RESUMO
The mechanisms of action of information-wave technologies on human beings are analyzed in detail and their use in pediatrics is substantiated. The approach using a now-frequency pulse electromagnetic field as an information factor is optimal due to the synchronization of an oscillatory process of a low-frequency pulse electromagnetic field and the rhythm of functioning of different systems of the body, which causes the bioresonance actions the function of an organ or a system.
Assuntos
Campos Eletromagnéticos , Pediatria/instrumentação , Pediatria/métodos , HumanosRESUMO
Latent sensitization is a risk factor of a clinically manifest atopic reaction. Investigation of a phenotypic composition of lymphocytes reveals function of the immune system in this condition. Indirect fluorescence assessed differential and activation lymphocyte antigens (CD4, CD3, CD8, CD16, CD20 and CD25, CD71, HLA-DR, CD95, CD23, CD54, respectively) in 15 patients with latent sensitization, 32 patients with atopic bronchial asthma and 22 healthy donors. The immune system demonstrated definite activation with involvement ofT- and B-links of the immune system. Lymphocyte activation in latent sensitization and bronchial asthma differs by high expression of CD95 apoptosis trigger receptor. Enhancement of Fas-mediated lymphocyte apoptosis may inhibit IgE synthesis and atopic pathology manifestation.
Assuntos
Asma/imunologia , Hipersensibilidade Tardia/imunologia , Ativação Linfocitária/imunologia , Linfócitos/imunologia , Adulto , Alérgenos/imunologia , Antígenos CD/sangue , Antígenos CD/imunologia , Asma/sangue , Estudos de Casos e Controles , Feminino , Humanos , Hipersensibilidade Tardia/sangue , Imunoglobulina E/sangue , Imunoglobulina E/imunologia , Masculino , Pessoa de Meia-Idade , Pólen/imunologia , Testes CutâneosRESUMO
Three groups of activation antigens (receptors) of human peripheral blood lymphocytes (CD23, CD54--functional activation antigens, CD25 and CD71--early activation antigens and HLA-DR and CD95--late activation antigens) were studied in patients with inflammatory diseases of different types. All kinds of inflammation are independent of etiological factors and are associated with immune system activation. Inflammation induced by tissue injury or invasion of nonspecific microorganisms leads to a rapid rise in the count of lymphocytes expressing early markers of activation. Inhibition of inflammation occurs with a significant rise in peripheral blood lymphocytes with receptor of activation apoptosis CD95 (Fas-antigen). High number of lymphocytes with early markers of activation in line with high number of blood CD95+ lymphocytes take place in allergic and autoimmune diseases for a long time. Abnormal regulation of activation processes in lymphocytes in allergic and autoimmune diseases consists in the absence of lymphocyte activation inhibition in spite of high expression of CD95.
Assuntos
Antígenos de Diferenciação de Linfócitos T/análise , Inflamação/imunologia , Ativação Linfocitária , Linfócitos/imunologia , Adolescente , Adulto , Feminino , Humanos , Sistema Imunitário/imunologia , Masculino , Pessoa de Meia-IdadeRESUMO
Systemic immunity was studied in patients with chronic generalized parodontitis. This group of patients had distinct changes in immunologic system: depression of T- and stimulation of B-cellular immunity without accumulation of plasma cells and initiation of effective humoral response. Increased peripheral blood number of lymphocytes expressing induction of apoptosis CD95 receptors and ligand for this receptor CD95L (Fas-L) can lead to intensification of lymphocyte apoptosis and may be the reason for T-cell deficit development. The results of the study confirm the important role of immune system disturbances in pathogenesis of chronic generalized parodontitis.
Assuntos
Apoptose , Linfócitos B/imunologia , Periodontite/imunologia , Linfócitos T/imunologia , Linfócitos B/citologia , Proteína Ligante Fas , Humanos , Imunidade , Ativação Linfocitária , Glicoproteínas de Membrana/análise , Linfócitos T/citologia , Receptor fas/análiseRESUMO
The extract of the Tibetan medicine Taban-Arshan corrects changes of the immune system in inflammatory diseases--rheumatoid arthritis and atopic bronchial asthma. An immunomodulating effect of the drug consists in its ability to suppress hyperactivation of lymphocytes by normalization of expression of basic activation antigens.
Assuntos
Antígenos CD/imunologia , Artrite Reumatoide/imunologia , Asma/imunologia , Fatores Imunológicos/farmacologia , Linfócitos/efeitos dos fármacos , Medicina Tradicional Tibetana , Extratos Vegetais/farmacologia , Adulto , Antígenos CD/biossíntese , Artrite Reumatoide/sangue , Asma/sangue , Linfócitos B/efeitos dos fármacos , Linfócitos B/imunologia , Linfócitos B/metabolismo , Humanos , Técnicas In Vitro , Células Matadoras Naturais/efeitos dos fármacos , Células Matadoras Naturais/imunologia , Células Matadoras Naturais/metabolismo , Ativação Linfocitária/efeitos dos fármacos , Contagem de Linfócitos , Linfócitos/imunologia , Linfócitos/metabolismo , Linfócitos T/efeitos dos fármacos , Linfócitos T/imunologia , Linfócitos T/metabolismoAssuntos
Doenças Transmissíveis/complicações , Síndromes de Imunodeficiência/etiologia , Inflamação/complicações , Anti-Infecciosos/efeitos adversos , Anti-Infecciosos/uso terapêutico , Doenças Transmissíveis/tratamento farmacológico , Doenças Transmissíveis/imunologia , Resistência Microbiana a Medicamentos , Humanos , Síndromes de Imunodeficiência/imunologia , Inflamação/tratamento farmacológico , Inflamação/imunologiaAssuntos
Hipersensibilidade/imunologia , Miocardite/imunologia , Células Apresentadoras de Antígenos/patologia , Linfócitos B/imunologia , Linfócitos B/patologia , Biomarcadores/sangue , Progressão da Doença , Humanos , Hipersensibilidade/sangue , Hipersensibilidade/complicações , Hipersensibilidade/microbiologia , Miocardite/sangue , Miocardite/complicações , Miocardite/microbiologia , Linfócitos T/imunologia , Linfócitos T/patologiaRESUMO
Examinations of 121 patients with rheumatoid arthritis (RA) included immunological testing for antinuclear antibodies (ANA), lymphocyte blastogenesis test, and leukocyte migration inhibition test and functional cardiological examinations (ECG and EchoCG). RA patients with positive ANA test (n = 43) more often developed immune disorders: the titer of rheumatoid factor was higher and antibodies to type I collagen were more often detected; this was paralleled by decreased cellular immunity and macrophage formation in spontaneous lymphocyte blastogenesis test. The same group more often had ECG and EchoCG deviations. A conclusion is made about a probable role of immune disorders in the development of cardiac disease.
Assuntos
Artrite Reumatoide/imunologia , Cardiopatias/imunologia , Doenças do Sistema Imunitário/diagnóstico , Adulto , Formação de Anticorpos , Feminino , Humanos , Imunidade Celular , Masculino , Pessoa de Meia-IdadeAssuntos
Apoptose/imunologia , Asma/terapia , Hipersensibilidade Imediata/terapia , Imunoterapia , Linfócitos/patologia , Antígenos CD/sangue , Antígenos CD/imunologia , Asma/sangue , Asma/complicações , Asma/imunologia , Antígenos HLA-DR/imunologia , Humanos , Hipersensibilidade Imediata/sangue , Hipersensibilidade Imediata/complicações , Hipersensibilidade Imediata/imunologia , Ativação Linfocitária/imunologia , Linfócitos/imunologia , Receptor fas/imunologiaRESUMO
Immunological investigations in patients with rheumatic diseases (rheumatoid arthritis, Reiter's disease, infectious endocarditis, rheumatic heart disease) evidence that the time of onset of different immunologic pathogenetic mechanisms was the same. Immunological rehabilitation was achieved by different therapeutic methods: drugs, plasmapheresis, hemosorption, electrophoresis, ultrasound. In experiments it was beta-1-trophoblastic glycoprotein.