Assuntos
Humanos , Feminino , Idoso , Carcinoma , Neoplasias Inflamatórias Mamárias , Linfoma não HodgkinRESUMO
The purpose of this report is to describe the unique cytological findings of a new recently characterized type of meningioma that has extensive noncalcifying collagenous whorls and glial fibrillary acid protein (GFAP) expression. This new entity, described by Haberler and colleagues, was named whorling sclerosing variant of meningioma. The patient was a 34-yr-old white man with a large tumor in the brainstem. Intraoperative smear preparations showed a tumor with a large number of solid hyaline masses in a loose background and in focal areas tumor cells formed cohesive nests with a somewhat whorling appearance. The histological sections showed a neoplasia composed of innumerable eosinophilic, collagenous, noncalcified round deposits, cuffed by scattered meningothelial tumor cells. The neoplastic cells showed diffuse cytoplasmic reactivity for EMA and vimentin, as well as positivity to GFAP. This is the first cytological description of this new entity in the literature.
Assuntos
Citodiagnóstico , Proteína Glial Fibrilar Ácida/biossíntese , Neoplasias Meníngeas/patologia , Meningioma/patologia , Adulto , Neoplasias Encefálicas/patologia , Colágeno/ultraestrutura , Diagnóstico Diferencial , Humanos , Imuno-Histoquímica , Imageamento por Ressonância Magnética , Masculino , Neoplasias Meníngeas/metabolismo , Neoplasias Meníngeas/ultraestrutura , Meningioma/metabolismo , Meningioma/ultraestruturaAssuntos
Células Epitelioides/patologia , Neoplasias de Bainha Neural/secundário , Neoplasias de Tecidos Moles/patologia , Adulto , Biomarcadores Tumorais/análise , Evolução Fatal , Humanos , Técnicas Imunoenzimáticas , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/secundário , Imageamento por Ressonância Magnética , Masculino , Proteínas de Neoplasias/análise , Neoplasias de Bainha Neural/química , Neoplasias de Bainha Neural/diagnóstico por imagem , Radiografia Torácica , Neoplasias de Tecidos Moles/química , Neoplasias de Tecidos Moles/diagnóstico por imagem , Tomografia Computadorizada por Raios XRESUMO
Malignant mesothelioma with deciduoid features (MMWDF) is a recently characterized morphologic variant of epithelioid malignant mesothelioma, which frequently is misdiagnosed as peritoneal deciduosis or florid mesothelial hyperplasia. We report on the cytological, histological, immunohistochemical, and autopsy findings of a case of MMWDF arising in the pericardium of a 71-yr-old female patient. Cytology showed large, polygonal to round cells with pale to bright, eosinophilic cytoplasm, occasionally showing xantomatous pattern, containing a pleomorphic and vesicular nucleus with a single prominent nucleolus. Autopsy examination showed a neoplasm encasing the heart and great vessels. No other primary neoplasm was found. The histological analysis disclosed the typical features of MMWDF. Immunohistochemistry showed diffuse immunoreactivity for cytokeratin MNF116, HBME-1, and calretinin in the neoplastic cells, as well as focal positivity for epithelial membrane antigen positivity in a brush border-like pattern. All other markers were negative. We would like to stress that pathologists must be aware of the cytological and histological features of this rare variant of epithelioid malignant mesothelioma in order to avoid a misdiagnosis of a benign process or a metastatic malignancy.