RESUMO
Gastric hyperplastic polyps are usually solitary, their development is supposed to be associated with excessive proliferation of foveolar cells. It is essential to differentiate hyperplastic polyps from other sporadic polyps (adenomatous and fundic gland polyps) and lesions, included in familial polyposis syndromes. The frequency of adenocarcinoma in large gastric hyperplastic polyps (more than 1-2 cm in size) is about 2,1%. This article includes case report of gastric adenocarcinoma arised in large hyperplastic polyp in a 56-year-old patient. On histological examination a well-differentiated adenocarcinoma without invasion in the peduncle was identified. Immunohistochemically cells of adenocarcinoma showed elevated expression of claudin-3, CDX2, p53 and Ki67 compared to hyperplastic glands and dysplastic areas of the polyp. Also focal expression of MUC2 was revealed in adenocarcinoma. Expression of MUC5AC, CD44 and cyclin D1 was less prominent in cancer areas compared to hyperplastic and dysplastic glands. Levels of expression of claudin-1, claudin-4 and ß-catenin were equal in adenocarcinoma and hyperplastic structures. Control endoscopic examination with following morphologic examination was performed three months after surgical operation. No signs of tumor growth were identified.
Assuntos
Adenocarcinoma/patologia , Pólipos/patologia , Neoplasias Gástricas/patologia , Adenocarcinoma/complicações , Adenocarcinoma/genética , Adenocarcinoma/cirurgia , Fator de Transcrição CDX2/genética , Proliferação de Células/genética , Claudina-3/genética , Regulação Neoplásica da Expressão Gênica/genética , Humanos , Antígeno Ki-67/genética , Pessoa de Meia-Idade , Mucina-5AC/genética , Mucina-2/genética , Pólipos/complicações , Pólipos/genética , Pólipos/cirurgia , Neoplasias Gástricas/complicações , Neoplasias Gástricas/genética , Neoplasias Gástricas/cirurgia , Proteína Supressora de Tumor p53/genéticaRESUMO
Neck muscles play important role in body schema perception, pose and motor control. The mechanical neck muscles stimulation can influence these processes. On present investigation the kinesiology tape (KT) application was used as a local mechanical stimulation for M. sternocleidomastoideus. The results confirmed the influence of the KT application on the body schema perception. Moreover, the influence effect was lateralized in dependence on the side of the KT application. In most of the subjects the KT left application diminished the reaction time in the body schema mental rotation task. The right the KT application has not shown this effect. The possible causes of the KT application lateralized effect can be the proprioceptive asymmetry in neck muscles or the hemispheric functional asymmetry of the body schema perception process. The results may be useful for understanding the neurological nature of asymmetric body schema perception impairments as well as for the development of sport training methods.
Assuntos
Músculos do Pescoço/fisiologia , Percepção/fisiologia , Equilíbrio Postural/fisiologia , Adulto , Humanos , MasculinoRESUMO
To evaluate functional status of rat hindleg lymphatic drainage in dynamic experiments, Wistar rats were divided into three groups: control, experimental and a group exposed to induced lymphostimulation. Central lymphostasis was provoked in experimental and lymphostimulation group. The latter group was also exposed to lymphotropic lymphostimulation. Functional status of the lymphatic drainage was assessed by the time of appearance of the marker (methylene blue) injected into the rat paw. The results indicate that lymphatic drainage and a carrier function of the lymph node were suppressed in the experimental group during the observation time. Lymphostimulation in the third group corrected the above disorders by experiment day 30. Thus, lymphostimulation can be an alternative method of management of the central lymphostasis syndrome in clinical practice.
