RESUMO
The changes in body weight after jejuno-ileal bypass surgery in 23 cases of massive obesity are reported. After an initial rapid weight reduction, body weight fell at a constant rate over six months. The weight reduction curves correspond to a zero order kinetics. After the first six months the rate of weight loss declined, but the weight continued to fall. By 12 to 24 months after the operation stabilization of body weight at an average level corresponding to 38% of the preoperative weight was attained.
Assuntos
Peso Corporal , Íleo/cirurgia , Jejuno/cirurgia , Obesidade/terapia , Ingestão de Alimentos , Humanos , Absorção Intestinal , Cinética , Período Pós-OperatórioRESUMO
Six patients subjected to jejuno-ileal bypass surgery for obesity were studied for vitamin B12 absorption by the use of the Schilling test, together with measurement of the serum B12 level preoperatively and at 2, 6, 12, 18 and 24 months after the operation. During the follow-up period of 2 years, the serum vitamin B12 level gradually declined to abnormally low values. A postoperative fall of the originally normal vitamin B12 absorption to abnormal values was found. Oral administration of tetracycline resulted in a transitory improvement of the results by the Schilling test, but after its discontinuation serve vitamin-B12 malabsorption was again demonstrable. The importance of parenteral vitamin B12 administration after jejuno-ileal bypass surgery is emphasized.
Assuntos
Íleo/cirurgia , Jejuno/cirurgia , Síndromes de Malabsorção/etiologia , Obesidade/terapia , Síndrome do Intestino Curto/etiologia , Vitamina B 12/metabolismo , Humanos , Cinética , Complicações Pós-Operatórias/metabolismo , Teste de Schilling , Síndrome do Intestino Curto/metabolismo , Síndrome do Intestino Curto/terapia , Tetraciclina/uso terapêuticoAssuntos
Peso Corporal , Íleo/cirurgia , Jejuno/cirurgia , Obesidade/terapia , Adulto , Humanos , MasculinoRESUMO
A method was developed for the separation by thin-layer chromatography of 14C-labelled 3-methoxy, 4-hydroxyphenethylamine, 3-hydroxy, 4-methoxyphenethylamine and 3,4-dimethoxyphenethylamine (DMPEA) after incubation of dopamine with catechol-O-methyltransferase (COMT) in lysates of human red blood cells (RBC). 14 C-methyl-S-adenosyl-menthionine was used as the methyl donor. Total COMT activity with noradrenaline or dopamine as substrates, respectively, and the pattern of 14C-methylated metabolites of dopamine were measured in RBC of 47 schizophrenic patients and in 34 control subjects. There were no differences between patients and controls. DMPEA was not formed by RBC in schizophrenic patients (or in controls), a finding which argues against the "pnk spot"/DMPEA hypothesis of schizophrenia. The methods used seem suitable for studies of other human disorders where COMT might be involved.
Assuntos
Dopamina/sangue , Eritrócitos/metabolismo , Esquizofrenia/sangue , 5-Metoxitriptamina/sangue , Adolescente , Adulto , Idoso , Catecol O-Metiltransferase/sangue , Dimetoxifeniletilamina/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Exact probability analysis of the spontaneous bursting activity of epileptic units is a common problem. A microcomputer method, suitable for the calculation of the scalar function of two variables of the spike occurrence of this type of discharge, has been developed. The time measured from the first spike of a burst and the duration of the preceding interburst interval were chosen as the variables of the evaluated functions. A typical unit activity was analysed by the program. The method may be useful for the classification of different bursting patterns.
