia coli from inpatients and outpatients, respectively. In comparison to ciprofloxacin-susceptible isolates, there were fewer resistant isolates that expressed beta-hemolysis (outpatient, 9% versus 87%, P < 0.0001; inpatient, 4% versus 76%, P < 0.0001) and that had a papEF genotype, genes encoding P fimbriae (outpatient, 30% versus 70%, P = 0.0004; inpatient, 26% versus 70%, P < 0.0001).
Assuntos
Bacteriúria/microbiologia , Ciprofloxacina/farmacologia , Escherichia coli/efeitos dos fármacos , Escherichia coli/patogenicidade , Fatores de Virulência/análise , Farmacorresistência Bacteriana , Hemólise , Humanos , Ácido Nalidíxico/farmacologiaRESUMO
The in vitro activity of BMS-284756 against 602 Staphylococcus aureus isolates, including 152 that were both methicillin and ciprofloxacin resistant (MIC > or = 4 microg/ml), was determined. For ciprofloxacin-susceptible and nonsusceptible isolates, the MICs at which 50% of organisms were inhibited were 0.015 and 2 microg/ml and the MICs at which 90% of organisms were inhibited were 0.03 and 4 microg/ml, respectively.
Assuntos
Anti-Infecciosos/farmacologia , Fluoroquinolonas , Indóis , Mutação/genética , Quinolonas , Staphylococcus aureus/efeitos dos fármacos , Staphylococcus aureus/genética , Substituição de Aminoácidos , DNA Girase/genética , DNA Topoisomerase IV/antagonistas & inibidores , DNA Topoisomerase IV/genética , DNA Bacteriano/efeitos dos fármacos , DNA Bacteriano/genética , Resistência Microbiana a Medicamentos , Humanos , Resistência a Meticilina , Testes de Sensibilidade Microbiana , Infecções Estafilocócicas/microbiologia , Inibidores da Topoisomerase IIRESUMO
Among 418 blood culture isolates of viridans group streptococci obtained between 1995 and 1997, the in vitro rates of nonsusceptibility to penicillin, erythromycin, tetracycline, and trimethoprim-sulfamethoxazole were 28, 29, 24, and 14%, respectively. The most prevalent group (125 strains) was Streptococcus mitis, followed by Streptococcus sanguis (56 strains). For 236 (56%) strains resistant to one or more antibiotics, the ciprofloxacin MIC at which 90% of the isolates were inhibited (MIC(90)) was 4 microg/ml, whereas the MIC(90)s of trovafloxacin, grepafloxacin, and gatifloxacin were 0.25 microg/ml.
