1.
Effect of nutritional indoles on activity of xenobiotic metabolism enzymes and T-2 toxicity in rats.
Bull Exp Biol Med
; 131(6): 544-7, 2001 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11586402
RESUMO
Experiments on Wistar rats showed that feeding a ration containing 0.1% concentrate of food indoles (indole-3-carbinole and ascorbigen) for 3 weeks increased activity of phases I and II xenobiotic metabolism enzymes in the liver and intestinal mucosa and weakened the toxic effects of trichothecene T-2 mycotoxin. Activity of the key enzymes of T-2 detoxification, microsomal carboxylesterase and UDP-glucuronosyl transferase, was 1.5-2-fold higher in rats receiving T-2 toxin against the background of indole-enriched diet compared to toxin-treated rats kept on standard ration.