Managing primary open-angle glaucoma in the setting of suboptimal surgical outcomes in the fellow eye.

A 62-year-old woman with mild myopia presented to her local optometrist for a routine examination and was found to have intraocular pressure (IOP) of 30 mm Hg in both eyes and cupped nerves. She had a family history of glaucoma in her father. She was started on latanoprost in both eyes and was referred for a glaucoma evaluation. On initial evaluation, her IOP was 25 mm Hg in the right eye and 26 mm Hg in the left eye. Central corneal thickness measured 592 µm in the right eye and 581 µm in the left eye. Her angles were open to gonioscopy without any peripheral anterior synechia. She had 1+ nuclear sclerosis with a corrected distance visual acuity (CDVA) of 20/25 in the right eye and 20/30- in the left eye and uncorrected near visual acuity of J1+ in each eye. Her nerves were 0.85 mm in the right eye and 0.75 mm in the left eye. Optical coherence tomography (OCT) showed retinal nerve fiber layer thinning and a dense superior arcuate scotoma into fixation in her right eye, and superior and inferior arcuate scotomas in her left eye (Figures 1 and 2JOURNAL/jcrs/04.03/02158034-202307000-00019/figure1/v/2023-06-26T195222Z/r/image-tiffJOURNAL/jcrs/04.03/02158034-202307000-00019/figure2/v/2023-06-26T195222Z/r/image-tiff, Supplemental Figures 1 and 2, available at http://links.lww.com/JRS/A882 and http://links.lww.com/JRS/A883). She was successively trialed on fixed combination brimonidine-timolol, dorzolamide, and netarsudil, in addition to her latanoprost, but her IOP remained in the mid- to upper 20s in both eyes. The addition of acetazolamide lowered the pressure to 19 mm Hg in both eyes, but she tolerated it poorly. Methazolamide was also attempted with similar side effects. We elected to perform left eye cataract surgery combined with 360-degree viscocanaloplasty and insertion of a Hydrus microstent (Alcon Laboratories, Inc.). Surgery was uncomplicated with IOP of 16 mm Hg on postoperative day 1 with no glaucoma medications. However, by postoperative week 3, IOP returned to 27 mm Hg, and despite restarting latanoprost-netarsudil and finishing her steroid taper, IOP remained at 27 mm Hg by postoperative week 6. Brimonidine-timolol was added back to her left eye regimen and at postoperative week 8, IOP had elevated to 45 mm Hg. Maximizing her therapy with the addition of topical dorzolamide and oral methazolamide brought her IOP back down to 30 mm Hg. At that point, the decision was made to proceed with trabeculectomy of the left eye. The trabeculectomy was uneventful. However, postoperative attempts to augment filtration were rendered less successful by extremely thick Tenon layer. At her most recent follow-up the pressure in the left eye was mid-teens with brimonidine-timolol and dorzolamide. Her right eye IOP is in the upper 20s on maximum topical therapy. Knowing her postoperative course in the left eye, how would you manage the right eye? In addition to currently available options, would you consider a supraciliary shunt such as the MINIject (iSTAR) if such a device were U.S. Food and Drug Administration (FDA)-approved?

Posterior Cervical Fusion of Occiput-T3 for Unstable Complex Odontoid Fracture in an 80-Year-Old Male With C2-Sacrum Synostosis From Ankylosing Spondylitis: A Case Report.

Ankylosing spondylitis (AS) is an autoimmune arthritic condition that presents with inflammation of the axial skeleton and oligoarthritis of the peripheral joints. While its pathophysiology is not fully understood, the condition can lead to kyphosis and spontaneous intervertebral synostosis of the spine. AS is managed through both non-operative and operative means, but fractures in patients with AS are more complicated in those with synostosis. We present a case of a patient who is a tribal elder and Salish language instructor, with kyphotic AS with synostosis of C2-sacrum, and mobility confined to occiput-C1 and C1-C2. The patient suffered a low-energy fall backward from bed and presented to the orthopedic clinic approximately a month after his injury complaining of torticollis and neck pain. He was diagnosed to have a dens fracture, a right C2 pars/facet fracture, and a right lateral mass fracture with C1-C2 stenosis and cervical myelopathy. After the failure of conservative management, the patient required a full occiput-T3 fusion due to the osteoporosis and fragile AS synostosis of the spine, to mitigate transitional zone stresses that can occur with a shorter fusion. The fusion was successful, and it minimized the pain, corrected the torticollis, and allowed the patient to resume his tribal roles.

Posterior Reversible Encephalopathy Syndrome with Postoperative Hematoma After C4-C6 Spinal Fusion: A Case Report.

CASE: A 71-year-old woman with a 2-year history of spondylosis and radiculopathy presented with progressively worsening cervical spine pain and neurological dysfunction for 2 years. The patient developed posterior reversible encephalopathy syndrome (PRES) after postoperative hematoma in the retroesophageal and retropharyngeal areas. This occurred status post anterior cervical diskectomy and fusion (ACDF) of C4-C6. One year postoperatively, the patient recovered with full ambulation, neurological improvement, and resolution of all PRES signs and symptoms. CONCLUSION: We present a case of a previously undescribed outcome of PRES as a complication of ACDF likely related to postoperative hypertension and fragile blood vessels.

ACDF and posterior spinal fusion revision for posterior nonunion with deformity, myelopathy, and osteoporosis in an 87-year-old: A case report and literature review.

INTRODUCTION: Cervical spondylotic myelopathy (CSM) is a spinal degenerative disorder that can ultimately lead to compression of the vertebral column with neurological sequelae. Although CSM is the most common spine pathology in the elderly American population, it remains a challenging disorder to treat among older patients. CASE PRESENTATION: We report an 86 year old female patient with CSM with a history of posterior cervical fusion attempt on C3-C6 that progressed to C3-C6 nonunion with loose instrumentation. The patient had severe osteoporosis. With these indications, the patient underwent a combined anterior-posterior decompression and fusion (CAPDF) consisting of anterior cervical discectomy and fusion (ACDF) of the C3-C5, corpectomy of C6 and C7 with off FDA label use of polymethyl methacrylate augmentation (PMMA) fixation of T1 screws anteriorly for C3-T1 plate fixation and second stage instrumented posterior spinal fusion (PSF) of C3-T3. The patient had a successful fusion and reduction of her cervical spine pain with preservation of her neurological status. DISCUSSION: We report this case of multi-stage combined anterior and posterior fusion as a corrective measure for pseudarthrosis of a prior posterior cervical spinal fusion attempt. CONCLUSION: In the event of posterior spinal fusion instrumentation failure in patients with severe osteoporosis, combined multi-stage anterior-posterior fusion is a viable corrective intervention in octogenarians. This case also illustrated the utility of using PMMA for anterior cervical plate and screw stabilization in osteoporotic bone. The authors are not aware of the prior use of PMMA for screw fixation augmentation in the anterior cervical spine.