RESUMO
The paper presents the results of investigations on the hygienic standardization of the levels of selenium hexafluoride (SeF6) in the air of a working area. It also analyzes the data on the effects of SeF6 inhalation on laboratory animals, by applying morphological, physiological, hematological, and biochemical studies. The studies have yielded the basic parameters of inhalation toxicity and established the threshold of the irritant action of the substance, developed and approved its maximally acceptable concentration (0.2 mg/m3, gas + vapors) and a procedure for photometric determination of SeF6 in the air of a working area.
Assuntos
Poluentes Ocupacionais do Ar/análise , Poluentes Ocupacionais do Ar/toxicidade , Fluoretos/análise , Fluoretos/toxicidade , Compostos de Selênio/análise , Compostos de Selênio/toxicidade , Animais , Cobaias , Humanos , Inalação , Concentração Máxima Permitida , Modelos Teóricos , Fotometria , Coelhos , Ratos , Fatores de TempoRESUMO
The experiments on white rats, mice, guinea pigs, rabbits studied inhalation toxicity of piroxicam. The substance having strong cumulation (Jcum = 0.5) and embryotoxic effects (Limap = 0.1 mg/cum) is assigned to a group of parenchymatous poisons. Toxicometry data (CL50 = 250 mg/cum, Limac = 50 mg/cum, Limch = 0.5 mg/cum) prove the first jeopardy grade of the substance. The recommended MAC for workplace is 0.05 mg/cum.
Assuntos
Poluentes Ocupacionais do Ar/toxicidade , Anti-Inflamatórios não Esteroides/toxicidade , Indústria Farmacêutica , Piroxicam/toxicidade , Animais , Cobaias , Concentração Máxima Permitida , Camundongos , Coelhos , RatosRESUMO
Albino noninbred rats were exposed to hexachlorophene (chronic inhalation of 0.1 CL50 for 12 months). The tumors detected occurred mostly in the lungs. Increased incidence of lung tumors as well as their histomorphologic pattern (not typical of spontaneous neoplasms of these animals) suggested carcinogenicity of hexachlorophene under the said conditions.