[The conservative treatment of acute hematogenous osteomyelitis in children]. / Shchadiashchee lechenie ostrogo gematogennogo osteomielita u detei.

Radioisotopes were used to study the water spaces of the bone and bone marrow in 47 dogs with a created model of acute osteomyelitis. By the 3rd-5th day of experimental osteomyelitis sharp hyperhydration of the bone marrow and bone proper was revealed which was caused by a 2.5-2.8-fold increase of the volume of intercellular fluid in the zone of the affection, leading to circulatory disorders and necrosis. Dehydration of the tissues is accomplished by inflicting numerous percutaneous osteoperforations (NPO) with Kirschner's wire. The osteoperforations are made not at random but in a regular manner through both walls of the bone in two interperpendicular planes. Circulation in the zone of the affection is restored in this case and osteonecrosis in prevented. Conservative methods of treatment of acute hematogenous osteomyelitis were developed according to the stage of its development and were applied in 168 patients whose ages ranged from 20 days to 14 years; in 75% of patients who were admitted in the early stages of AHO the disease took and abrupt course. In patients with neglected forms of AHO three-fourfold infliction of NPO in the subacute stage produced a stimulating effect on reparative regeneration in the zones of osteonecrosis and the forming sequestra.

[The morphological changes and cytochemical profile of the leukocytes in regulatory disorders of glucocorticoid secretion in the postresuscitation period]. / Morfologicheskie izmeneniia i tsitokhimicheskii profil' leikotsitov pri narusheniiakh reguliatsii sekretsii gliukokortikoidov v postreanimatsionnom periode.

It was shown in experiments on dogs who experienced death from blood loss that regulation of glucocorticoid secretion changes in phases. The changes are characterized by its disturbance in the first 3 days and a tendency to restoration 7 days after return to life. Disorders of function of the hypothalamo-hypophyseal-adrenal system were attended by a change of the intensity of metabolic processes in the leukocytes which depended on the duration of the circulatory arrest. On the 7th day of the postresuscitation period "dexamethasone depression" caused morphological and cytochemical changes of the leukocytes, which resembled those in intact animals.

[Impairment of glutathione metabolism in the liver of resuscitated rats and its correction]. / Narushenie obmena gliutationa v pecheni reanimirovannykh krys i ego korrektsiia.

Elevated synthesis of glutathione in liver tissue of rats after resuscitation did not exclude its deficiency in the animals. Administration of exogenous glutathione before asphyxia decreased the rate of structural membrane lipids peroxidation as well as contributed to more effective function of energy generation systems.