RESUMO
The aqueous extract of Abutilon indicum was tested for hepatoprotective activity against carbon tetrachloride- and paracetamol-induced hepatotoxicities in rats. A. indicum exhibited significant hepatoprotective activity by reducing carbon tetrachloride- and paracetamol-induced change in bio-chemical parameters that was evident by enzymatic examination. The plant extract may interfere with free-radical formation, which may conclude in hepatoprotective action. Acute toxicity studies revealed that the LD50 value is more than the dose of 4 g/kg body wt.
Assuntos
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle , Malvaceae , Fitoterapia , Extratos Vegetais/farmacologia , Substâncias Protetoras/farmacologia , Acetaminofen , Administração Oral , Alanina Transaminase/sangue , Animais , Aspartato Aminotransferases/sangue , Tetracloreto de Carbono , Doença Hepática Induzida por Substâncias e Drogas/enzimologia , Doença Hepática Induzida por Substâncias e Drogas/etiologia , Relação Dose-Resposta a Droga , Feminino , Masculino , Extratos Vegetais/administração & dosagem , Extratos Vegetais/uso terapêutico , Folhas de Planta , Substâncias Protetoras/administração & dosagem , Substâncias Protetoras/uso terapêutico , Ratos , Ratos WistarRESUMO
Chemistry and pharmacology of Gymnema sylvestre is reviewed relying on research papers and patent literature. Extracts of this plant are widely used in Australian, Japananese, Vietnamese and Indian folk medicine. Gymnema preparations have a profound action on the modulation of taste, particularly suppressing sweet taste sensations. It is used in the treatment of diabetes mellitus and in food additives against obesity and caries. Anti-allergic, antiviral, lipid lowering and other effects are also reported. From a technological point of view, muchefforts have been made to mask the biter taste of Gymnema preparations.
Assuntos
Gymnema sylvestre/química , Fitoterapia , Animais , Humanos , Patentes como Assunto , Saponinas/química , Papilas Gustativas/fisiologia , Triterpenos/químicaAssuntos
Acetaminofen/antagonistas & inibidores , Allium/química , Analgésicos não Narcóticos/antagonistas & inibidores , Tetracloreto de Carbono/antagonistas & inibidores , Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle , Plantas Medicinais/química , Acetaminofen/toxicidade , Analgésicos não Narcóticos/toxicidade , Animais , Tetracloreto de Carbono/toxicidade , Doença Hepática Induzida por Substâncias e Drogas/patologia , Fígado/patologia , Testes de Função Hepática , Masculino , Extratos Vegetais/farmacologia , Ratos , Ratos WistarRESUMO
The effects of the aqueous extract of the leaf of Euphrasia officinale on blood glucose levels in normal and alloxan-diabetic rats were investigated. The treatment of alloxan-induced diabetic rats brought down the raised glucose levels, while the extract was devoid of hypoglycemic effect in normal rats.
