RESUMO
Glucoside derivatives, xylarosides A (1) and B (2), were isolated from the broth extract of the endophytic fungus Xylaria sp. PSU-D14 along with two known compounds, sordaricin (3) and 2,3-dihydro-5-hydroxy-2-methyl-4H-1-benzopyran-4-one (4). The structures were assigned by spectroscopic methods. Sordaricin (3), one of the known metabolites, exhibited moderate antifungal activity against Candida albicans ATCC90028 with a MIC value of 32 microg/ml.
Assuntos
Xylariales/metabolismo , Glucosídeos/química , Glucosídeos/metabolismo , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Xylariales/química , Xylariales/classificaçãoRESUMO
Chemical investigation of the wood-decayed fungus Xylaria sp. BCC 9653 has led to the isolation of a new methyl aminobenzoate (1) together with eleven known compounds. The structures were established by analysis of spectroscopic data. Cytochalasin D (2), one of the known metabolites, exhibited potent cytotoxicity against African green monkey kidney fibroblast (Vero) cells with an IC(50) value of 0.19 microM.
Assuntos
Antivirais/farmacologia , Citocalasina D/farmacologia , Fibroblastos/efeitos dos fármacos , Rim/efeitos dos fármacos , Madeira , Xylariales/química , para-Aminobenzoatos , Ácido 4-Aminobenzoico/química , Ácido 4-Aminobenzoico/isolamento & purificação , Ácido 4-Aminobenzoico/farmacologia , Animais , Antivirais/química , Antivirais/isolamento & purificação , Células Cultivadas , Chlorocebus aethiops , Citocalasina D/química , Citocalasina D/isolamento & purificação , Fibroblastos/citologia , Concentração Inibidora 50 , Rim/citologia , Rim/metabolismo , Estrutura Molecular , Análise Espectral , Células Vero/efeitos dos fármacosRESUMO
One new dihydrobenzofuran derivative, botryomaman (1), was isolated from the broth extract of the endophytic fungus Botryosphaeria mamane PSU-M76 along with six known compounds, 2,4-dimethoxy-6-pentylphenol, (R)-(-)-mellein, primin, cis-4-hydroxymellein, trans-4-hydroxymellein and 4,5-dihydroxy-2-hexenoic acid. The structures were assigned by spectroscopic methods. All compounds were tested for antibacterial activity against Staphylococcus aureus ATCC 25923 and methicillin-resistant S. aureus SK1. Primin showed the best activity against both strains with equal MIC values of 8 microg/ml.
Assuntos
Antibacterianos/isolamento & purificação , Antibacterianos/farmacologia , Ascomicetos/química , Benzofuranos/isolamento & purificação , Benzofuranos/farmacologia , Cromatografia em Camada Fina , Fermentação , Espectroscopia de Ressonância Magnética , Resistência a Meticilina , Testes de Sensibilidade Microbiana , Espectrofotometria Ultravioleta , Staphylococcus aureus/efeitos dos fármacosRESUMO
Five new chromones, named lachnones A-E (1-5), were isolated from the filamentous fungus Lachnum sp. BCC 2424 along with known (2E,6S)-2,6-dimethyl-2,7-octadiene-1,6-diol. Their structures were elucidated by spectroscopic methods. Lachnones B (2) and D (4) mildly inhibited the growth of Mycobacterium tuberculosis, both with MIC values of 200 microg/mL.
Assuntos
Antituberculosos/isolamento & purificação , Ascomicetos/química , Cromonas/isolamento & purificação , Mycobacterium tuberculosis/efeitos dos fármacos , Antituberculosos/química , Antituberculosos/farmacologia , Cromonas/química , Cromonas/farmacologia , Testes de Sensibilidade Microbiana , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , TailândiaRESUMO
Tetraoxygenated xanthones, cowaxanthones A-E, together with 10 previously reported tetraoxygenated xanthones, were isolated from the crude hexane extract of the fruits of Garcinia cowa. Cowaxanthone B has previously been reported as a synthetic xanthone. Their structures were elucidated by analysis of spectroscopic data, especially by 1D and 2D NMR. The antibacterial activities of the isolated compounds were also evaluated.
Assuntos
Antibacterianos/química , Frutas/química , Garcinia/química , Xantonas/química , Antibacterianos/isolamento & purificação , Antibacterianos/farmacologia , Resistência a Meticilina , Ressonância Magnética Nuclear Biomolecular , Extratos Vegetais/química , Extratos Vegetais/isolamento & purificação , Extratos Vegetais/farmacologia , Staphylococcus aureus/efeitos dos fármacos , Xantonas/isolamento & purificação , Xantonas/farmacologiaRESUMO
Two pimarane diterpenes, named scopararanes A (1) and B (2), and two cytochalasins, named scoparasins A (3) and B (4), along with 4,8-dihydroxy-6-methoxy-4,5-dimethyl-3-methyleneisochroman-1-one (5) and diaportheins A (6) and B (7) were isolated from a culture broth of the endophytic fungus Eutypella scoparia PSU-D44. Their antimicrobial activities against Staphylococcus aureus ATCC 25923 and Microsporum gypseum SH-MU-4 were examined.
