RESUMO
A Jarvik-7 type of pneumatic artificial heart, which was specifically designed to fit the anatomy and hemodynamic requirements of human patients, was implanted in a calf in an experiment to test the hemodynamic performance of the artificial heart. The experiment lasted for 221 days, longer than any animal had ever lived without its natural heart, despite the fact that the calf increased its body weight to 171 kg. The calf showed typical signs of low cardiac output before its death, but the direct cause of death was intestinal bleeding. At autopsy, it was discovered that the low cardiac output was due to severe pannus around the left inflow valve, as diagnosed earlier by changes in the pneumatic pressure wave form.
Assuntos
Coração Artificial , Procedimentos Cirúrgicos Operatórios/mortalidade , Animais , Débito Cardíaco , Bovinos , Coração/fisiologia , Testes de Função Cardíaca , Frequência Cardíaca , Hemodinâmica , MasculinoRESUMO
The miniature components of an intra-aortic balloon pumping system (IABP) have been successfully developed in this laboratory and have been effectively tested both in vitro and in 32 in vivo experiments using small animals weighing 3.5--18 kg. It is reasonable to assume that IABP can be successfully employed for clinical use in infants and small children.
Assuntos
Circulação Assistida/instrumentação , Cardiopatias Congênitas/terapia , Balão Intra-Aórtico/instrumentação , Animais , Peso Corporal , Gatos , Cães , Cardiopatias Congênitas/fisiopatologia , Hemodinâmica , Humanos , Recém-Nascido , Miniaturização , Modelos BiológicosRESUMO
A pneumatically powered artificial heart, constructed primarily from a polyurethane, was implanted in the chest of a calf and supported the calf for more than 6 months. The heart, which was designed to fit in the chest of a 90 kilogram calf, was able to suppor the animal when it weighed 180 kilograms. During the first 105 days the calf remained strong and healthy. The animal grew progressively weaker after day 106, and by day 160 right heart failure became apparent. The principal cause of the right heart failure was an obstructive growth between the right atrium and the right ventricle. An attempt to correct the problem on day 184 with an artificial heart resulted in the animal's death.
